Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kristin L. Rockwell"'
Autor:
Kristin L. Rockwell, Paula M. Loria, Yue-Ming Wang, Marie-Claire Peakman, Andrea D. Weston, Claire M. Steppan, Regis Doyonnas, Fabien Vincent
Publikováno v:
Cell Chemical Biology. 27:1332-1346
The promise of phenotypic screening resides in its track record of novel biology and first-in-class therapies. However, challenges stemming from major differences between target-based and phenotypic screening do exist. These challenges prompted us to
Autor:
Kathryn E. Livingston, Lauren Budenholzer, Yi Shang, Abigail M. Fenton, John R. Traynor, Samuel Gerritz, Paola Bisignano, Marta Filizola, Kristin L. Rockwell, Neil T. Burford, Andrew Alt, Brennica Marlow
Publikováno v:
Journal of Chemical Information and Modeling. 55:1836-1843
With the hope of discovering effective analgesics with fewer side effects, attention has recently shifted to allosteric modulators of the opioid receptors. In the past two years, the first chemotypes of positive or silent allosteric modulators (PAMs
Autor:
Kristin L. Rockwell, Andrew Alt
Publikováno v:
Allosterism in Drug Discovery ISBN: 9781782624592
Activation of opioid receptors produces powerful analgesia; and µ-opioid receptor agonists such as morphine and oxycodone remain the “gold standard” for pain therapy, despite their abuse liability and dangerous side effect profile. Safer pain me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff1926f5697a5e3af5a83f208c249f63
https://doi.org/10.1039/9781782629276-00194
https://doi.org/10.1039/9781782629276-00194
Autor:
Kathrine Loomis, Kristin L. Rockwell, Meihua Tu, Paul A. Amor, Kirk McPherson, William P. Esler, Tereece Banks, Aaron C. Smith, Shawn Cabral, James J. Valentine, Susan Tapley, Kristen Ford, Colin R. Rose, Mark Niosi, Felix Vajdos, Carmen N. Garcia-Irizarry, Shawn D. Doran, James A. Southers, Scott W. Bagley, Margaret S. Landis, Alan M. Mathiowetz, Daniel W. Kung, David A. Griffith
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(22)
A novel series of spirocyclic-diamine based, isoform non-selective inhibitors of acetyl-CoA carboxylase (ACC) is described. These spirodiamine derivatives were discovered by design of a library to mimic the structural rigidity and hydrogen-bonding pa
Autor:
John J. Herbst, Meredith Ferrante, Annapurna Pendri, Kristin L. Rockwell, Jonathan O’Connell, Susan Jenkins, James Loy, Chi Shing Sum, Adam Hendricson, Martyn Banks, Robert G. Gentles, Yulia Benitex, Robert L. Bertekap, Neil T. Burford, Mary Ellen Cvijic, John E. Macor, Andrew Alt, Litao Zhang, Ryan Westphal, Jing Chen, Michelle Nophsker, Guo Li
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 356(2)
The muscarinic acetylcholine receptor subtype 1 (M1) receptors play an important role in cognition and memory, and are considered to be attractive targets for the development of novel medications to treat cognitive impairments seen in schizophrenia a
Autor:
Michael R. Weed, Jeffrey M. Brown, Brett R. Beno, Ryan S. Westphal, Robert G. Gentles, John Watson, Yan Kong, Lisa Hunihan, Martin A. Lewis, Mary Ellen Cvijic, John E. Macor, Joanne J. Bronson, Meredith Ferrante, Thaddeus F. Molski, Ronald J. Knox, Andrew Alt, Angela Cacace, Kristin L. Rockwell, Shuanghua Hu, Adam Hendricson, Yazhong Huang
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 354(3)
The present studies represent the first published report of a dopamine D1 positive allosteric modulator (PAM). D1 receptors have been proposed as a therapeutic target for the treatment of cognitive deficits associated with schizophrenia. However, the