Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kristina B.M. Still"'
Autor:
Govert W. Somsen, Sarah Kidwai, Julien Slagboom, Zhengjin Jiang, Bastiaan Eisses, Chunfang Xie, Kristina B.M. Still, Jeroen Kool, Nicholas R. Casewell, Yumei Zhao, Freek J. Vonk
Publikováno v:
Still, K B M, Slagboom, J, Kidwai, S, Xie, C, Zhao, Y, Eisses, B, Jiang, Z, Vonk, F J, Somsen, G W, Casewell, N R & Kool, J 2020, ' Development of high-throughput screening assays for profiling snake venom phospholipase A 2 activity after chromatographic fractionation ', Toxicon, vol. 184, pp. 28-38 . https://doi.org/10.1016/j.toxicon.2020.05.022
Toxicon, 184, 28-38. Elsevier Limited
Toxicon, 184, 28-38. Elsevier Limited
Many organisms, ranging from plants to mammals, contain phospholipase A2 enzymes (PLA2s), which catalyze the production of lysophospholipids and fatty acid proinflammatory mediators. PLA2s are also common constituents of animal venoms, including bees
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2cfc6e54b87cc0590c27333c4578e53
https://research.vu.nl/en/publications/ff8e2e0f-7f4e-46f9-84d0-925208592cdc
https://research.vu.nl/en/publications/ff8e2e0f-7f4e-46f9-84d0-925208592cdc
Publikováno v:
Otvos, R A, Still, K B M, Somsen, G W, Smit, A B & Kool, J 2019, ' Drug Discovery on Natural Products : From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays ', SLAS Discovery, vol. 24, no. 3, pp. 362-385 . https://doi.org/10.1177/2472555218822098
Slas Discovery
Slas Discovery
Natural extracts are complex mixtures that may be rich in useful bioactive compounds and therefore are attractive sources for new leads in drug discovery. This review describes drug discovery from natural products and in explaining this process puts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0405f8f76edea378c724c4f249655d27
https://doi.org/10.1177/2472555218822098
https://doi.org/10.1177/2472555218822098
Autor:
Freek J. Vonk, Arif Arrahman, Nicholas R. Casewell, Jeroen Kool, Mark C. Wilkinson, Kristina B.M. Still, Govert W. Somsen, Taline D. Kazandjian
Publikováno v:
Toxins, 13(5):302, 1-20. Multidisciplinary Digital Publishing Institute (MDPI)
Toxins, Vol 13, Iss 302, p 302 (2021)
Toxins
Volume 13
Issue 5
Kazandjian, T D, Arrahman, A, Still, K B M, Somsen, G W, Vonk, F J, Casewell, N R, Wilkinson, M C & Kool, J 2021, ' Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib ', Toxins, vol. 13, no. 5, 302, pp. 1-20 . https://doi.org/10.3390/toxins13050302
Toxins, Vol 13, Iss 302, p 302 (2021)
Toxins
Volume 13
Issue 5
Kazandjian, T D, Arrahman, A, Still, K B M, Somsen, G W, Vonk, F J, Casewell, N R, Wilkinson, M C & Kool, J 2021, ' Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib ', Toxins, vol. 13, no. 5, 302, pp. 1-20 . https://doi.org/10.3390/toxins13050302
Bites from elapid snakes typically result in neurotoxic symptoms in snakebite victims. Neurotoxins are, therefore, often the focus of research relating to understanding the pathogenesis of elapid bites. However, recent evidence suggests that some ela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780fc7d1ebd5ac06f310ba446cf3be32
https://research.vu.nl/en/publications/d1b5b65c-2a5f-46bd-a7d9-845dd5919a21
https://research.vu.nl/en/publications/d1b5b65c-2a5f-46bd-a7d9-845dd5919a21
Autor:
Julien Slagboom, Nicholas R. Casewell, Govert W. Somsen, Zhengjin Jiang, Freek J. Vonk, Yumei Zhao, Jeroen Kool, Laura-Oana Albulescu, Kristina B.M. Still, Chunfang Xie
Publikováno v:
Biomedicines
Volume 8
Issue 6
Biomedicines, Vol 8, Iss 165, p 165 (2020)
Xie, C, Albulescu, L O, Still, K B M, Slagboom, J, Zhao, Y, Jiang, Z, Somsen, G W, Vonk, F J, Casewell, N R & Kool, J 2020, ' Varespladib inhibits the phospholipase A 2 and coagulopathic activities of venom components from hemotoxic snakes ', Biomedicines, vol. 8, no. 6, 165, pp. 1-17 . https://doi.org/10.3390/biomedicines8060165
Biomedicines, 8(6):165, 1-17. MDPI AG
Volume 8
Issue 6
Biomedicines, Vol 8, Iss 165, p 165 (2020)
Xie, C, Albulescu, L O, Still, K B M, Slagboom, J, Zhao, Y, Jiang, Z, Somsen, G W, Vonk, F J, Casewell, N R & Kool, J 2020, ' Varespladib inhibits the phospholipase A 2 and coagulopathic activities of venom components from hemotoxic snakes ', Biomedicines, vol. 8, no. 6, 165, pp. 1-17 . https://doi.org/10.3390/biomedicines8060165
Biomedicines, 8(6):165, 1-17. MDPI AG
Phospholipase A2 (PLA2) enzymes are important toxins found in many snake venoms, and they can exhibit a variety of toxic activities including causing hemolysis and/or anticoagulation. In this study, the inhibiting effects of the small molecule PLA2 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f876f0f58598a5e95659ee4aa142fa52
Autor:
Nicholas R. Casewell, Kristina B.M. Still, Freek J. Vonk, Chunfang Xie, Jeroen Kool, Julien Slagboom, Kidwai S, Eisses B, Govert W. Somsen
