Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Kristina Althoff"'
Autor:
Phyllis F. Cheung, JiaJin Yang, Rui Fang, Arianna Borgers, Kirsten Krengel, Anne Stoffel, Kristina Althoff, Chi Wai Yip, Elaine H. L. Siu, Linda W. C. Ng, Karl S. Lang, Lamin B. Cham, Daniel R. Engel, Camille Soun, Igor Cima, Björn Scheffler, Jana K. Striefler, Marianne Sinn, Marcus Bahra, Uwe Pelzer, Helmut Oettle, Peter Markus, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Konstantinos Savvatakis, Sven-Thorsten Liffers, Smiths S. Lueong, Christian Neander, Anna Bazarna, Xin Zhang, Annette Paschen, Howard C. Crawford, Anthony W. H. Chan, Siu Tim Cheung, Jens T. Siveke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation o
Externí odkaz:
https://doaj.org/article/c9aa189db2194c2eba13f30f461a6fdd
Autor:
Lena Quambusch, Laura Depta, Ina Landel, Melissa Lubeck, Tonia Kirschner, Jonas Nabert, Niklas Uhlenbrock, Jörn Weisner, Michael Kostka, Laura M. Levy, Carsten Schultz-Fademrecht, Franziska Glanemann, Kristina Althoff, Matthias P. Müller, Jens T. Siveke, Daniel Rauh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Elucidating specific effects of protein kinase Akt isoforms remains challenging. Here, the authors establish an Akt isoform-dependent cellular model system and use it, together with X-ray crystallography and structure-based ligand design, to develop
Externí odkaz:
https://doaj.org/article/e9d5b9b56b6e4d8f9a3489c70c876e8e
Autor:
Michael Hölzel, Johanna A Seier, Julia Reinhardt, Kritika Saraf, Susanna S Ng, Julian P Layer, Dillon Corvino, Kristina Althoff, Frank A Giordano, Alexander Schramm, Matthias Fischer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Background Amplification of the MYCN oncogene is a molecular hallmark of aggressive neuroblastoma (NB), a childhood cancer of the sympathetic nervous system. There is evidence that MYCN promotes a non-inflamed and T-cell infiltration-poor (‘cold’
Externí odkaz:
https://doaj.org/article/75f445efff124427aef7051679196de1
Autor:
Julian P. Layer, Marie T. Kronmüller, Thomas Quast, Debby van den Boorn-Konijnenberg, Maike Effern, Daniel Hinze, Kristina Althoff, Alexander Schramm, Frank Westermann, Martin Peifer, Gunther Hartmann, Thomas Tüting, Waldemar Kolanus, Matthias Fischer, Johannes Schulte, Michael Hölzel
Publikováno v:
OncoImmunology, Vol 6, Iss 6 (2017)
Immune checkpoint inhibitors have significantly improved the treatment of several cancers. T-cell infiltration and the number of neoantigens caused by tumor-specific mutations are correlated to favorable responses in cancers with a high mutation load
Externí odkaz:
https://doaj.org/article/555e23614fd84c37a22250949f85dd1a
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
Mechanisms of reduced cell viability induced by OTX015 are cell line dependent. OTX015 reduces cell proliferation over time and induces cell cycle changes as well as apoptosis. (a) Representative photomicrographs of neuroblastoma cell lines treated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6c21717502a0e406b5de6278290afd
https://doi.org/10.1158/1078-0432.22458717
https://doi.org/10.1158/1078-0432.22458717
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
All H3K27Ac peaks called in non-promoter regions in IMR5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0bdb3202921740e4a27fb7232c3f5c
https://doi.org/10.1158/1078-0432.22458729.v1
https://doi.org/10.1158/1078-0432.22458729.v1
Autor:
Jens T. Siveke, Mathias F. Heikenwalder, Marija Trajkovic-Arsic, Alexandr V. Bazhin, Dieter Saur, David G Kirsch, Everett J. Moding, Chang-Lung Lee, Kristina Althoff, Sven-Thorsten Liffers, Konstantinos Savvatakis, Anna Bazarna, Christian Neander, Florian Neff, Phyllis F. Cheung
Nanostring PanCancer Immune profiling analysis and validation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d68fbb00b93f6234955326ef71dc93
https://doi.org/10.1158/0008-5472.22425645
https://doi.org/10.1158/0008-5472.22425645
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
OTX015 has no significant effect on non-malignant human fibroblasts. (a) Representative pictures of human fibroblasts treated for 72 h with 500 nM OTX015 or DMSO control. Scale bar=100 µm. (b) Growth of fibroblasts treated with 500 nM OTX015 (black)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079d20d24933361e5347a563449a502c
https://doi.org/10.1158/1078-0432.22458723
https://doi.org/10.1158/1078-0432.22458723
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
GSEA of gene sets describing general cellular processes after treatment with OTX015 and/or JQ1(GSEA, Broad institute)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342c4514be8e32a13a17e6c8666271cc
https://doi.org/10.1158/1078-0432.22458735.v1
https://doi.org/10.1158/1078-0432.22458735.v1
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
BET inhibition preferentially disrupts expression of genes associated with super-enhancers. (a) ChIP-seq profiles for H3K27Ac binding at representative super-enhancer-associated gene loci, including MYCN, NCOR2, BCOR and GLI2, in MYCN-amplified IMR-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde9e59bc7ca07c5c3ec4d2b98e90f35
https://doi.org/10.1158/1078-0432.22458705.v1
https://doi.org/10.1158/1078-0432.22458705.v1