Diagnostic Delay of Spinal Tuberculosis Causing Medullary Compression

Autor: Krestine Corydon, Matilde Bjørn Ørum, Kristoffer Backman Nøhr, Kristina Öbrink-Hansen

Publikováno v: Case Reports in Infectious Diseases, Vol 2024 (2024)

We present a case of a Philippine woman in her late twenties, diagnosed with spinal tuberculosis after surgical intervention due to medullary compression. The diagnosis was preceded by four months of unexplained back pain. Differential diagnoses incl

Externí odkaz: https://doaj.org/article/d7dc8e2d352b4564b7a290970dd43af6

Steady-State Piperacillin Concentrations in the Proximity of an Orthopedic Implant: A Microdialysis Porcine Study

Autor: Johanne Gade Lilleøre, Andrea René Jørgensen, Martin Bruun Knudsen, Pelle Hanberg, Kristina Öbrink-Hansen, Sara Kousgaard Tøstesen, Kjeld Søballe, Maiken Stilling, Mats Bue

Publikováno v: Antibiotics, Vol 12, Iss 3, p 615 (2023)

Implant-associated osteomyelitis is one of the most feared complications following orthopedic surgery. Although the risk is low, sufficient antibiotic protection of the implant surface is important. The aim of this study was to assess steady-state pi

Externí odkaz: https://doaj.org/article/3ee07e0a6ad747d491d9be2007ce09de

Intermittent Short-Term Infusion vs. Continuous Infusion of Piperacillin: Steady State Concentrations in Porcine Cervical Spine Tissue Evaluated by Microdialysis

Autor: Elisabeth Krogsgaard Petersen, Pelle Hanberg, Martin Knudsen, Sara Kousgaard Tøstesen, Andrea René Jørgensen, Kristina Öbrink-Hansen, Kjeld Søballe, Maiken Stilling, Mats Bue

Publikováno v: Antibiotics, Vol 11, Iss 7, p 910 (2022)

Background: Piperacillin is a central drug in the treatment of Pseudomonas aeruginosa spondylodiscitis. Intermittent short-term infusion (STI) remains standard treatment in most centres, although the application of continuous infusion (CI) has shown

Externí odkaz: https://doaj.org/article/1c61e5aae15040e0855b8a04a86c62b3

Flucloxacillin bone and soft tissue concentrations assessed by microdialysis in pigs after intravenous and oral administration

Autor: Maja B. Thomassen, Mats Bue, Maiken Stilling, Mathias Alrø Fichtner Bendtsen, Josefine Slater, Jakob Hansen, Kristina Öbrink-Hansen, Kjeld Søballe, Pelle Hanberg

Publikováno v: Bone & Joint Research, Vol 10, Iss 1, Pp 60-67 (2021)
Bone & Joint Research
Bendtsen, M A F, Bue, M, Hanberg, P E, Slater, J, Thomassen, M, Hansen, J, Søballe, K, Öbrink-Hansen, K M & Stilling, M 2021, ' Flucloxacillin bone and soft tissue concentrations assessed by microdialysis in pigs after intravenous and oral administration ', Bone and Joint Research, vol. 10, no. 1, pp. 60-67 . https://doi.org/10.1302/2046-3758.101.BJR-2020-0250.R1

Aims Flucloxacillin is commonly administered intravenously for perioperative antimicrobial prophylaxis, while oral administration is typical for prophylaxis following smaller traumatic wounds. We assessed the time, for which the free flucloxacillin c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa60d726d845a5a363f81a1aea4eced
https://doi.org/10.1302/2046-3758.101.bjr-2020-0250.r1

Simultaneous Retrodialysis by Drug for Cefuroxime Using Meropenem as an Internal Standard—A Microdialysis Validation Study

Autor: Jesper Kabel, Kristina Öbrink-Hansen, Mats Bue, Maiken Stilling, Mikkel Tøttrup, Maja B. Thomassen, Kjeld Søballe, Pelle Hanberg

Publikováno v: Hanberg, P, Bue, M, Öbrink-Hansen, K, Kabel, J, Thomassen, M, Tøttrup, M, Søballe, K & Stilling, M 2020, ' Simultaneous retrodialysis by drug for cefuroxime using meropenem as an internal standard : A microdialysis validation study ', Journal of Pharmaceutical Sciences, vol. 109, no. 3, pp. 1373-1379 . https://doi.org/10.1016/j.xphs.2019.11.014

Microdialysis is a valuable pharmacokinetic tool for obtaining samples of drug concentrations from tissues of interest. When an absolute tissue concentration is needed, a calibration of the microdialysis catheter is required. The use of an internal s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3422c44fdf006c9591ba2bf470e8810
https://doi.org/10.1016/j.xphs.2019.11.014