Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kristin T Chun"'
Autor:
Kristin T Chun, Binghui Li, Erika Dobrota, Courtney Tate, Jeong-Heon Lee, Shehnaz Khan, Laura Haneline, Harm HogenEsch, David G Skalnik
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113745 (2014)
CXXC finger protein 1 (Cfp1), encoded by the Cxxc1 gene, binds to DNA sequences containing an unmethylated CpG dinucleotide and is an epigenetic regulator of both cytosine and histone methylation. Cxxc1-null mouse embryos fail to gastrulate, and Cxxc
Externí odkaz:
https://doaj.org/article/bc19738d5e6d4473b7bac445f44b5df8
Autor:
Angela Bruzzaniti, Melissa A. Kacena, Ying Hua Cheng, Jung Min Hong, Christine M. Eischen, Robyn K. Fuchs, Lindsey D. Mayo, Daniel S. Perrien, R. Adam Hooker, David J. Olivos, Kristin T. Chun
Publikováno v:
Journal of Cellular Biochemistry. 119:8830-8840
Mouse double minute 2 (Mdm2) is a multifaceted oncoprotein that is highly regulated with distinct domains capable of cellular transformation. Loss of Mdm2 is embryonically lethal, making it difficult to study in a mouse model without additional genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4de678b53f2b0b09ccf23cb987d2860
https://doi.org/10.1002/jcb.27133
https://doi.org/10.1002/jcb.27133
Publikováno v:
Blood. 110:2704-2707
Several hematopoietic stem-cell (HSC) regulators are controlled by ubiquitin-mediated proteolysis, so the ubiquitin pathway might modulate HSC function. However, this hypothesis has not been formally tested. Cul4A encodes a core subunit of one ubiqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac4d729b4fb2042cd321ddcb4799377
https://doi.org/10.1182/blood-2006-12-064154
https://doi.org/10.1182/blood-2006-12-064154
Publikováno v:
Blood. 107:4291-4299
As erythroid progenitors differentiate into precursors and finally mature red blood cells, lineage-specific genes are induced, and proliferation declines until cell cycle exit. Cul4A encodes a core subunit of a ubiquitin ligase that targets proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690d4d719aafd5fdb669f152b3178fbb
https://doi.org/10.1182/blood-2005-08-3349
https://doi.org/10.1182/blood-2005-08-3349
Publikováno v:
Molecular and Cellular Biology. 22:4997-5005
Ubiquitin-mediated degradation targets cell cycle regulators for proteolysis. Much of the ubiquitin pathway's substrate specificity is conferred by E3 ubiquitin ligases, and cullins are core components of some E3s. CUL-4A encodes one of six mammalian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c2e544aa2ac847787d0939ce2e70dd
https://doi.org/10.1128/mcb.22.14.4997-5005.2002
https://doi.org/10.1128/mcb.22.14.4997-5005.2002
Publikováno v:
Journal of Biological Chemistry. 273:31337-31344
Control of glycogen synthase activity by protein phosphorylation is important for regulating the synthesis of glycogen. In this report, we describe a regulatory linkage between the ability of yeast cells to respire and activation of glycogen synthase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec5a9251d15d229467dde63cd3068d0
https://doi.org/10.1074/jbc.273.47.31337
https://doi.org/10.1074/jbc.273.47.31337
Publikováno v:
Yeast. 13:233-240
Although the entire DNA sequence of the yeast genome has been determined, the functions of nearly a third of the identified genes are unknown. Recently, we described a collection of mutants, each with a transposon-tagged disruption in an essential ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b160dfb35f8516a4df89b0fd3ddfa78
https://doi.org/10.1002/(sici)1097-0061(19970315)13:3<233::aid-yea88>3.0.co
https://doi.org/10.1002/(sici)1097-0061(19970315)13:3<233::aid-yea88>3.0.co
Autor:
Kristin T. Chun, Mark G. Goebl
Publikováno v:
Genetics. 142:39-50
The yeast Saccharomyces cerevisiae reproduces by budding, and many genes are required for proper bud development. Mutations in some of these genes cause cells to die with an unusual terminal morphology—elongated or otherwise aberrantly shaped buds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6196a13994fe1fd1d51e44873a670f
https://doi.org/10.1093/genetics/142.1.39
https://doi.org/10.1093/genetics/142.1.39
Autor:
W. Scott Goebel, Nan Jia, Kristin T. Chun, Binghui Li, Yahaira Naaldijk, David L. Waning, Harm HogenEsch
Publikováno v:
Blood. 112(2)
In vitro studies indicate that Cul4A ubiquitin ligases target for ubiquitin-mediated proteolysis regulators of cell-cycle progression, apoptosis, development, and DNA repair. In hematopoietic cell lines, studies by our group and others showed that Cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67d0dc865f3c147b17d634048cd3343
https://pubmed.ncbi.nlm.nih.gov/18606878
https://pubmed.ncbi.nlm.nih.gov/18606878
Autor:
Jeong Heon Lee, Binghui Li, Laura S. Haneline, Harm HogenEsch, Shehnaz Khan, David G. Skalnik, Erika A. Dobrota, Kristin T. Chun, Courtney M. Tate
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 12, p e113745 (2014)
PLoS ONE, Vol 9, Iss 12, p e113745 (2014)
CXXC finger protein 1 (Cfp1), encoded by the Cxxc1 gene, binds to DNA sequences containing an unmethylated CpG dinucleotide and is an epigenetic regulator of both cytosine and histone methylation. Cxxc1-null mouse embryos fail to gastrulate, and Cxxc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fd1544c8f59fb492d1862d79f3add2
https://doi.org/10.1371/journal.pone.0113745
https://doi.org/10.1371/journal.pone.0113745