Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kristin Panwell"'
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
Metastatic disease in pheochromocytomas and paragangliomas (PCC/PGL) is not well-understood. The Cancer Genome Atlas discovered recurrent MAML3 fusion genes in a subset of tumors that lacked known germline or somatic driver mutations and were associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::674750c2959d14a74db7c61f10663f20
https://doi.org/10.1158/1541-7786.c.6545123.v1
https://doi.org/10.1158/1541-7786.c.6545123.v1
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
MAML3 overexpression has no effect on proliferation or apoptotic signaling. SK-N-SH, QGP-1 and BON-1 transfected with FL or dEx1 MAML3 and showed A) no increase in proliferation by BrdU assay when grown in full serum media for 72 hours and B) no incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce28523047fb39b8d33c486783b1d49
https://doi.org/10.1158/1541-7786.22526531.v1
https://doi.org/10.1158/1541-7786.22526531.v1
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
MAML3 increases cell viability. SK-N-SH, QGP-1 and BON-1 transfected with FL or dEx1 MAML3 showed increased cell viability by Cell Titer Glo assay (* p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43eb7ceee271ddfe1b3e8b924d6642e
https://doi.org/10.1158/1541-7786.22526528
https://doi.org/10.1158/1541-7786.22526528
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
MAML3 in vitro cellular localization for QGP-1 and BON-1. Immunofluorescence of cells transfected with either FL or dEx1 MAML3 show nuclear localization of both constructs. FL MAML3 shows more punctate staining and dEx1 MAML3 shows more diffuse stain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819282a023f90d06f7de95657a526e1a
https://doi.org/10.1158/1541-7786.22526534
https://doi.org/10.1158/1541-7786.22526534
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
β-catenin interacts with dEx1 MAML3. Neuroendocrine tumor cell lines were co-transfected with β-catenin and dEx1 MAML3. Immunoprecipitation of MAML3 demonstrated co-precipitation of β-catenin in QGP-1 and BON-1, but not in SK-N-SH (not shown). B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636ec59d80d249412f1bb00e61adc8b0
https://doi.org/10.1158/1541-7786.22526519
https://doi.org/10.1158/1541-7786.22526519
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
β-catenin and FL or dEx1 MAML3 colocalize in the nucleus. Cell lines (A. SK-N-SH, B. QGP-1, C. BON-1) were co-transfected with either FL or dEx1 MAML3 and β-catenin or control plasmid. Cells overexpressing FL or dEx1 MAML3 alone showed some faint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bf0d22e47afbb8e57b06126fef87dd
https://doi.org/10.1158/1541-7786.22526522
https://doi.org/10.1158/1541-7786.22526522
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
C6 Oncogenic pathway analysis. GSEA of MAML3 dEx1 and FL transfected cells compared to control showed dysregulation of WNT and SHH signaling pathways. Filled circles represent an adjusted p value of less than 0.05, whereas empty circles represent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75844d521e93574da2ef9cbb51048e26
https://doi.org/10.1158/1541-7786.22526513.v1
https://doi.org/10.1158/1541-7786.22526513.v1
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
Western blot for expression of FL and dEx1 MAML3 domain constructs and luciferase assay. Cells for these blots were transfected at the same time as cells used for the luciferase experiment and harvested on the day the luciferase assay was performed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d201f42f7885a5c7d53ff802a45ee53
https://doi.org/10.1158/1541-7786.22526516.v1
https://doi.org/10.1158/1541-7786.22526516.v1
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
Table S1 has the RNA-Seq sample names and raw counts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11eb49a6bb7f8f13dd356fe0443a1f83
https://doi.org/10.1158/1541-7786.22526510
https://doi.org/10.1158/1541-7786.22526510
Autor:
Katrina Koc, Katherine L. Nathanson, Debbie L. Cohen, Maria Albuja-Cruz, Kristin Panwell, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Lauren Fishbein, Nathaniel Alzofon, Christopher D. Raeburn, Nikita Pozdeyev, Carrie Marshall
Publikováno v:
Mol Cancer Res
Metastatic disease in pheochromocytomas and paragangliomas (PCC/PGL) is not well-understood. The Cancer Genome Atlas discovered recurrent MAML3 fusion genes in a subset of tumors that lacked known germline or somatic driver mutations and were associa