Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kristin Spaich"'
Autor:
Dorothea Kehr, Julia Ritterhoff, Manuel Glaser, Lukas Jarosch, Rafael E. Salazar, Kristin Spaich, Karl Varadi, Jennifer Birkenstock, Michael Egger, Erhe Gao, Walter J. Koch, Hugo A. Katus, Norbert Frey, Andreas Jungmann, Cornelius Busch, Paul J. Mather, Arjang Ruhparwar, Mirko Völkers, Rebecca C. Wade, Patrick Most
BackgroundThe EF-hand Ca2+sensor protein S100A1 has been identified as a molecular regulator and enhancer of cardiac performance. S100A1’s ability to recognize and modulate the activity of targets such as SERCA2a and RyR2 in cardiomyocytes has most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecb3004b44244dbaf42749e450e246fb
https://doi.org/10.1101/2023.03.04.531024
https://doi.org/10.1101/2023.03.04.531024
Autor:
Karsten Peppel, Erhe Gao, Rainer H. A. Fink, Hugo A. Katus, Kristin Spaich, Wolfram H. Zimmermann, Sven T. Pleger, Oliver Friedrich, Andreas Seitz, Patrick Most, Mirko Völkers, Julia Ritterhoff, Walter J. Koch
Publikováno v:
Molecular Therapy. 23:1320-1330
Restoring expression levels of the EF-hand calcium (Ca(2+)) sensor protein S100A1 has emerged as a key factor in reconstituting normal Ca(2+) handling in failing myocardium. Improved sarcoplasmic reticulum (SR) function with enhanced Ca(2+) resequest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdd7784d8373cea274afe0f9975e2f3
https://doi.org/10.1038/mt.2015.93
https://doi.org/10.1038/mt.2015.93
Autor:
Walter J. Koch, Hans-Jörg Hippe, Christian Weidenhammer, Patrick Most, Andrea D. Eckhart, Oliver J. Müller, Henriette Brinks, Frederic von Wegner, Oliver Friedrich, Joseph E. Rabinowitz, Kristin Spaich, Mirko Völkers, Hugo A. Katus, Stefanie Schinkel, Karsten Peppel, Nicole Herzog, Gang Qiu
Publikováno v:
Circulation Research. 108:27-39
Rationale: The G βγ -sequestering peptide β-adrenergic receptor kinase (βARK)ct derived from the G-protein–coupled receptor kinase (GRK)2 carboxyl terminus has emerged as a promising target for gene-based heart failure therapy. Enhanced downstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126f71334e9f1550f4ff86638a6d725b
https://doi.org/10.1161/circresaha.110.225201
https://doi.org/10.1161/circresaha.110.225201
Autor:
Julia Ritterhoff, Mirko Völkers, Andreas Seitz, Kristin Spaich, Karten Peppel, Sven Pleger, Wolfram Zimmermann, Oliver Friedrich, Rainer Fink, Walter Koch, Hugo Katus, Patrick Most
Publikováno v:
Circulation Research. 115
S100A1 has emerged as a key factor in the control of cardiomyocyte (CM) contractile performance. Improved sarcoplasmic reticulum (SR) function with enhanced Ca2+ resequestration appears critical for its cAMP-independent inotropic effects but raises c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a77452ba45ad61ce72cec27298da5e3e
https://doi.org/10.1161/res.115.suppl_1.37
https://doi.org/10.1161/res.115.suppl_1.37