Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kristin Strumane"'
Autor:
Simone C. Oostindie, Hilma J. van der Horst, Margaret A. Lindorfer, Erika M. Cook, Jillian C. Tupitza, Clive S. Zent, Richard Burack, Karl R. VanDerMeid, Kristin Strumane, Martine E. D. Chamuleau, Tuna Mutis, Rob N. de Jong, Janine Schuurman, Esther C. W. Breij, Frank J. Beurskens, Paul W. H. I. Parren, Ronald P. Taylor
Publikováno v:
Haematologica, Vol 104, Iss 9 (2019)
CD20 monoclonal antibody therapies have significantly improved the outlook for patients with B-cell malignancies. However, many patients acquire resistance, demonstrating the need for new and improved drugs. We previously demonstrated that the natura
Externí odkaz:
https://doaj.org/article/8951ab20ead14f0a871191432d4962ce
Autor:
Rob N de Jong, Frank J Beurskens, Sandra Verploegen, Kristin Strumane, Muriel D van Kampen, Marleen Voorhorst, Wendy Horstman, Patrick J Engelberts, Simone C Oostindie, Guanbo Wang, Albert J R Heck, Janine Schuurman, Paul W H I Parren
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002344 (2016)
IgG antibodies can organize into ordered hexamers on cell surfaces after binding their antigen. These hexamers bind the first component of complement C1 inducing complement-dependent target cell killing. Here, we translated this natural concept into
Externí odkaz:
https://doaj.org/article/bfabba60d9884594bbcd39074b399b29
Autor:
Esther C.W. Breij, Rob N. de Jong, Paul W.H.I. Parren, Janine Schuurman, Ulf Forssmann, Andreas Lingnau, Richard G. Hibbert, Naomi Hoevenaars, Bart de Jong, Thessa Kroes, Boris S. Vuillermoz, Claudine Vermot-Desroches, Antonio Ortiz Buijsse, Frank J. Beurskens, Kristin Strumane, Marije B. Overdijk
Supplemental Tables Supplemental Figures Supplemental Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc0742629adc9c9f5ee0bce476596b4
https://doi.org/10.1158/1535-7163.22520991.v1
https://doi.org/10.1158/1535-7163.22520991.v1
Autor:
Esther C.W. Breij, Rob N. de Jong, Paul W.H.I. Parren, Janine Schuurman, Ulf Forssmann, Andreas Lingnau, Richard G. Hibbert, Naomi Hoevenaars, Bart de Jong, Thessa Kroes, Boris S. Vuillermoz, Claudine Vermot-Desroches, Antonio Ortiz Buijsse, Frank J. Beurskens, Kristin Strumane, Marije B. Overdijk
Higher-order death receptor 5 (DR5) clustering can induce tumor cell death; however, therapeutic compounds targeting DR5 have achieved limited clinical efficacy. We describe HexaBody-DR5/DR5, an equimolar mixture of two DR5-specific IgG1 antibodies w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f853ed6f8830a1d4904eeb661710e2
https://doi.org/10.1158/1535-7163.c.6542862.v1
https://doi.org/10.1158/1535-7163.c.6542862.v1
Autor:
Frans van Roy, Geert Berx, Philippe Birembaut, Marc Mareel, Erik Bruyneel, Beatrice Nawrocki-Raby, Roosmarijn Vandenbroucke, Christophe Stove, Arnaud Bonnomet, Kristin Strumane
Supplementary Figure 2 from E-Cadherin Regulates Human Nanos1, which Interacts with p120ctn and Induces Tumor Cell Migration and Invasion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7858562cb42551f2bec28ba5ccab0bac
https://doi.org/10.1158/0008-5472.22364298.v1
https://doi.org/10.1158/0008-5472.22364298.v1
Autor:
Frans van Roy, Geert Berx, Philippe Birembaut, Marc Mareel, Erik Bruyneel, Beatrice Nawrocki-Raby, Roosmarijn Vandenbroucke, Christophe Stove, Arnaud Bonnomet, Kristin Strumane
Supplementary Methods, Materials and Figure Legends 1-2 from E-Cadherin Regulates Human Nanos1, which Interacts with p120ctn and Induces Tumor Cell Migration and Invasion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4f4945ffc23929f20f8b1347a02002
