Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Kristin L. Granlund"'
1
Improved total sensitivity estimation for multiple receive coils in MRI using ratios of first-order statistics
Autor: Vesselin Z. Miloushev, Rostislav Boltyanskiy, Kristin L. Granlund, Kayvan R. Keshari
Publikováno v: Magnetic Resonance Materials in Physics, Biology and Medicine. 35:895-901
Spatial variation in the sensitivity profiles of receive coils in MRI leads to spatially dependent scaling of the signal amplitude across an image. In practice, total sensitivity of the coil array is either calibrated or corrected directly by compari
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca60be006bdf3ad5cb210fc41d51bb2a
https://doi.org/10.1007/s10334-022-01028-0
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4
Hyperpolarized [5- 13 C,4,4- 2 H 2 ,5- 15 N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine
Autor: Roozbeh Eskandari, Nathaniel Kim, Arsen Mamakhanyan, Michelle Saoi, Guannan Zhang, Marjan Berishaj, Kristin L. Granlund, Alex J. Poot, Justin Cross, Craig B. Thompson, Kayvan R. Keshari
Publikováno v: Proceedings of the National Academy of Sciences. 119
Significance Glutamine is the most abundant amino acid in human plasma, although it is challenging to determine glutamine’s metabolic fate noninvasively. In this work, we utilize established chemical methods to develop a platform for imaging glutam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::247dec701a3b5421a7577112bb239e9d
https://doi.org/10.1073/pnas.2120595119
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5
Hyperpolarized [5
Autor: Roozbeh, Eskandari, Nathaniel, Kim, Arsen, Mamakhanyan, Michelle, Saoi, Guannan, Zhang, Marjan, Berisaj, Kristin L, Granlund, Alex J, Poot, Justin, Cross, Craig B, Thompson, Kayvan R, Keshari
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(19)
Glutamine is consumed by rapidly proliferating cells and can provide the carbon and nitrogen required for growth through various metabolic pathways. However, delineating the metabolic fate of glutamine is challenging to interrogate in vivo. Hyperpola
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b972215dd26f2abc1413f9dc96dfc62
https://pubmed.ncbi.nlm.nih.gov/35512101
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6
Dynamic volumetric hyperpolarized 13 C imaging with multi‐echo EPI
Autor: Arsen Mamakhanyan, Nathaniel Kim, Kayvan R. Keshari, Roozbeh Eskandari, Kristin L. Granlund, Kofi Deh
Publikováno v: Magnetic Resonance in Medicine. 85:978-986
PURPOSE To generate dynamic, volumetric maps of hyperpolarized [1-13 C]pyruvate and its metabolic products in vivo. METHODS Maps of chemical species were generated with iterative least squares (IDEAL) reconstruction from multiecho echo-planar imaging
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3d1ea1b966042e83b44efab7fb69bdd
https://doi.org/10.1002/mrm.28466
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7
Hyperpolarized [6-13C,15N3]-Arginine as a Probe for in Vivo Arginase Activity
Autor: Roozbeh Eskandari, Kayvan R. Keshari, Kristin L. Granlund, Andrew Cho
Publikováno v: ACS Chemical Biology. 14:665-673
Alterations in arginase enzyme expression are linked with various diseases and have been shown to support disease progression, thus motivating the development of an imaging probe for this enzymatic target. 13C-enriched arginine can be used as a hyper
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a05a4fa09146a28b09a2bbf7624f4e3c
https://doi.org/10.1021/acschembio.8b01044
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8
Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models
Autor: Chelsea E. Ray, Kayvan R. Keshari, Sangmoo Jeong, Sui Seng Tee, Yiyu Dong, Vesselin Z. Miloushev, Ying-Bei Chen, Kristin L. Granlund, Roozbeh Eskandari, Omer Aras, Emily H. Cheng, James J. Hsieh, Lidia Dos Santos-Cunha
Publikováno v: Cancer Research. 79:242-250
The ever-changing tumor microenvironment constantly challenges individual cancer cells to balance supply and demand, presenting tumor vulnerabilities and therapeutic opportunities. Everolimus and temsirolimus are inhibitors of mTOR (mTORi) approved f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24daf4b5f405c2656c7e5d94b4aa0df1
https://doi.org/10.1158/0008-5472.can-18-2231
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9
Multi-sample measurement of hyperpolarized pyruvate-to-lactate flux in melanoma cells
Autor: Kristin L. Granlund, Fayyaz Ahamed, Micaela Millan, Roozbeh Eskandari, Kayvan R. Keshari, Sangmoo Jeong, Hannah Lees
Publikováno v: NMR Biomed
Hyperpolarized [1-(13)C] pyruvate can be used to examine the metabolic state of cancer cells, highlighting a key metabolic characteristic of cancer: the upregulated metabolic flux to lactate, even in the presence of oxygen (Warburg effect). Thus, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d07987ac52691af3410198521b96a6f
https://europepmc.org/articles/PMC8288443/
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10
Dynamic volumetric hyperpolarized
Autor: Kofi, Deh, Kristin L, Granlund, Roozbeh, Eskandari, Nathaniel, Kim, Arsen, Mamakhanyan, Kayvan R, Keshari
Publikováno v: Magn Reson Med
PURPOSE: To generate dynamic, volumetric maps of hyperpolarized [1-(13)C]pyruvate and its metabolic products in vivo. METHODS: Maps of chemical species were generated with iterative least squares (IDEAL) reconstruction from multiecho echo-planar imag
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::427f149bd5f5f0f9ce1097e5e663e049
https://pubmed.ncbi.nlm.nih.gov/32820566
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