Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Kristin S Koutmou"'
Autor:
Kehan Bao, Chun-Min Shan, Xiao Chen, Gulzhan Raiymbek, Jeremy G Monroe, Yimeng Fang, Takenori Toda, Kristin S Koutmou, Kaushik Ragunathan, Chao Lu, Luke E Berchowitz, Songtao Jia
Publikováno v:
PLoS Genetics, Vol 18, Iss 2, p e1010049 (2022)
The epigenetic landscape of a cell frequently changes in response to fluctuations in nutrient levels, but the mechanistic link is not well understood. In fission yeast, the JmjC domain protein Epe1 is critical for maintaining the heterochromatin land
Externí odkaz:
https://doaj.org/article/1c262db5a8464ee0a433fff8500f564e
Autor:
Jeremy Monroe, Daniel E. Eyler, Lili Mitchell, Indrajit Deb, Abigail Bojanowski, Pooja Srinivas, Christine M. Dunham, Bijoyita Roy, Aaron T. Frank, Kristin S. Koutmou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The ribosome utilizes hydrogen bonding between mRNA codons and aminoacyl-tRNAs to ensure rapid and accurate protein production. Chemical modification of mRNA nucleobases can adjust the strength and pattern of this hydrogen bonding to alter p
Externí odkaz:
https://doaj.org/article/50975c01401849b98fd36770145e907c
Autor:
Kristin S Koutmou, Anthony P Schuller, Julie L Brunelle, Aditya Radhakrishnan, Sergej Djuranovic, Rachel Green
Publikováno v:
eLife, Vol 4 (2015)
Protein output from synonymous codons is thought to be equivalent if appropriate tRNAs are sufficiently abundant. Here we show that mRNAs encoding iterated lysine codons, AAA or AAG, differentially impact protein synthesis: insertion of iterated AAA
Externí odkaz:
https://doaj.org/article/72f2c8d9511d4ac699f475ae925f7955
Autor:
Anna Nemudraia, Artem Nemudryi, Murat Buyukyoruk, Andrew M. Scherffius, Trevor Zahl, Tanner Wiegand, Shishir Pandey, Joseph E. Nichols, Laina N. Hall, Aidan McVey, Helen H. Lee, Royce A. Wilkinson, Laura R. Snyder, Joshua D. Jones, Kristin S. Koutmou, Andrew Santiago-Frangos, Blake Wiedenheft
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Many viral diagnostic approaches require nucleic acid extraction and amplification prior to detection. Here, the authors develop a method based on type III CRISPR systems which allows sequence specific capture, concentration, and detection of viral R
Externí odkaz:
https://doaj.org/article/ec88a12a41b642dfb6cdf759b457932d
Autor:
Joshua D. Jones, Kathleen T. Grassmyer, Robert T. Kennedy, Kristin S. Koutmou, Todd D. Maloney
Publikováno v:
Analytical Chemistry. 95:4404-4411
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c1fd1224fb3b449e5cddd06a0a98117
https://doi.org/10.1021/acs.analchem.2c04902
https://doi.org/10.1021/acs.analchem.2c04902
Autor:
Joshua D. Jones, Monika K. Franco, Tyler J. Smith, Laura R. Snyder, Anna G. Anders, Brandon T. Ruotolo, Robert T. Kennedy, Kristin S. Koutmou
Publikováno v:
RSC Chemical Biology. 4:363-378
Chemical modifications to protein encoding messenger RNA (mRNA) can modulate their localization, translation and stability within cells. Over 15 different types of mRNA modifications have been identified by sequencing and liquid chromatography couple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acfa3a5a15d6b71ba6c7ee0344b67c3
https://doi.org/10.1039/d2cb00229a
https://doi.org/10.1039/d2cb00229a
Autor:
Solaire A. Finkenstaedt-Quinn, Nicholas F. Garza, Catherine A. Wilhelm, Kristin S. Koutmou, Ginger V. Shultz
Publikováno v:
Journal of Chemical Education. 99:3386-3395
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84842d2509a797c285f09fbf11a2c8ba
https://doi.org/10.1021/acs.jchemed.2c00171
https://doi.org/10.1021/acs.jchemed.2c00171
Autor:
Rebecca Meyer-Schuman, Sheila Marte, Tyler J. Smith, Shawna M.E. Feely, Marina Kennerson, Garth Nicholson, Mike E. Shy, Kristin S. Koutmou, Anthony Antonellis
Publikováno v:
Human Molecular Genetics.
Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed, essential enzymes that ligate tRNA molecules to their cognate amino acids. Heterozygosity for missense variants or small in-frame deletions in five ARS genes causes axonal peripheral neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c6c8f57e067217c5125f5667dc5ac0
https://doi.org/10.1093/hmg/ddad054
https://doi.org/10.1093/hmg/ddad054
Publikováno v:
Nature biotechnology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::324dd3dec6f76aaa68dc8c7dd5019d6a
https://pubmed.ncbi.nlm.nih.gov/36302991
https://pubmed.ncbi.nlm.nih.gov/36302991
Autor:
Shannon E Wright, Caitlin M Rodriguez, Jeremy Monroe, Jiazheng Xing, Amy Krans, Brittany N Flores, Venkatesha Barsur, Magdalena I Ivanova, Kristin S Koutmou, Sami J Barmada, Peter K Todd
Publikováno v:
Nucleic acids research. 50(15)
CGG repeat expansions in the FMR1 5’UTR cause the neurodegenerative disease Fragile X-associated tremor/ataxia syndrome (FXTAS). These repeats form stable RNA secondary structures that support aberrant translation in the absence of an AUG start cod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45255f7e330a7946680d7a13db7d4bd4
https://pubmed.ncbi.nlm.nih.gov/35904811
https://pubmed.ncbi.nlm.nih.gov/35904811