Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kristin H. Loomis"'
Autor:
Kristin H. Loomis, Susan K. Wu, Amanda Ernlund, Kristina Zudock, Allison Reno, Kianna Blount, David K. Karig
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Background Skin, the largest organ of the human body by weight, hosts a diversity of microorganisms that can influence health. The microbial residents of the skin are now appreciated for their roles in host immune interactions, wound healing
Externí odkaz:
https://doaj.org/article/d483ec74b87a4d68a4f02a4d471aa4f9
Autor:
Emmeline L. Blanchard, Kristin H. Loomis, Sushma M. Bhosle, Daryll Vanover, Patrick Baumhof, Bruno Pitard, Chiara Zurla, Philip J. Santangelo
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 52-66 (2019)
The characterization of innate immune activation is crucial for vaccine and therapeutic development, including RNA-based vaccines, a promising approach. Current measurement methods quantify type I interferon and inflammatory cytokine production, but
Externí odkaz:
https://doaj.org/article/ce9a7b51eb514c22a442138d2bda3bc5
Autor:
Kristina K Zudock, Allison Reno, Susan K. Wu, Amanda Ernlund, Kristin H. Loomis, Kianna M Blount, David K. Karig
Publikováno v:
Microbiome
Microbiome, Vol 9, Iss 1, Pp 1-17 (2021)
Microbiome, Vol 9, Iss 1, Pp 1-17 (2021)
Background Skin, the largest organ of the human body by weight, hosts a diversity of microorganisms that can influence health. The microbial residents of the skin are now appreciated for their roles in host immune interactions, wound healing, coloniz
Autor:
Philip J. Santangelo, Ravi V. Bellamkonda, Sushma M. Bhosle, Kristin H. Loomis, Jonathan L. Kirschman
Publikováno v:
Journal of materials chemistry. B. 4(9)
Synthetic mRNA has recently shown great potential as a tool for genetic introduction of proteins. Its utility as a gene carrier has been demonstrated in several studies for both the introduction of therapeutic proteins and subunit vaccines. At one po
Autor:
Kristin H. Loomis, Jonathan L. Kirschman, Kevin E. Lindsay, Philip J. Santangelo, Ravi V. Bellamkonda, Chiara Zurla, Daryll Vanover, Emmeline L. Blanchard, Sushma M. Bhosle
Publikováno v:
Bioconjugate Chemistry. 29:3072-3083
In vitro transcribed (IVT) mRNA is an appealing platform for next generation vaccines, as it can be manufactured rapidly at large scale to meet emerging pathogens. However, its performance as a robust vaccine is strengthened by supplemental immune st
Autor:
Sushma M. Bhosle, Philip J. Santangelo, Damien Habrant, Kristin H. Loomis, Jonathan L. Kirschman, Chiara Zurla, Daryll Vanover, Bruno Pitard, Patrick Baumhof, Emmeline L. Blanchard, Darin K. Edwards
Publikováno v:
Biomaterials. 159:189-203
The translational efficiency of an in vitro transcribed (IVT) mRNA was measured upon delivery to primary skeletal muscle cells and to a mouse model system, towards the development of a predictive in vitro assay for the screening and validation of int
Autor:
Tarun Saxena, Radhika Patkar, Ravi V. Bellamkonda, S. Balakrishna Pai, Eric Gaupp, Ketki Patil, Kristin H. Loomis, Lohitash Karumbaiah
Publikováno v:
ACS Nano. 9:1492-1505
Spinal cord injury (SCI) can lead to permanent motor and sensory deficits. Following the initial traumatic insult, secondary injury mechanisms characterized by persistent heightened inflammation are initiated and lead to continued and pervasive cell
Autor:
Kristin H. Loomis, Emmeline L. Blanchard, Jonathan L. Kirschman, Kathryn Murray, Philip J. Santangelo, Sushma M. Bhosle, Daryll Vanover, Blaine C Lam, Chiara Zurla
Publikováno v:
Nucleic Acids Research
The use of synthetic messenger ribonucleic acid (mRNA) to express specific proteins is a highly promising therapeutic and vaccine approach that avoids many safety issues associated with viral or DNA-based systems. However, in order to optimize mRNA d
Autor:
Ilya G. Lyakhov, Jacek Capala, Brandon T. Smith, Anu Puri, Kristin H. Loomis, Danielle Needle, Ulrich Baxa, Amichai Yavlovich, Robert Blumenthal
Publikováno v:
Journal of Controlled Release. 153:187-194
We previously reported the formulation and physical properties of HER2 (human epidermal growth factor receptor 2)-specific affibody (ZHER2:342-Cys) conjugated thermosensitive liposomes (HER2(+)affisomes). Here we examined localized delivery potential
Publikováno v:
Soft Matter. 7:839-856
The tendency for nanoparticles to accumulate in tumor regions as a result of the enhanced permeability and retention effect has proven to be an advantageous feature for delivery of anti-cancer therapeutics and contrast agents for cancer detection. Ho