Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kristin M Bedard"'
Autor:
Ikenna G Madu, Megan Files, Dima N Gharaibeh, Amy L Moore, Kie-Hoon Jung, Brian B Gowen, Dongcheng Dai, Kevin F Jones, Shanthakumar R Tyavanagimatt, James R Burgeson, Marcus J Korth, Kristin M Bedard, Shawn P Iadonato, Sean M Amberg
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007439 (2018)
Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular generates high morbidity and mortality in West Africa, where the disease is endemic, and a r
Externí odkaz:
https://doaj.org/article/158943d5f7714c32981e426acdf08c68
Autor:
Sean M. Amberg, Benjamin Snyder, Portia A. Vliet-Gregg, Eric J. Tarcha, Jeff Posakony, Kristin M. Bedard, Alison E. Heald
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
LHF-535 is a small-molecule antiviral currently under development as a therapeutic option to treat Lassa fever and other viral hemorrhagic fevers of arenavirus origin. The human safety and pharmacokinetics of LHF-535 were evaluated in two phase 1 tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee70a7e7dc7162fe40f9eee48141621
https://doi.org/10.1128/aac.00951-22
https://doi.org/10.1128/aac.00951-22
Autor:
Kathleen A. Cashman, Eric R. Wilkinson, Jeffrey Posakony, Ikenna G. Madu, Eric J. Tarcha, Kurt H. Lustig, Marcus J. Korth, Kristin M. Bedard, Sean M. Amberg
Publikováno v:
Scientific reports. 12(1)
LHF-535 is a small molecule antiviral currently in development for the treatment of Lassa fever, a zoonotic disease endemic in West Africa that generates significant morbidity and mortality. Current treatment options are inadequate, and there are no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24374c75ec17e0a01884cf45598eb0a2
https://pubmed.ncbi.nlm.nih.gov/36402782
https://pubmed.ncbi.nlm.nih.gov/36402782
Autor:
Yueh-Ming Loo, Courtney R. Wilkins, Sowmya Pattabhi, Megan L. Knoll, Shari Kaiser, Chad E. Mire, John Grigg, Emily A Hemann, Peter Probst, Jeffrey Posakony, Renee C. Ireton, Thomas W. Geisbert, Kristin M. Bedard, Shawn P. Iadonato, Michael Gale
Publikováno v:
The Journal of Immunology. 196:76.3-76.3
Retinoic acid inducible gene I (RIG-I) is essential for directing and priming the host immune response against many RNA viruses. A diverse small molecule library was used in a cell-based screening approach to identify drug-like compounds that could t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e508bf98b1310c6ae7eb91f2976f12a
https://doi.org/10.4049/jimmunol.196.supp.76.3
https://doi.org/10.4049/jimmunol.196.supp.76.3
Autor:
Peter Probst, John B Grigg, Emily A Hemann, Yueh-Ming Loo, Megan L Knoll, Renee Ireton, Michael J Gale, Shawn P Iadonato, Kristin M Bedard
Publikováno v:
The Journal of Immunology. 196:76.2-76.2
We have identified a panel of small molecule immunomodulators that activate IRF3 and induce innate immune signaling to drive an antigen-specific protective immune response against viral infections. Our lead adjuvant candidate, KIN1148, binds to retin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cae9a15ebf8b84c8b06c9775be48a9bd
https://doi.org/10.4049/jimmunol.196.supp.76.2
https://doi.org/10.4049/jimmunol.196.supp.76.2
Publikováno v:
The EMBO journal. 26(2)
A significant number of viral and cellular mRNAs utilize cap-independent translation, employing mechanisms distinct from those of canonical translation initiation. Cap-independent translation requires noncanonical, cellular RNA-binding proteins; howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c13682210917f5767d5f9f3d0f1f5e
https://pubmed.ncbi.nlm.nih.gov/17183366
https://pubmed.ncbi.nlm.nih.gov/17183366
Publikováno v:
RNA (New York, N.Y.). 10(8)
The cellular protein, poly(rC) binding protein 2 (PCBP2), is known to function in picornavirus cap-independent translation. We have further examined the RNA binding properties and protein–protein interactions of PCBP2 necessary for translation. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7b7cf4e328d8ce35beb1fe3bebe22c
https://pubmed.ncbi.nlm.nih.gov/15247434
https://pubmed.ncbi.nlm.nih.gov/15247434
Autor:
Kristin M. Bedard, Bert L. Semler
Publikováno v:
Microbes and infection. 6(7)
Members of the Picornaviridae are positive- strand RNA viruses that cause a variety of human diseases such as poliomyelitis, the common cold, myocarditis, and hepatitis. Although the diseases caused by picornaviruses are diverse, the genome organizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4d49597963f2a7e1c1e49f126bd13f
https://pubmed.ncbi.nlm.nih.gov/15158778
https://pubmed.ncbi.nlm.nih.gov/15158778