Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kristin Pogoda"'
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 918 (2023)
The calcium sensitizer levosimendan is used for the treatment of acute decompensated heart failure. A small portion (4–7%) of levosimendan is metabolized to the pharmacologically active metabolite OR-1896 via the inactive intermediate OR-1855. In a
Externí odkaz:
https://doaj.org/article/3b5dcf8b24374f9ab70bed4f090ebc45
Autor:
Martin Bernhard Müller, Max Hübner, Lei Li, Stephanie Tomasi, Valena Ließke, David Effinger, Simon Hirschberger, Kristin Pogoda, Markus Sperandio, Simone Kreth
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Opening of the endothelial barrier and targeted infiltration of leukocytes into the affected tissue are hallmarks of the inflammatory response. The molecular mechanisms regulating these processes are still widely elusive. In this study, we elucidate
Externí odkaz:
https://doaj.org/article/91faa68c6d4f4bfaa6b92f0658812ab5
Autor:
Yvonn Heun, Joachim Pircher, Thomas Czermak, Philipp Bluem, Georg Hupel, Monica Bohmer, Bjoern F. Kraemer, Kristin Pogoda, Alexander Pfeifer, Markus Woernle, Andrea Ribeiro, Max Hübner, Simone Kreth, Ralf A. Claus, Sebastian Weis, Luisa Ungelenk, Florian Krötz, Ulrich Pohl, Hanna Mannell
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 120-132 (2019)
Background: Sepsis, the most severe form of infection, involves endothelial dysfunction which contributes to organ failure. To improve therapeutic prospects, elucidation of molecular mechanisms underlying endothelial vascular failure is of essence. M
Externí odkaz:
https://doaj.org/article/78b587040038484299b00611b43f6d90
Autor:
Petra Kameritsch, Kristin Pogoda
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
During acute inflammation, the recruitment of leukocytes from the blood stream into the inflamed tissue is a well-described mechanism encompassing the interaction of endothelial cells with leukocytes allowing leukocytes to reach the site of tissue in
Externí odkaz:
https://doaj.org/article/6c760ecd66044800abaa32fb5ecd4a15
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Actin-dependent leukocyte trafficking and activation are critical for immune surveillance under steady state conditions and during disease states. Proper immune surveillance is of utmost importance in mammalian homeostasis and it ensures the defense
Externí odkaz:
https://doaj.org/article/08c027c232c9454389a634bac1915453
Autor:
Stephanie Tomasi, Lei Li, Ludwig Christian Hinske, Roland Tomasi, Martina Amini, Gabriele Strauß, Martin Bernhard Müller, Simon Hirschberger, Sven Peterss, David Effinger, Kristin Pogoda, Simone Kreth, Max Hübner
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10684
During the onset of acute inflammation, rapid trafficking of leukocytes is essential to mount appropriate immune responses towards an inflammatory insult. Monocytes are especially indispensable for counteracting the inflammatory stimulus, neutralisin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0cf79efb187fee165dbc75d0edf215
https://pubmed.ncbi.nlm.nih.gov/36142632
https://pubmed.ncbi.nlm.nih.gov/36142632
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 294
International Journal of Molecular Sciences, Vol 23, Iss 294, p 294 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 294
International Journal of Molecular Sciences, Vol 23, Iss 294, p 294 (2022)
The gap junction protein connexin 43 (Cx43) is associated with increased cell migration and to related changes of the actin cytoskeleton, which is mediated via its C-terminal cytoplasmic tail and is independent of its channel function. Cx43 has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db723b7d96ce6f9ea1591bd7a84945ef
http://europepmc.org/articles/PMC8745637
http://europepmc.org/articles/PMC8745637
Autor:
Petra Kameritsch, Kristin Pogoda
Publikováno v:
Current Opinion in Pharmacology. 45:16-22
Myoendothelial gap junctions are involved in the regulation of vascular tone. The major connexins described in the vascular system are Cx37, Cx40, Cx43, and Cx45 with all but Cx45 found in myoendothelial connections. Although many reports on post-tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c2c41a5ee020e400286aa7efab5351
https://doi.org/10.1016/j.coph.2019.03.006
https://doi.org/10.1016/j.coph.2019.03.006
Autor:
Marcus Conrad, Ruicen Cui, Julian Kirsch, Rafael Radi, Petra Kameritsch, Thomas Kirchner, Christoph Nuernbergk, Heike Beck, Holger Schneider, Susanna Müller, Aníbal M. Reyes, Miriam Singer, Ulrich Pohl, Kjestine Schmidt, Cor de Wit, Natalia Rios, Bärbel Lange-Sperandio, Kristin Pogoda
Publikováno v:
Proc Natl Acad Sci U S A
The mitochondrial thioredoxin/peroxiredoxin system encompasses NADPH, thioredoxin reductase 2 (TrxR2), thioredoxin 2, and peroxiredoxins 3 and 5 (Prx3 and Prx5) and is crucial to regulate cell redox homeostasis via the efficient catabolism of peroxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ad0613087c3ad24b4de4474aff2481
https://doi.org/10.1073/pnas.1921828118
https://doi.org/10.1073/pnas.1921828118
Autor:
Friedrich-Wilhelm Kreth, Max Hübner, David Effinger, Simone Kreth, Kristin Pogoda, Gabriele Strauß, Tingting Wu
Publikováno v:
Cancers
Cancers, Vol 12, Iss 2, p 433 (2020)
Volume 12
Issue 2
Cancers, Vol 12, Iss 2, p 433 (2020)
Volume 12
Issue 2
Background: The recombinant IL-1 receptor antagonist anakinra&mdash
currently approved for the treatment of autoinflammatory diseases&mdash
blocks IL-1&beta
mediated inflammatory signaling. As inflammation is a major driver of cancer,
currently approved for the treatment of autoinflammatory diseases&mdash
blocks IL-1&beta
mediated inflammatory signaling. As inflammation is a major driver of cancer,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ecb7e0749bff6d1cf9f8c72bb358f3a
http://europepmc.org/articles/PMC7072290
http://europepmc.org/articles/PMC7072290