Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kristin Kee"'
Autor:
Salim Merali, Barbara A. Foster, Slavoljub Vujcic, Debora L. Kramer, Mary L. Hensen, Carl W. Porter, Kristin Kee, Richard Mazurchuk, Paula Diegelman, Nicholas Kisiel
Publikováno v:
Journal of Biological Chemistry. 279:40076-40083
The enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) regulates the catabolism and export of intracellular polyamines. We have previously shown that activation of polyamine catabolism by conditional overexpression of SSAT has antiproliferative
Autor:
Kristin Kee, Peter Kanter, Jean M. Veith, Fernando Cabral, William R. Greco, Amarnath Sharma, Iwao Ojima, Michael R. Vredenburg, Paula Pera, Ralph J. Bernacki
Publikováno v:
JNCI Journal of the National Cancer Institute. 93:1234-1245
Background: The taxane paclitaxel (Taxol) is often of limited efficacy in chemotherapeutic regimens because some cancer cells express high levels of the efflux pump, P-glycoprotein (Pgp), which removes the drug from the cells. The orally active pacli
Publikováno v:
Proceedings of the National Academy of Sciences. 95:5205-5210
beta-chemokines play an important role in the development of immunologic reactions. Macrophages are major beta-chemokine-producing cells during T-cell directed, delayed-type hypersensitivity reactions in tissues, and have been reported to be importan
Autor:
Kristin Kee, Jeffrey E. Green
Publikováno v:
Cancer Drug Discovery and Development ISBN: 9781588295309
Since the declaration of the qwar on cancerq three decades ago, an improved understanding of molecular mechanisms behind malignant disease has led to the discovery of novel targets for cancer therapy. Despite such great efforts, many compounds that h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f3d550081a6c34ef6900a2846158411
https://doi.org/10.1007/978-1-59745-035-5_30
https://doi.org/10.1007/978-1-59745-035-5_30
Autor:
Kristin Kee, Geoffrey W. Stone, Victoria Snarsky, Xiao Fang Yu, Suzanne Barzee, Richard S. Kornbluth, Celsa A. Spina
For use in humans, human immunodeficiency virus (HIV) DNA vaccines may need to include immunostimulatory adjuvant molecules. CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) superfamily (TNFSF), is one candidate adjuvant, but it has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce5c1077968056bf999e00df6226185
https://europepmc.org/articles/PMC1367159/
https://europepmc.org/articles/PMC1367159/
Autor:
Paula Diegelman, Slavoljub Vujcic, Nicholas Kisiel, Debora L. Kramer, C. Thomas Powell, Carl W. Porter, Salim Merali, Kristin Kee
Publikováno v:
The Journal of biological chemistry. 279(26)
Depletion of intracellular polyamine pools invariably inhibits cell growth. Although this is usually accomplished by inhibiting polyamine biosynthesis, we reasoned that this might be more effectively achieved by activation of polyamine catabolism at
Autor:
Ying, Chen, Kersti, Alm, Slavoljub, Vujcic, Debora L, Kramer, Kristin, Kee, Paula, Diegelman, Carl W, Porter
Publikováno v:
Cancer research. 63(13)
The clinically relevant polyamine analogue N(1),N(11)-diethylnorspermine (DENSPM) inhibits cell growth by down-regulating polyamine biosynthesis, up-regulating polyamine catabolism at the level of spermidine/spermine N(1)-acetyltransferase (SSAT), an