Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kristin Grunz"'
Publikováno v:
Journal of Thrombosis and Haemostasis. 17:149-156
Essentials Protein Z (PZ) catalyzes PZ-dependent proteinase inhibitor (ZPI) inactivation of factor (F)Xa. Gene-deletion of PZ or ZPI improves coagulation in hemophilia (FVIII knockout) mice. A PZ blocking antibody enhances thrombin generation in huma
Autor:
Maki Kitano, Sven Danckwardt, Young K. Lee, T. Son Nguyen, Hartmut Weiler, Wolfram Ruf, Mona Saffarzadeh, Kristin Grunz, Carina D. S. Rodrigues, Sabine Reyda
Publikováno v:
Blood Adv
Deficiencies in many coagulation factors and protease-activated receptors (PARs) affect embryonic development. We describe a defect in definitive erythropoiesis in PAR2-deficient mice. Embryonic PAR2 deficiency increases embryonic death associated wi
Publikováno v:
Journal of Thrombosis and Haemostasis. 16:2246-2257
Essentials Mouse models are often used to define roles of tissue factor pathway inhibitor (TFPI) in man. TFPI isoform-specific KOs reveal unexpected differences between mouse and human TFPI physiology. Mouse plasma contains 20 times more TFPI than ma