P-glycoprotein modulates morphine uptake into the CNS: a role for the non-steroidal anti-inflammatory drug diclofenac.

Autor: Lucy Sanchez-Covarrubias, Lauren M Slosky, Brandon J Thompson, Yifeng Zhang, Mei-Li Laracuente, Kristin M DeMarco, Patrick T Ronaldson, Thomas P Davis

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88516 (2014)

Our laboratory has previously demonstrated that peripheral inflammatory pain (PIP), induced by subcutaneous plantar injection of λ-carrageenan, results in increased expression and activity of the ATP-dependent efflux transporter P-glycoprotein (P-gp

Externí odkaz: https://doaj.org/article/fd44c9292b344d9f9cf6f3bbff866d47

Inflammatory Pain Signals an Increase in Functional Expression of Organic Anion Transporting Polypeptide 1a4 at the Blood-Brain Barrier

Autor: Jessica D. Finch, Patrick T. Ronaldson, Thomas P. Davis, Colleen E. Quigley, Kristin M. DeMarco

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 336:827-839

Pain is a dominant symptom associated with inflammatory conditions. Pharmacotherapy with opioids may be limited by poor blood-brain barrier (BBB) permeability. One approach that may improve central nervous system (CNS) delivery is to target endogenou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41b0f634a3fd2af65e190ca412b5c4f
https://doi.org/10.1124/jpet.110.174151

Oxidative stress increases blood–brain barrier permeability and induces alterations in occludin during hypoxia–reoxygenation

Autor: Jessica D. Finch, Thomas P. Davis, Colleen E. Quigley, Gwen McCaffrey, Nicole Nametz, Jeffrey J. Lochhead, Kristin M. DeMarco

The blood–brain barrier (BBB) has a critical role in central nervous system homeostasis. Intercellular tight junction (TJ) protein complexes of the brain microvasculature limit paracellular diffusion of substances from the blood into the brain. Hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bd4bb6782ecd308a9f3fcad665544f
https://europepmc.org/articles/PMC3049533/

P-glycoprotein Modulates Morphine Uptake into the CNS: A Role for the Non-steroidal Anti-inflammatory Drug Diclofenac.

Autor: Sanchez-Covarrubias, Lucy¹, Slosky, Lauren M.¹, Thompson, Brandon J.¹, Zhang, Yifeng¹, Laracuente, Mei-Li¹, DeMarco, Kristin M.¹, Ronaldson, Patrick T.¹, Davis, Thomas P.¹ davistp@email.arizona.edu

Publikováno v: PLoS ONE. Feb2014, Vol. 9 Issue 2, p1-11. 11p.

Neuroprotective and Anti-inflammatory Effect of Tangeretin Against Cerebral Ischemia-Reperfusion Injury in Rats.

Autor: Yang T; First Affiliated Hospital, Heilongjiang University of Chinese Medicine, No. 26 Heping Road, Xiangfang District, Harbin, 150036, China.; Heilongjiang University of Chinese Medicine, No. 24 HepingRoad, Xiangfang District, Harbin, 150036, China., Feng C; First Affiliated Hospital, Heilongjiang University of Chinese Medicine, No. 26 Heping Road, Xiangfang District, Harbin, 150036, China.; Heilongjiang University of Chinese Medicine, No. 24 HepingRoad, Xiangfang District, Harbin, 150036, China., Wang D; Heilongjiang University of Chinese Medicine, No. 24 HepingRoad, Xiangfang District, Harbin, 150036, China., Qu Y; Heilongjiang University of Chinese Medicine, No. 24 HepingRoad, Xiangfang District, Harbin, 150036, China., Yang Y; Heilongjiang University of Chinese Medicine, No. 24 HepingRoad, Xiangfang District, Harbin, 150036, China., Wang Y; Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, No. 411 Guogeli Street, Nangang District, Harbin, 150000, China., Sun Z; Heilongjiang University of Chinese Medicine, No. 24 HepingRoad, Xiangfang District, Harbin, 150036, China. szr1960@sina.com.

Publikováno v: Inflammation [Inflammation] 2020 Dec; Vol. 43 (6), pp. 2332-2343.