Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses

Autor: Niki Dimou, Andre E. Kim, Orlagh Flanagan, Neil Murphy, Virginia Diez-Obrero, Anna Shcherbina, Elom K Aglago, Emmanouil Bouras, Peter T Campbell, Graham Casey, Steven Gallinger, Stephen B Gruber, Mark A Jenkins, Yi Lin, Victor Moreno, Edward Ruiz-Narvaez, Mariana C Stern, Yu Tian, Kostas K Tsilidis, Volker Arndt, Elizabeth L Barry, James W Baurley, Sonja I Berndt, Stéphane Bézieau, Stephanie A Bien, D Timothy Bishop, Hermann Brenner, Arif Budiarto, Robert Carreras-Torres, Tjeng Wawan Cenggoro, Andrew T Chan, Jenny Chang-Claude, Stephen J Chanock, Xuechen Chen, David V Conti, Christopher H Dampier, Matthew Devall, David Drew, Jane C Figueiredo, Graham G Giles, Andrea Gsur, Tabitha A Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R Huyghe, Kristina Jordahl, Eric Kawaguchi, Temitope O Keku, Susanna C Larsson, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Bharuno Mahesworo, John Morrison, Polly A Newcomb, Christina C Newton, Mireia Obon-Santacana, Jennifer Ose, Rish K Pai, Julie R Palmer, Nick Papadimitrou, Bens Pardamean, Anita R Peoples, Paul D P Pharoah, Elizabeth A Platz, John D Potter, Gad Rennert, Peter C Scacheri, Robert E Schoen, Yu-Ru Su, Catherine M Tangen, Stephen N Thibodeau, Duncan C Thomas, Cornelia Ulrich, Caroline Y Um, Franzel JB van Duijnhoven, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Emily White, Alicja Wolk, Michael O Woods, Conghui Qu, Anshul Kundaje, Li Hsu, W. James Gauderman, Marc J Gunter, Ulrike Peters

Diabetes is an established risk factor for colorectal cancer; however, the mechanisms underlying this relationship are not fully understood and the role of genetic variation is unclear. We used data from 3 genetic consortia (CCFR, CORECT, GECCO; 31,3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c51d5cff8c748fbf24b3aca35f3e7ffb
https://doi.org/10.1101/2022.10.16.22280490

Epigenome-wide meta-analysis of BMI in nine cohorts: examining the utility of epigenetic BMI in predicting metabolic health

Autor: Whitney L. Do, Dianjianyi Sun, Karlijn Meeks, Pierre-Antoine Dugue, Ellen Demerath, Weihua Guan, Shengxu Li, Wei Chen, Roger Milne, Abedowale Adeyemo, Charles Agyemang, Rami Nassir, JoAnn Manson, Aladdin H Shadyab, Lifang Hou, Steve Horvath, Themistocles L. Assimes, Parveen Bhatti, Kristina Jordahl, Andrea Baccarelli, Alicia Smith, Lisa R. Staimez, Aryeh Stein, Eric A. Whitsel, K.M. Venkat Narayan, Karen Conneely

This study sought to examine the association between DNA methylation and body mass index (BMI) and the potential utility of these cytosine-phosphate-guanine (CpG) sites in predicting metabolic health. We pooled summary statistics from six trans-ethni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2edd1c67de30f76d0611b46614a97cc1
https://doi.org/10.1101/2022.07.26.498234

Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women

Autor: Purva, Jain, Alexandra M, Binder, Brian, Chen, Humberto, Parada, Linda C, Gallo, John, Alcaraz, Steve, Horvath, Parveen, Bhatti, Eric A, Whitsel, Kristina, Jordahl, Andrea A, Baccarelli, Lifang, Hou, James D, Stewart, Yun, Li, Jamie N, Justice, Andrea Z, LaCroix

Publikováno v: JAMA Network Open. 5:e2223285

Accelerated biological aging is associated with decreased physical capability and cognitive functioning, which are associated with increased risk of morbidity and mortality.We investigated associations between epigenetic age acceleration (EAA), a bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365c6b9bddc32538de2ff82e50f13593
https://doi.org/10.1001/jamanetworkopen.2022.23285