Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kristina, Schachtrup"'
Autor:
M. Charlotte Hemmer, Michael Wierer, Kristina Schachtrup, Michael Downes, Norbert Hübner, Ronald M. Evans, N. Henriette Uhlenhaut
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver,
Externí odkaz:
https://doaj.org/article/c66a0d65c60642e39dc4efc1ae62484e
Autor:
Astrid Pechmann, Kirsten König, Günther Bernert, Kristina Schachtrup, Ulrike Schara, David Schorling, Inge Schwersenz, Sabine Stein, Adrian Tassoni, Sibylle Vogt, Maggie C. Walter, Hanns Lochmüller, Janbernd Kirschner
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 14, Iss 1, Pp 1-6 (2019)
Abstract Background Survival and quality of life for patients affected by spinal muscular atrophy (SMA) are thought to have improved over the last decade due to changes in care. In addition, targeted treatments for SMA have been developed based on a
Externí odkaz:
https://doaj.org/article/a83b67a28e984288b50f76b05e169552
Autor:
Thibault Bouderlique, Lucia Peña-Pérez, Shabnam Kharazi, Miriam Hils, Xiaoze Li, Aleksandra Krstic, Ayla De Paepe, Christian Schachtrup, Charlotte Gustafsson, Dan Holmberg, Kristina Schachtrup, Robert Månsson
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopo
Externí odkaz:
https://doaj.org/article/1af298c86d8b48858c69130b64b272cd
Autor:
Alexandra Müller, Sehar Afreen, Julia Miriam Weiss, Eva-Maria Demmerath, Kristina Schachtrup, Jonas S. Jutzi, Sheila Bohler, Mirjam Kunze, Miriam Erlacher
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 1, Pp 1-15 (2020)
Cell Death and Disease, Vol 11, Iss 1, Pp 1-15 (2020)
The anti-apoptotic BCL-2 proteins (BCL-2, BCL-XL, MCL-1, A1, BCL-W) counteract apoptotic signals emerging during development and under stress conditions, and are thus essential for the survival of every cell. While the “BCL-2 addiction” of differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e634e75871217cbb82e0e6aa060d37b2
https://doi.org/10.1038/s41419-019-2203-z
https://doi.org/10.1038/s41419-019-2203-z
Autor:
Irina Zaidman, Jerry Stein, Klaus Warnatz, Amir A. Kuperman, O. Sascha Yousefi, Mikael Sigvardsson, Polina Stepensky, Wolfgang W. A. Schamel, Dov Hershkovitz, Orly Elpeleg, Avraham Shaag, Baerbel Keller, Kristina Schachtrup, Susanne Unger
Publikováno v:
Journal of Experimental Medicine. 213:1185-1199
The adapter protein linker for activation of T cells (LAT) is a critical signaling hub connecting T cell antigen receptor triggering to downstream T cell responses. In this study, we describe the first kindred with defective LAT signaling caused by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8947161654dd031ee2303be897cc0c
https://doi.org/10.1084/jem.20151110
https://doi.org/10.1084/jem.20151110
Autor:
Astrid, Pechmann, Kirsten, König, Günther, Bernert, Kristina, Schachtrup, Ulrike, Schara, David, Schorling, Inge, Schwersenz, Sabine, Stein, Adrian, Tassoni, Sibylle, Vogt, Maggie C, Walter, Hanns, Lochmüller, Janbernd, Kirschner
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 14, Iss 1, Pp 1-6 (2019)
Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases
Background Survival and quality of life for patients affected by spinal muscular atrophy (SMA) are thought to have improved over the last decade due to changes in care. In addition, targeted treatments for SMA have been developed based on a better un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3c396d53d7eae737a2f42ae0c7dccc47
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85060249960
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85060249960
Autor:
Ronald M. Evans, M. Charlotte Hemmer, Michael Downes, N. Henriette Uhlenhaut, Norbert Hubner, Kristina Schachtrup, Michael Wierer
Publikováno v:
Nat. Commun. 10:306 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Glucocorticoids (GCs) are effective drugs, but their clinical use is compromised by severe side effects including hyperglycemia, hyperlipidemia and obesity. They bind to the Glucocorticoid Receptor (GR), which acts as a transcription factor. The acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa61ab5af2dc7c32d3dedc5a2c797c89
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55255
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55255
Autor:
Lucía Peña-Pérez, Xiaoze Li, Robert Månsson, Miriam Hils, Aleksandra Krstic, Ayla De Paepe, Thibault Bouderlique, Christian Schachtrup, Charlotte Gustafsson, Shabnam Kharazi, Kristina Schachtrup, Dan Holmberg
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
The apparition of adaptive immunity inGnathostomatacorrelates with the expansion of the E-protein family to encompass E2-2, HEB and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a87b7dc48c4f850c33f0e325d5820ac
Autor:
Sebastian J. Arnold, Laure Garnier, Katharina S. Rauch, Kristina Schachtrup, Sophie Laffont, Maria Brack, Ana Izcue, Jean-Charles Guéry, Ekaterina Lupar
Publikováno v:
The Journal of Immunology. 195:4742-4752
CD4+ T cells polarize into effector Th subsets characterized by signature transcription factors and cytokines. Although T-bet drives Th1 responses and represses the alternative Th2, Th17, and Foxp3+ regulatory T cell fates, the role of the T-bet–re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82aca748493f111e0ae800e9b35ff4c0
https://doi.org/10.4049/jimmunol.1501159
https://doi.org/10.4049/jimmunol.1501159
Autor:
Dietmar Pfeifer, Leandra Plappert, Miriam Hils, Könül Mammadzada, Christian Schachtrup, Kristina Schachtrup, Katharina S. Rauch, Christian Bohrer, Matthias Kirsch, Verónica I. Dumit, Jörn Dengjel, Sebastian Schildge, Lauriane Pous, Sabrina Pfurr
Publikováno v:
The EMBO Journal. 34:2804-2819
Adult neural stem/precursor cells (NSPCs) of the subventricular zone (SVZ) are an endogenous source for neuronal replacement in CNS disease. However, adult neurogenesis is compromised after brain injury in favor of a glial cell fate, which is mainly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936a66422be14c8f1544d0ed44e2635b
https://doi.org/10.15252/embj.201591118
https://doi.org/10.15252/embj.201591118