Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kristina Beeler"'
Autor:
Domenico Mallardo, Mario Fordellone, Andrew White, Jakob Vowinckel, Michael Bailey, Francesca Sparano, Antonio Sorrentino, Mario Mallardo, Bianca Arianna Facchini, Rosaria De Filippi, Gerardo Ferrara, Vito Vanella, Kristina Beeler, Paolo Chiodini, Alessandra Cesano, Sarah Warren, Paolo A. Ascierto
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9345 (2024)
Resistance biomarkers are needed to identify patients with advanced melanoma obtaining a response to ICI treatment and developing resistance later. We searched a combination of molecular signatures of response to ICIs in patients with metastatic mela
Externí odkaz:
https://doaj.org/article/c2ee6e498f014e2b90466676f1a10833
Autor:
Ying Jin, Xiaoyu An, Binchen Mao, Ruilin Sun, Rajendra Kumari, Xiaobo Chen, Yongli Shan, Mingfa Zang, Ling Xu, Jan Muntel, Kristina Beeler, Roland Bruderer, Lukas Reiter, Sheng Guo, Demin Zhou, Qi-Xiang Li, Xuesong Ouyang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Cancers are immunologically heterogeneous. A range of immunotherapies target abnormal tumor immunity via different mechanisms of actions (MOAs), particularly various tumor-infiltrate leukocytes (TILs). We modeled loss of function (LOF) in fo
Externí odkaz:
https://doaj.org/article/f458fcf37994447d8b6641e56cd067f3
Autor:
Kristina Beeler, Kamil Sklodowski, Sebastian Mueller, Roland Bruderer, Marco Tognetti, Dominique Kamber, Lukas Reiter
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/cb902ec1ba384a3397c097b877e2eedd
Autor:
Emanuela Romano, Kristina Beeler, Kamil Sklodowski, Vito Dozio, Silvia Lopez-Lastra, Andrés Lanzós
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/9ecd144aa8f04c08b243d837f14715c7
Autor:
Ying Jin, Xiaoyu An, Binchen Mao, Ruilin Sun, Rajendra Kumari, Xiaobo Chen, Yongli Shan, Mingfa Zang, Ling Xu, Jan Muntel, Kristina Beeler, Roland Bruderer, Lukas Reiter, Sheng Guo, Demin Zhou, Qi-Xiang Li, Xuesong Ouyang
Publikováno v:
Scientific reports. 12(1)
Cancers are immunologically heterogeneous. A range of immunotherapies target abnormal tumor immunity via different mechanisms of actions (MOAs), particularly various tumor-infiltrate leukocytes (TILs). We modeled loss of function (LOF) in four common
Autor:
Adam Hendricks, Nigel Beaton, Alexey Chernobrovkin, Eric Miele, Ghaith Hamza, Piero Ricchiuto, Ronald Tomlinson, Tomas Friman, Cassandra Borenstein, Bernard Barlaam, Sudhir Hande, Chris De Savi, Rick Davies, Martin Main, Joakim Hellner, Kristina Beeler, Yuehan Feng, Roland Bruderer, Lukas Reiter, Daniel Martinez Molina, Maria Paola Castaldi
Publikováno v:
Cancer Research. 82:2924-2924
In an effort to map the selectivity and understand the mode of action of a CDK9 inhibitor (compound 1), we employed several orthogonal proteomics methods. Our results show a clear selectivity against the CDK family of kinases, with the highest specif
Autor:
Anna Juncker-Jensen, Nigel Beaton, Kristina Beeler, Tobias Treiber, Mitchell Levesque, Julia M. Gomez, Harry Nunns, Xin-Xing Tan, Jakob Vowinckel
Publikováno v:
Cancer Research. 82:1267-1267
Background: Remarkable clinical success with immune checkpoint inhibitor (ICI) therapy has been achieved in recent years for the treatment of melanoma. However, despite the clinical advances of ICI therapy no durable responses are observed in 40-60%
Autor:
Andrés Lanzós, Emanuela Romano, Vito Dozio, Silvia Lopez-Lastra, Kamil Sklodowski, Kristina Beeler
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Immune checkpoint inhibitors have improved clinical responses and overall survival for patients with non-small cell lung cancer (NSCLC). However, the response is not equal and known NSCLC biomarkers are not sufficient in predicting therapy
Autor:
Mariaelena Capone, Daniel Heinzmann, Antonio Sorrentino, Martin Soste, Madonna Gabriele, Domenico Mallardo, Kristina Beeler, Kamil Sklodowski, Jakob Vowinckel, Vito Vanella, Paolo A. Ascierto
Publikováno v:
Regular and young investigator award abstracts.
Background Immune checkpoint inhibitors (ICI) have greatly improved the treatment options for patients with metastatic melanoma. Yet, a large percentage of melanoma patients do not respond to ICIs, there is a need for biomarkers that can predict pati
Autor:
Sebastian Mueller, Kristina Beeler, Lukas Reiter, Dominique Kamber, Marco Tognetti, Kamil Sklodowski, Roland Bruderer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundMass spectrometry-based discovery proteomics has recently emerged as a high-throughput method for the proteomic profiling in biofluid samples from large clinical and population screening cohorts. Despite this progress, a significant fractio