Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Kristin J Hope"'
Publikováno v:
HemaSphere, Vol 8, Iss 8, Pp n/a-n/a (2024)
Abstract Strict control over hematopoietic stem cell decision making is essential for healthy life‐long blood production and underpins the origins of hematopoietic diseases. Acute myeloid leukemia (AML) in particular is a devastating hematopoietic
Externí odkaz:
https://doaj.org/article/bf6d0938780a4c0ab6b271858aea0e8d
Autor:
Lina Liu, Ana Vujovic, Nandan P. Deshpande, Shashank Sathe, Govardhan Anande, He Tian Tony Chen, Joshua Xu, Mark D. Minden, Gene W. Yeo, Ashwin Unnikrishnan, Kristin J. Hope, Yu Lu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Leukemic stem cells (LSCs) drive chemoresistance and relapse in acute myeloid leukemia. Here, the authors show that the splicing factor RBM17 supports LSCs through avoiding nonsense-mediated decay of pro-leukaemic factors such as the translation init
Externí odkaz:
https://doaj.org/article/85c36ded2db34489ade4dbffb3dc816b
Autor:
Ana Vujovic, Laura de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian A. Yee, Sampath K. Loganathan, Lina Liu, Derek C.H. Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Zaldy Balde, Soheil Jahangiri, Sasan Zandi, Stefan Aigner, John E. Dick, Mark D. Minden, Daniel Schramek, Gene W. Yeo, Kristin J. Hope
Publikováno v:
Blood Cancer Discovery. 4:180-207
Acute myeloid leukemia (AML) is fueled by leukemic stem cells (LSC) whose determinants are challenging to discern from hematopoietic stem cells (HSC) or uncover by approaches focused on general cell properties. We have identified a set of RNA-binding
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100124- (2020)
Summary: Despite a surge in the preclinical development of immunotherapies, current models are unable to predict putative toxicity, particularly the “on-target, off-tumor” effects of these therapeutics. To address this gap, we used a humanized mo
Externí odkaz:
https://doaj.org/article/739c67f503184112b8019c3dbee72bab
Autor:
Muluken S. Belew, Sonam Bhatia, Ava Keyvani Chahi, Stefan Rentas, Jonathan S. Draper, Kristin J. Hope
Publikováno v:
Stem Cell Reports, Vol 10, Iss 4, Pp 1384-1397 (2018)
Summary: MSI2, which is expressed predominantly in hematopoietic stem and progenitor cells (HSPCs), enforces HSPC expansion when overexpressed and is upregulated in myeloid leukemias, indicating its regulated transcription is critical to balanced sel
Externí odkaz:
https://doaj.org/article/696a4f9d5be34658b2a9828b04d556c1
Autor:
Ava Keyvani Chahi, Muluken S. Belew, Joshua Xu, He Tian Tony Chen, Stefan Rentas, Veronique Voisin, Gabriela Krivdova, Eric Lechman, Sajid A. Marhon, Daniel D. De Carvalho, John E. Dick, Gary D. Bader, Kristin J. Hope
Publikováno v:
Blood. 140:992-1008
Hematopoietic stem cell (HSC) dormancy is understood as supportive of HSC function and its long-term integrity. Although regulation of stress responses incurred as a result of HSC activation is recognized as important in maintaining stem cell functio
Autor:
Kristin J. Hope, Gene W. Yeo, Daniel Schramek, Mark D. Minden, John E. Dick, Stefan Aigner, Sasan Zandi, Soheil Jahangiri, Zaldy Balde, Nicholas Wong, Joshua Xu, Pratik Joshi, Steven Moreira, Emily Tsao, Amanda Tajik, Derek C.H. Chan, Lina Liu, Sampath K. Loganathan, Brian A. Yee, He Tian Chen, Ava Keyvani Chahi, Laura de Rooij, Ana Vujovic
Table S5 shows the log2 fold change of differentially expressed transcripts from the ELAVL1 knockout RN2c RNA-sequencing data set.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238801bda66a9156f6af773fa36da1b5
https://doi.org/10.1158/2643-3230.22725570
https://doi.org/10.1158/2643-3230.22725570
Autor:
Kristin J. Hope, Gene W. Yeo, Daniel Schramek, Mark D. Minden, John E. Dick, Stefan Aigner, Sasan Zandi, Soheil Jahangiri, Zaldy Balde, Nicholas Wong, Joshua Xu, Pratik Joshi, Steven Moreira, Emily Tsao, Amanda Tajik, Derek C.H. Chan, Lina Liu, Sampath K. Loganathan, Brian A. Yee, He Tian Chen, Ava Keyvani Chahi, Laura de Rooij, Ana Vujovic
Supplemental Figure S4 shows the validation of ELAVL1 knockdown by western blot and effects of ELAVL1 loss on human primary AML cells in vitro and in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cb536bc316f972180d6869ba2df29c
https://doi.org/10.1158/2643-3230.22725594
https://doi.org/10.1158/2643-3230.22725594
Autor:
Kristin J. Hope, Gene W. Yeo, Daniel Schramek, Mark D. Minden, John E. Dick, Stefan Aigner, Sasan Zandi, Soheil Jahangiri, Zaldy Balde, Nicholas Wong, Joshua Xu, Pratik Joshi, Steven Moreira, Emily Tsao, Amanda Tajik, Derek C.H. Chan, Lina Liu, Sampath K. Loganathan, Brian A. Yee, He Tian Chen, Ava Keyvani Chahi, Laura de Rooij, Ana Vujovic
Acute myeloid leukemia (AML) is fueled by leukemic stem cells (LSC) whose determinants are challenging to discern from hematopoietic stem cells (HSC) or uncover by approaches focused on general cell properties. We have identified a set of RNA-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c408b73a88713bd19863989035bb281
https://doi.org/10.1158/2643-3230.c.6572000
https://doi.org/10.1158/2643-3230.c.6572000
Autor:
Vickie Kwan, Durga Praveen Meka, Sean H. White, Claudia L. Hung, Nicholas T. Holzapfel, Susan Walker, Nadeem Murtaza, Brianna K. Unda, Birgit Schwanke, Ryan K.C. Yuen, Kendra Habing, Chloe Milsom, Kristin J. Hope, Ray Truant, Stephen W. Scherer, Froylan Calderon de Anda, Karun K. Singh
Publikováno v:
Cell Reports, Vol 17, Iss 7, Pp 1892-1904 (2016)
The development of neural connectivity is essential for brain function, and disruption of this process is associated with autism spectrum disorders (ASDs). DIX domain containing 1 (DIXDC1) has previously been implicated in neurodevelopmental disorder
Externí odkaz:
https://doaj.org/article/3a5ecf5bb9b64b5cab80d85b37eba2ff