Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kristin Klepper"'
Autor:
Jason P. Caffrey, Jason W. Adams, Isabel Costantino, Kristin Klepper, Elina Kari, Lori A. Brown
Publikováno v:
Journal of Medical Case Reports, Vol 14, Iss 1, Pp 1-4 (2020)
Abstract Background Facial baroparesis is a palsy of the seventh cranial nerve resulting from increased pressure compressing the nerve along its course through the middle ear cavity. It is a rare condition, most commonly reported in barotraumatic env
Externí odkaz:
https://doaj.org/article/eb25f40a69954ac78fbc62839841b868
Autor:
Daniel Tannous, Kristin Klepper
Publikováno v:
Perm J
INTRODUCTION: With the number of COVID cases in children increasing, the variation in presentation seen in pediatric patients compared with adults has become more apparent. The typical adult presentation of COVID-19 infection, generally associated wi
Publikováno v:
Journal of Neuroscience Research. 98:1685-1697
The pathophysiology of age-related hearing loss (ARHL), or presbycusis, involves a complex interplay between environmental and genetic factors. The fundamental biomolecular mechanisms of ARHL have been well described, including the roles of membrane
Autor:
Sarah B. Stringfield, Samuel Eisenstein, Sonia Ramamoorthy, Nicole E. Lopez, Lisa Parry, Benjamin Abbadessa, Kristin Klepper, Hannah M. Hollandsworth, Beiqun Zhao
Publikováno v:
Surg Endosc
Surgical endoscopy, vol 34, iss 11
Surgical endoscopy, vol 34, iss 11
BackgroundCommon colorectal procedures that require access to all quadrants of the abdomen are subtotal colectomy (STC) and total proctocolectomy (TPC). These are frequently performed with a surgical robot, but multiquadrant operations have unique ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0146129582118fe874eca91acbe57e61
https://europepmc.org/articles/PMC10201451/
https://europepmc.org/articles/PMC10201451/
Autor:
Trey Ideker, Jason F. Kreisberg, Kyle S. Sanchez, Alex Thomas, Kristin Klepper, John Paul Shen, Katherine Licon, Daniel Pekin, Nevan J. Krogan, Amanda Birmingham, Prashant Mali, Chih-Chung Kuo, Assen Roguev, Nathan E. Lewis, Aaron N. Chang, Lei S. Qi, Ana Bojorquez-Gomez, Dan Du, Roman Sasik, Jens Luebeck, Alex Beckett, Dongxin Zhao
Publikováno v:
Nature methods, vol 14, iss 6
Nature methods
Nature methods
We developed a systematic approach to map human genetic networks by combinatorial CRISPR-Cas9 perturbations coupled to robust analysis of growth kinetics. We targeted all pairs of 73 cancer genes with dual-guide RNAs in three cell lines, altogether c
Autor:
Jason P. Caffrey, Kristin Klepper, Isabel Costantino, Jason W. Adams, Elina Kari, Lori A. Brown
Publikováno v:
Journal of Medical Case Reports
Journal of Medical Case Reports, Vol 14, Iss 1, Pp 1-4 (2020)
Journal of Medical Case Reports, Vol 14, Iss 1, Pp 1-4 (2020)
Background Facial baroparesis is a palsy of the seventh cranial nerve resulting from increased pressure compressing the nerve along its course through the middle ear cavity. It is a rare condition, most commonly reported in barotraumatic environments
Autor:
Katherine Licon, John Paul Shen, Ana Bojorquez-Gomez, Andrew M. Gross, Chu Ping Qiu, Huwate Yeerna, Jia L. Xu, Rohith Srivas, Haico van Attikum, Robert W. Sobol, Vignesh Sivaganesh, Su Ming Sun, Eric J. Jaehnig, Daniel Pekin, Jianfeng Li, Kristin Klepper, Trey Ideker
Publikováno v:
Oncotarget
Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular biomarkers to identify specific patients most likely to respond to therapy. To this end, we
Autor:
Robert W. Sobol, Justin K. Huang, Trey Ideker, Jianfeng Li, Jia L. Xu, Ana Bojorquez-Gomez, Andrew M. Gross, James Jensen, Leonie Kollenstart, Rohith Srivas, Daniel Pekin, John Paul Shen, Haico van Attikum, Kristin Klepper, Vignesh Sivaganesh, Chih Cheng Yang, Su Ming Sun, Pedro Aza-Blanc, Huwate Yeerna, Katherine Licon
Publikováno v:
Molecular Cell, 63(3), 514-525
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here we use a multi-species approach to develop a resource of synthetic lethal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8619741cd89b289b24df77a20c39353
https://hdl.handle.net/1887/113262
https://hdl.handle.net/1887/113262
Autor:
Trey Ideker, Kyle S. Sanchez, Roman Sasik, Kristin Klepper, Katherine Licon, Alex Beckett, Ana Bojorquez-Gomez, Dongxin Zhao, John Paul Shen, Brenton Munson, Prashant Mali, Amanda Birmingham
Publikováno v:
Cancer Research. 78:3299-3299
Genetic interactions, in particular negative or "synthetic-lethal" interactions for which simultaneous disruption of two genes causes cell killing, have implications for therapeutic development as has been demonstrated by the clinical success of PARP
Autor:
John Paul Shen, Trey Ideker, Matan Hofree, Alex Beckett, Ana Bojorquez-Gomez, Kristin Klepper, Jason F. Kreisberg, Cheryl C. Saenz, Justin K. Huang
Publikováno v:
Clinical Cancer Research. 23:AP23-AP23
PURPOSE: Like many solid tumors, high grade serous ovarian carcinoma (HGSOC) is a heterogeneous entity with a widely variable clinical course even among patients of the same stage and histological subtype. Although most patients will achieve remissio