Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kristin L. Horton"'
Autor:
Dong Wei, Kristin L. Horton, John Chen, Linlin Dong, Susan Chen, Kojo Abdul-Hadi, Ting Ting Zhang, Cierra N. Casson, Michael Shaw, Tsubasa Shiraishi, Brandon Wilkinson, Chengjie Ji, Mark G. Qian
Publikováno v:
Molecules, Vol 28, Iss 8, p 3311 (2023)
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a check point protein expressed on the surface of T cells and plays a central role in regulating the immune response. In recent years, CTLA-4 has become a popular target for cancer immunotherapy
Externí odkaz:
https://doaj.org/article/98acaeab752f445abc9736539115085f
Autor:
John K. Scott, Simon J. McKirdy, Johann van der Merwe, Roy Green, Andrew A. Burbidge, Greg Pickles, Darryl C. Hardie, Keith Morris, Peter G. Kendrick, Melissa L. Thomas, Kristin L. Horton, Simon M. O’Connor, Justin Downs, Richard Stoklosa, Russell Lagdon, Barbara Marks, Malcolm Nairn, Kerrie Mengersen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Barrow Island, north-west coast of Australia, is one of the world’s significant conservation areas, harboring marsupials that have become extinct or threatened on mainland Australia as well as a rich diversity of plants and animals, some e
Externí odkaz:
https://doaj.org/article/323b1f5e521e4316989effb8505de52e
Autor:
Simon O’Connor, Simon McKirdy, Kristin L. Horton, Johann van der Merwe, Melissa L. Thomas, Angus Williams, Nihara Gunawardene
Publikováno v:
Biological Invasions. 19:2751-2765
Early detection of target non-indigenous species is one of the most important determinants of a successful eradication campaign. For early detection to be successful, and provide the highest probability of achieving eradication, intense surveillance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b4e897556ed0c64e6655093a2c3ace5
https://doi.org/10.1007/s10530-017-1481-6
https://doi.org/10.1007/s10530-017-1481-6
Autor:
Melissa L. Thomas, Simon O’Connor, Grey T. Coupland, Darryl Hardie, Johann van der Merwe, Simon McKirdy, Kristin L. Horton, Angus Williams
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Large sea-going passenger vessels can pose a high biosecurity risk. The risk posed by marine species is well documented, but rarely the risk posed by terrestrial arthropods. We conducted the longest running, most extensive monitoring program of terre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41f78f2edf6369da71a620b3aac056f
https://doi.org/10.1038/s41598-019-55554-4
https://doi.org/10.1038/s41598-019-55554-4
Autor:
Simon O’Connor, Peter G. Kendrick, Greg Pickles, Melissa L. Thomas, Barbara Marks, John K. Scott, Simon McKirdy, Roy Green, Darryl Hardie, Justin Downs, Kristin L. Horton, Andrew A. Burbidge, Malcolm Nairn, Keith Morris, Johann van der Merwe, Richard Stoklosa, Russell Lagdon, Kerrie Mengersen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Barrow Island, north-west coast of Australia, is one of the world’s significant conservation areas, harboring marsupials that have become extinct or threatened on mainland Australia as well as a rich diversity of plants and animals, some endemic. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c63882b2404715fa4339d0cc4a42966
Publikováno v:
ChemBioChem. 13:476-485
Mitochondrially targeted agents have the capacity to be both vehicles for the delivery of bioactive agents and mitochondrial disrupters and show promise for the treatment of various diseases. Engineering these agents to specifically accumulate or dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09171f7d2b060c1e5ac16f9aca0b9c95
https://doi.org/10.1002/cbic.201100415
https://doi.org/10.1002/cbic.201100415
Autor:
Sonali B. Fonseca, Rose Hurren, Mark P. Pereira, Kristin L. Horton, Shana O. Kelley, Marcela Gronda, Rida Mourtada, Aaron D. Schimmer, Mark D. Minden
Publikováno v:
Chemistrybiology. 18(4)
SummaryThe difficulty of accessing the mitochondrial matrix has limited the targeting of therapeutics to this organelle. Here, we report, to our knowledge, the first successful delivery of an active DNA alkylating agent—chlorambucil—to mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2dd9a130a800170834ac4e69f3a27a
https://pubmed.ncbi.nlm.nih.gov/21513881
https://pubmed.ncbi.nlm.nih.gov/21513881
Publikováno v:
Chembiochem : a European journal of chemical biology. 10(12)
A class of mitochondria-penetrating peptides (MPPs) was studied in an effort to optimize their applications in the delivery of bioactive cargo to this therapeutically important organelle. The sequence requirements for mitochondrial entry were monitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7167484fbe1bef234d1053037f13bf5c
https://pubmed.ncbi.nlm.nih.gov/19670199
https://pubmed.ncbi.nlm.nih.gov/19670199
Autor:
Kristin L. Horton, Shana O. Kelley
Publikováno v:
Journal of medicinal chemistry. 52(10)
Apoptosis-inducing peptides that trigger mitochondrial disruption are a popular tool in pharmaceutical and anticancer research. While useful, their potencies are low, which impedes further development of drugs based on these sequences. Here, we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc84cbfb64e251462cc21149e73add23
https://pubmed.ncbi.nlm.nih.gov/19397319
https://pubmed.ncbi.nlm.nih.gov/19397319
Publikováno v:
ChemInform. 39
Cell-penetrating peptides (CPPs) have found numerous applications in biology and medicine since the first synthetic cell-permeable sequence was identified two decades ago. Numerous types of drugs have been transported into cells using CPPs, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be8d3975c445d824aa3b88b905a2e862
https://doi.org/10.1002/chin.200841265
https://doi.org/10.1002/chin.200841265