Many organisms, ranging from plants to mammals, contain phospholipase A2enzymes (PLA2s), which catalyze the production of lysophospholipids and fatty acid proinflammatory mediators. PLA2s are also common constituents of animal venoms, including bees,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0487a3c719101ae6bce70a86164196
Autor:
Chunfang Xie, Ben Bruyneel, Jeroen Kool, Freek J. Vonk, Julien Slagboom, Laura-Oana Albulescu, Govert W. Somsen, Nicholas R. Casewell, Kristina B.M. Still
Publikováno v:
Toxins
Xie, C, Slagboom, J, Albulescu, L O, Bruyneel, B, Still, K B M, Vonk, F J, Somsen, G W, Casewell, N R & Kool, J 2020, ' Antivenom neutralization of coagulopathic snake venom toxins assessed by bioactivity profiling using nanofractionation analytics ', Toxins, vol. 12, no. 1, 53, pp. 1-16 . https://doi.org/10.3390/toxins12010053
Volume 12
Issue 1
Toxins, 12(1):53, 1-16. Multidisciplinary Digital Publishing Institute (MDPI)
Toxins, Vol 12, Iss 1, p 53 (2020)
Xie, C, Slagboom, J, Albulescu, L O, Bruyneel, B, Still, K B M, Vonk, F J, Somsen, G W, Casewell, N R & Kool, J 2020, ' Antivenom neutralization of coagulopathic snake venom toxins assessed by bioactivity profiling using nanofractionation analytics ', Toxins, vol. 12, no. 1, 53, pp. 1-16 . https://doi.org/10.3390/toxins12010053
Volume 12
Issue 1
Toxins, 12(1):53, 1-16. Multidisciplinary Digital Publishing Institute (MDPI)
Toxins, Vol 12, Iss 1, p 53 (2020)
Venomous snakebite is one of the world&rsquo
s most lethal neglected tropical diseases. Animal-derived antivenoms are the only standardized specific therapies currently available for treating snakebite envenoming, but due to venom variation, oft
s most lethal neglected tropical diseases. Animal-derived antivenoms are the only standardized specific therapies currently available for treating snakebite envenoming, but due to venom variation, oft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0d6cfe7f303847d13641f1a380cc13
https://pubmed.ncbi.nlm.nih.gov/31963329
https://pubmed.ncbi.nlm.nih.gov/31963329
Autor:
Dick J. van Iperen, Matthijs Luger, Barbara M. Zietek, Ben Bruyneel, Tinco J. F. Brouwer, Freek Ariese, Rob J. Limburg, Kristina B.M. Still, Nicholas R. Casewell, Kevin Jaschusch, Govert W. Somsen, Jeroen Kool, Joost C. Rosier
Publikováno v:
Analytical Chemistry
Zietek, B M, Still, K B M, Jaschusch, K, Bruyneel, B, Ariese, F, Brouwer, T J F, Luger, M, Limburg, R J, Rosier, J C, V Iperen, D J, Casewell, N R, Somsen, G W & Kool, J 2019, ' Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation ', Analytical Chemistry, vol. 91, no. 16, pp. 10458-10466 . https://doi.org/10.1021/acs.analchem.9b01261
Analytical Chemistry, 91(16), 10458-10466. American Chemical Society
Zietek, B M, Still, K B M, Jaschusch, K, Bruyneel, B, Ariese, F, Brouwer, T J F, Luger, M, Limburg, R J, Rosier, J C, V Iperen, D J, Casewell, N R, Somsen, G W & Kool, J 2019, ' Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation ', Analytical Chemistry, vol. 91, no. 16, pp. 10458-10466 . https://doi.org/10.1021/acs.analchem.9b01261
Analytical Chemistry, 91(16), 10458-10466. American Chemical Society
High-throughput screening platforms for the identification of bioactive compounds in mixtures have become important tools in the drug discovery process. Miniaturization of such screening systems may overcome problems associated with small sample volu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95cff70f2d9aac50c88a575c2e68cdbb
https://archive.lstmed.ac.uk/11389/1/acs.analchem.pdf
https://archive.lstmed.ac.uk/11389/1/acs.analchem.pdf
Autor:
Kristina B.M. Still, Nicholas R. Casewell, Jeroen Kool, Randjana R.S.S. Nandlal, Govert W. Somsen, Julien Slagboom
Publikováno v:
Toxins, Vol 9, Iss 12, p 382 (2017)
Still, K B M, Nandlal, R S S, Slagboom, J, Somsen, G W, Casewell, N R & Kool, J 2017, ' Multipurpose HTS Coagulation Analysis: Assay Development and Assessment of Coagulopathic Snake Venoms ', Toxins, vol. 9, no. 12, 382 . https://doi.org/10.3390/toxins9120382
Toxins, 9(12):382. Multidisciplinary Digital Publishing Institute (MDPI)
Still, K B M, Nandlal, R S S, Slagboom, J, Somsen, G W, Casewell, N R & Kool, J 2017, ' Multipurpose HTS Coagulation Analysis: Assay Development and Assessment of Coagulopathic Snake Venoms ', Toxins, vol. 9, no. 12, 382 . https://doi.org/10.3390/toxins9120382
Toxins, 9(12):382. Multidisciplinary Digital Publishing Institute (MDPI)
Coagulation assays currently employed are often low throughput, require specialized equipment and/or require large blood/plasma samples. This study describes the development, optimization and early application of a generic low-volume and high-through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0dac45da33fe8cd0910124eab9d4d0b
https://www.mdpi.com/2072-6651/9/12/382
https://www.mdpi.com/2072-6651/9/12/382