https://doi.org/10.1158/0008-5472.22364295.v1
https://doi.org/10.1158/0008-5472.22364295.v1
Autor:
Frans van Roy, Geert Berx, Philippe Birembaut, Marc Mareel, Erik Bruyneel, Beatrice Nawrocki-Raby, Roosmarijn Vandenbroucke, Christophe Stove, Arnaud Bonnomet, Kristin Strumane
Supplementary Figure 1 from E-Cadherin Regulates Human Nanos1, which Interacts with p120ctn and Induces Tumor Cell Migration and Invasion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be64635849025d7a7467e39f7f9dd94
https://doi.org/10.1158/0008-5472.22364301.v1
https://doi.org/10.1158/0008-5472.22364301.v1
Autor:
Frans van Roy, Geert Berx, Philippe Birembaut, Marc Mareel, Erik Bruyneel, Beatrice Nawrocki-Raby, Roosmarijn Vandenbroucke, Christophe Stove, Arnaud Bonnomet, Kristin Strumane
Down-regulation of the epithelial cell-cell adhesion molecule E-cadherin is frequently associated with tumor formation and progression. Besides its role in physical cell-cell adhesion, E-cadherin is also thought to be involved in intracellular signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5505268ef4142d96d6ecb6c1c0403b20
https://doi.org/10.1158/0008-5472.c.6494124
https://doi.org/10.1158/0008-5472.c.6494124
Autor:
Kristina Nürmberger, Andrea Imle, Aras Toker, Kristin Strumane, Sina Fellermeier-Kopf, Andreea Ioan-Facsinay, Alexander Muik, Mustafa Diken, Frank Beurskens, Rob De Jong, Sebastian Kreiter, David Satijn, Friederike Gieseke, Janine Schuurman, Tahamtam Ahmadi, Oezlem Tuereci, Kate Sasser, Esther Breij, Ugur Sahin, Isil Altinas
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Janine Schuurman, Martine E.D. Chamuleau, Paul W. H. I. Parren, Jeroen van den Brakel, Ronald P. Taylor, Marije B. Overdijk, Hilma J. van der Horst, Simone C. Oostindie, Hendrik J. Rademaker, Frank J. Beurskens, Juliette van den Noort, Berris van Kessel, Esther C.W. Breij, Margaret A. Lindorfer, Kristin Strumane, Laurens P. Kil, Tuna Mutis, Edward Van Den Brink
Publikováno v:
Blood Cancer Journal, 10(3). NATURE PUBLISHING GROUP
Oostindie, S C, van der Horst, H J, Kil, L P, Strumane, K, Overdijk, M B, van den Brink, E N, van den Brakel, J H N, Rademaker, H J, van Kessel, B, van den Noort, J, Chamuleau, M E D, Mutis, T, Lindorfer, M A, Taylor, R P, Schuurman, J, Parren, P W H I, Beurskens, F J & Breij, E C W 2020, ' DuoHexaBody-CD37 ®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies ', Blood cancer journal, vol. 10, no. 3, 30 . https://doi.org/10.1038/s41408-020-0292-7
Blood cancer journal, 10(3):30. Nature Publishing Group
Blood Cancer Journal, Vol 10, Iss 3, Pp 1-13 (2020)
Oostindie, S C, van der Horst, H J, Kil, L P, Strumane, K, Overdijk, M B, van den Brink, E N, van den Brakel, J H N, Rademaker, H J, van Kessel, B, van den Noort, J, Chamuleau, M E D, Mutis, T, Lindorfer, M A, Taylor, R P, Schuurman, J, Parren, P W H I, Beurskens, F J & Breij, E C W 2020, ' DuoHexaBody-CD37 ®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies ', Blood cancer journal, vol. 10, no. 3, 30 . https://doi.org/10.1038/s41408-020-0292-7
Blood cancer journal, 10(3):30. Nature Publishing Group
Blood Cancer Journal, Vol 10, Iss 3, Pp 1-13 (2020)
Tetraspanin CD37 has recently received renewed interest as a therapeutic target for B-cell malignancies. Although complement-dependent cytotoxicity (CDC) is a powerful Fc-mediated effector function for killing hematological cancer cells, CD37-specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0286279d1b9ed42c80861ce3d6a052
https://www.nature.com/articles/s41408-020-0292-7
https://www.nature.com/articles/s41408-020-0292-7