Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kristin L. Leskoske"'
Autor:
Françoise M. Roelants, Kristin L. Leskoske, Maria Nieves Martinez Marshall, Melissa N. Locke, Jeremy Thorner
Publikováno v:
Biomolecules, Vol 7, Iss 3, p 66 (2017)
To grow, eukaryotic cells must expand by inserting glycerolipids, sphingolipids, sterols, and proteins into their plasma membrane, and maintain the proper levels and bilayer distribution. A fungal cell must coordinate growth with enlargement of its c
Externí odkaz:
https://doaj.org/article/8ccb22eaeb0f4c13a0c291caa49db723
Autor:
Kristin L. Leskoske, Krystine Garcia-Mansfield, Ritin Sharma, Aparna Krishnan, Jessica M. Rusert, Jill P. Mesirov, Robert J. Wechsler-Reya, Patrick Pirrotte
Publikováno v:
Journal of Proteome Research. 21:2124-2136
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. MB is classified into four primary molecular subgroups: wingless (WNT), sonic hedgehog (SHH), Group 3 (G3), and Group 4 (G4), and further genomic and proteomic subtypes have bee
Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress
Publikováno v:
eLife, Vol 4 (2015)
In eukaryotes, exposure to hypertonic conditions activates a MAPK (Hog1 in Saccharomyces cerevisiae and ortholog p38 in human cells). In yeast, intracellular glycerol accumulates to counterbalance the high external osmolarity. To prevent glycerol eff
Externí odkaz:
https://doaj.org/article/482db70761b04231aedbb002e3f1c59d
Autor:
Maria Nieves Martinez Marshall, Jeremy Thorner, Anita Emmerstorfer-Augustin, Lydia H. Zhang, Kristin L. Leskoske, Biyun Li
Publikováno v:
Molecular Biology of the Cell
Mol Biol Cell
Mol Biol Cell
Eukaryotic cell survival requires maintenance of plasma membrane (PM) homeostasis in response to environmental insults and changes in lipid metabolism. In yeast, a key regulator of PM homeostasis is target of rapamycin (TOR) complex 2 (TORC2), a mult
Autor:
Kristin L. Leskoske, Sara A. Byron, Seema Plaisier, Apurva M. Hegde, Krystine Garcia-Mansfield, Ritin Sharma, Genevieve Bergendahl, Abhinav Nagulapally, William Ferguson, Jaqueline Kraveka, Javier Oesterheld, William P. Hendricks, Giselle L. Saulnier Sholler, Jeffrey M. Trent, Patrick Pirrotte
Publikováno v:
Cancer Research. 82:2013-2013
Neuroblastoma is the most common solid extracranial tumor in children. Despite intensive multi-modal therapy, 5-year survival rates for patients with high-risk disease remain at approximately 50%. Neuroblastomas typically have low mutational burden a
Autor:
Edward P. Si, Jennifer M. Hill, Jeremy Thorner, Kristin L. Leskoske, Françoise M. Roelants, Christoph M. Augustin, Anita Emmerstorfer-Augustin
Publikováno v:
Genes & Development
Saccharomyces cerevisiae target of rapamycin (TOR) complex 2 (TORC2) is an essential regulator of plasma membrane lipid and protein homeostasis. How TORC2 activity is modulated in response to changes in the status of the cell envelope is unclear. Her
Autor:
Audrey Turchick, Yura Bandera, Steven D. Goodson, Michael G. Sehorn, Erin Ratterman, Lesly A. Temesvari, Alexander V. Mazin, Andrew A. Kelso, Stephen H. Foulger, Kristin L. Leskoske, LeAnna L. Ledford, Christopher C. Attaway, Suchitra Chavan, Amanda F. Say, Ada V. King, Deepti Sharma
Publikováno v:
Molecular and Biochemical Parasitology. 210:71-84
The protozoan parasite responsible for human amoebiasis is Entamoeba histolytica. An important facet of the life cycle of E. histolytica involves the conversion of the mature trophozoite to a cyst. This transition is thought to involve homologous rec
Autor:
Françoise M. Roelants, Anita Emmerstorfer-Augustin, Kristin L. Leskoske, Maria Nieves Martinez Marshall, Jeremy Thorner, Melissa N. Locke
Author(s): Thorner, Jeremy; Locke, Melissa N; Marshall, Maria Nieves Martinez; Emmerstorfer-Augustin, Anita; Leskoske, Kristin L; Roelants, Francoise M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890228005414d7c2856faebbfe250d57
https://escholarship.org/uc/item/0qw704b8
https://escholarship.org/uc/item/0qw704b8
Autor:
Ross T.A. Pedersen, Jeffrey Liu, Kristin L. Leskoske, Jeremy Thorner, Françoise M. Roelants, Gregory C. Finnigan, Alexander Muir
Publikováno v:
Molecular and cellular biology, vol 37, iss 7
Roelants, FM; Leskoske, KL; Pedersen, RTA; Muir, A; Liu, JMH; Finnigan, GC; et al.(2017). TOR complex 2-regulated protein kinase Fpk1 stimulates endocytosis via inhibition of Ark1/Prk1-related protein kinase Akl1 in Saccharomyces cerevisiae. Molecular and Cellular Biology, 37(7). doi: 10.1128/MCB.00627-16. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/5422n6bh
Molecular and Cellular Biology
Roelants, FM; Leskoske, KL; Pedersen, RTA; Muir, A; Liu, JMH; Finnigan, GC; et al.(2017). TOR complex 2-regulated protein kinase Fpk1 stimulates endocytosis via inhibition of Ark1/Prk1-related protein kinase Akl1 in Saccharomyces cerevisiae. Molecular and Cellular Biology, 37(7). doi: 10.1128/MCB.00627-16. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/5422n6bh
Molecular and Cellular Biology
© 2017 Roelants et al. Depending on the stress, plasma membrane alterations activate or inhibit yeast target of rapamycin (TOR) complex 2, which, in turn, upregulates or downregulates the activity of its essential downstream effector, protein kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78367d2189990f2c82cc0586c5d1ac74
https://escholarship.org/uc/item/5422n6bh
https://escholarship.org/uc/item/5422n6bh
Autor:
Jennifer M. Hill, Maria Nieves Martinez Marshall, Kristin L. Leskoske, Jeremy Thorner, Françoise M. Roelants
Publikováno v:
Leskoske, KL; Roelants, FM; Marshall, MNM; Hill, JM; & Thorner, J. (2017). The stress-sensing TORC2 complex activates yeast AGC-family protein kinase ypk1 at multiple novel sites. Genetics, 207(1), 179-195. doi: 10.1534/genetics.117.1124. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/62k6m4j2
Genetics, vol 207, iss 1
Genetics
Genetics, vol 207, iss 1
Genetics
Yeast (Saccharomyces cerevisiae) target of rapamycin (TOR) complex 2 (TORC2) is a multi-subunit plasma membrane-associated protein kinase and vital growth regulator. Its essential functions are exerted via phosphorylation and stimulation of downstrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799788ac439e924340db9d9d9fd252b0
http://www.escholarship.org/uc/item/62k6m4j2
http://www.escholarship.org/uc/item/62k6m4j2