Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kristin S. Ko"'
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease related to the deposition of aggregated amyloid-β (Aβ) peptides in the brain. It has been proposed that metal ion dyshomeostasis and miscompartmentalization contribute to AD pro
Externí odkaz:
https://doaj.org/article/a2aad99fb2c14aabbd13b9207c6210a1
Autor:
Jeremy Monroe, Daniel E. Eyler, Lili Mitchell, Indrajit Deb, Abigail Bojanowski, Pooja Srinivas, Christine M. Dunham, Bijoyita Roy, Aaron T. Frank, Kristin S. Koutmou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The ribosome utilizes hydrogen bonding between mRNA codons and aminoacyl-tRNAs to ensure rapid and accurate protein production. Chemical modification of mRNA nucleobases can adjust the strength and pattern of this hydrogen bonding to alter p
Externí odkaz:
https://doaj.org/article/50975c01401849b98fd36770145e907c
Autor:
Taylor K. Johnson, Sameer Phadke, Michael P. Agius, Kristin S. Ko, Matthew B. Soellner, Frank E. Kwarcinski, Eric J. Lachacz
Publikováno v:
ACS Chem Biol
Protein kinase pathways are traditionally mapped by monitoring downstream phosphorylation. Meanwhile, the non-catalytic functions of protein kinases remain under-appreciated as critical components of kinase signaling. c-Src is a protein kinase known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20754ecfeef4d31990642276eaac37cc
https://europepmc.org/articles/PMC7254491/
https://europepmc.org/articles/PMC7254491/
Autor:
Anna Nemudraia, Artem Nemudryi, Murat Buyukyoruk, Andrew M. Scherffius, Trevor Zahl, Tanner Wiegand, Shishir Pandey, Joseph E. Nichols, Laina N. Hall, Aidan McVey, Helen H. Lee, Royce A. Wilkinson, Laura R. Snyder, Joshua D. Jones, Kristin S. Koutmou, Andrew Santiago-Frangos, Blake Wiedenheft
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Many viral diagnostic approaches require nucleic acid extraction and amplification prior to detection. Here, the authors develop a method based on type III CRISPR systems which allows sequence specific capture, concentration, and detection of viral R
Externí odkaz:
https://doaj.org/article/ec88a12a41b642dfb6cdf759b457932d
Autor:
Suk Joon Hyung, Matthew B. Soellner, Christel C. Fox, Kristin S. Ko, Brandon T. Ruotolo, Jessica N. Rabuck
Publikováno v:
Analytical Chemistry. 85:6995-7002
The discovery of activation state dependent kinase inhibitors, which bind specifically to the inactive conformation of the protein, is considered to be a promising pathway to improved cancer treatments. Identifying such inhibitors is challenging, how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a087783c2cb7d3a0a4db9322d43512
https://doi.org/10.1021/ac4012655
https://doi.org/10.1021/ac4012655
Autor:
Anthony J. Berdis, Jennifer Fishovitz, Kristin S. Ko, Hilary Frase, Min Li, Sandra Craig, Carolyn K. Suzuki, Irene Lee, Jason E. Hudak
Publikováno v:
ACS Chemical Biology. 6:781-788
Lon and ClpXP are the only soluble ATP-dependent proteases within the mammalian mitochondria matrix, which function in protein quality control by selectively degrading misfolded, misassembled, or damaged proteins. Chemical tools to study these protea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3833c9bfb3c1a5f92204097e2e7e6a8a
https://doi.org/10.1021/cb100408w
https://doi.org/10.1021/cb100408w
Autor:
Lawrence M. Sayre, Karin Ernberg, Yen Hoang Le Nguyen, Larry Miller, Bo Zhong, Irene Lee, J. Mitchell Guss, Kristin S. Ko
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1814:638-646
Copper amine oxidases (CAOs) are a family of redox active enzymes containing a 2,4,5-trihydroxyphenylalanine quinone (TPQ) cofactor generated from post translational modification of an active site tyrosine residue. The Arthrobacter globiformis amine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fbe254eaf1107b82d6065110655a8e
https://doi.org/10.1016/j.bbapap.2010.12.016
https://doi.org/10.1016/j.bbapap.2010.12.016
Publikováno v:
ACS medicinal chemistry letters. 4(8)
On the basis of synergism observed between a selective c-Src kinase inhibitor with an HDAC inhibitor, the development of the first chimeric c-Src kinase and HDAC inhibitor is described. The optimized chimeric inhibitor is shown to be a potent c-Src a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf37da482c15cacceabfeccb684829c
https://pubmed.ncbi.nlm.nih.gov/24015327
https://pubmed.ncbi.nlm.nih.gov/24015327
Publikováno v:
MedChemComm. 2:1099
The design of multifunctional, neuroprotective compounds has received increasing attention due to their perceived utility in targeting not only the diverse comorbidity of neurological disorders, but also the typically complex pathoetiological pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31ccf5bf4399d04cc8b9459cc6a02ae6
https://doi.org/10.1039/c1md00176k
https://doi.org/10.1039/c1md00176k