Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Autor: Johannes Steffen, Markus Krohn, Christina Schwitlick, Thomas Brüning, Kristin Paarmann, Claus U. Pietrzik, Henrik Biverstål, Baiba Jansone, Oliver Langer, Jens Pahnke

Publikováno v: Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-9 (2017)

Abstract Amyloid-β (Aβ) deposition is one of the hallmarks of the amyloid hypothesis in Alzheimer’s disease (AD). Mouse models using APP-transgene overexpression to generate amyloid plaques have shown to model only certain parts of the disease. T

Externí odkaz: https://doaj.org/article/316f833d2d054e82828c91fe072bb6e9

Detection and Prediction of Mild Cognitive Impairment in Alzheimer's Disease Mice

Autor: Markus Krohn, Surya Prakash Rai, Pablo Bascuñana, Kristin Paarmann, Mirjam Brackhan, Jens Pahnke, Luisa Möhle

Publikováno v: Journal of Alzheimer's Disease

Background: The recent failure of clinical trials to treat Alzheimer’s disease (AD) indicates that the current approach of modifying disease is either wrong or is too late to be efficient. Mild cognitive impairment (MCI) denotes the phase between t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b545ecb3b2b427cdac88cc380090d1a5
http://hdl.handle.net/10852/81359

French maritime pine bark treatment decelerates plaque development and improves spatial memory in Alzheimer's disease mice

Autor: Thomas Brüning, Kristin Paarmann, Luisa Möhle, Jens Pahnke, Mirjam Brackhan, SR Prakash, Markus Krohn, Ivan Eiriz

Publikováno v: Phytomedicine

Background Plant extracts are increasingly investigated as potential drugs against Alzheimer's disease (AD) and dementia in general. Pycnogenol is an extract from the bark of the French maritime pine (Pinus pinaster Aiton subsp. atlantica) with known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a3b287682ed5187c069a6ead9cf5ee

Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes

Autor: Luisa Möhle, Eckart D. Gundelfinger, Björn H. Schott, Sabine Pietkiewicz, Ulrike Seifert, Dirk Schlüter, Kristin Paarmann, Dirk Montag, Nicole Israel, Inna N. Lavrik, Jens Pahnke, Jeffrey S. Buguliskis, Andreas Müller, Markus Krohn, Ildiko Rita Dunay

Publikováno v: Acta Neuropathologica Communications 4(1), 25 (2016). doi:10.1186/s40478-016-0293-8
Acta Neuropathologica Communications
Acta Neuropathologica Communications, 4:25

Introduction Alzheimer’s disease (AD) is associated with the accumulation of β-amyloid (Aβ) as senile plaques in the brain, thus leading to neurodegeneration and cognitive impairment. Plaque formation depends not merely on the amount of generated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5cc3d51eeed280b8efe8d4c2828a18
https://pub.dzne.de/record/138459

Accumulation of murine amyloid-β mimics early Alzheimer's disease

Autor: Alexander Bracke, Jacqueline Hofrichter, Oliver von Bohlen und Halbach, Cathleen Lange, Yosef Avchalumov, Markus Krohn, Toni Schumacher, Kristin Paarmann, Jens Pahnke, Christina Fröhlich, Thomas Brüning

Publikováno v: Brain : a journal of neurology. 138(Pt 8)

Amyloidosis mouse models of Alzheimer’s disease are generally established by transgenic approaches leading to an overexpression of mutated human genes that are known to be involved in the generation of amyloid-β in Alzheimer’s families. Although

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64eb5951fba675ea2f64884e93ab864c
https://pubmed.ncbi.nlm.nih.gov/25991605