Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kristin G Huwiler"'
Autor:
Marie K. Schwinn, Kristin G. Huwiler, Julie E. Pickett, Kilian Huber, Mei Cong, Thomas Machleidt, Morgan R. Ingold, Matthew B. Robers, Jennifer Wilkinson, Frank Fan, Cesear Corona, Carrow I. Wells, Domenic Ogno, Amy Landreman, Chad Zimprich, James D Vasta
Publikováno v:
Cancer Research. 80:5808-5808
Cyclin-dependent kinases (CDK) play key roles in diverse cellular functions including cell cycle control, cell proliferation, and transcriptional regulation. Due to these important roles, CDKs have been targeted for cancer therapeutic development, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b13306f7050bc5387b4248d6c8d5dd2
https://doi.org/10.1158/1538-7445.am2020-5808
https://doi.org/10.1158/1538-7445.am2020-5808
Autor:
Carina Glas, Kristin G. Huwiler, Thomas A. Kirkland, Kristopher Zimmerman, James D Vasta, Cesear Corona, Stefan Knapp, Chad Zimprich, Matthew B. Robers, Ke Ding, Paul Otto, Frank Fan, Susanne Müller, James Robert Hartnett, Thomas Machleidt, Benedict-Tilman Berger, Jennifer Wilkinson, Keith V. Wood, David H. Drewry, Poncho Meisenheimer, Kilian Huber, Carrow I. Wells, Mei Cong, Thomas Hanke, Morgan R. Ingold, Timothy M. Willson, Rachel Friedman Ohana, Michael R. Slater
Publikováno v:
Cell Chemical Biology
Summary For kinase inhibitors, intracellular target selectivity is fundamental to pharmacological mechanism. Although a number of acellular techniques have been developed to measure kinase binding or enzymatic inhibition, such approaches can fail to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc8d115cc6a4e1bbbbadcb2b8ee032a
https://doi.org/10.1016/j.chembiol.2017.10.010
https://doi.org/10.1016/j.chembiol.2017.10.010
Autor:
Morgan R. Ingold, James D Vasta, Matthew B. Robers, Cesear Corona, Kristin G Huwiler, Jennifer Wilkinson, Chad Zimprich
Publikováno v:
Genetic Engineering & Biotechnology News. 38:12-13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c3740bb2e58f3907adf61a9b864ce03
https://doi.org/10.1089/gen.38.02.06
https://doi.org/10.1089/gen.38.02.06
Publikováno v:
Biochemistry. 41:14329-14339
Thrombospondin-1 (TSP1), a modular secreted glycoprotein, possesses anti-angiogenic activity both in vitro and in vivo. This activity has been localized to the thrombospondin type 1 repeats/domains (TSR). A TSP1 monomer contains three TSRs, each with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54d15811c8892593baff71af86bff38
https://doi.org/10.1021/bi026463u
https://doi.org/10.1021/bi026463u
Autor:
Jasna Peter-Katalinic, Kristin G. Huwiler, Boris Macek, Daniel Hess, Jan Hofsteenge, Deane F. Mosher, Jack Lawler
Publikováno v:
Journal of Biological Chemistry. 276:6485-6498
Thrombospondin-1 (TSP-1) is a multidomain protein that has been implicated in cell adhesion, motility, and growth. Some of these functions have been localized to the three thrombospondin type 1 repeats (TSRs), modules of approximately 60 amino acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efdcd91d49c6c4c115734a1442dcaf0
https://doi.org/10.1074/jbc.m008073200
https://doi.org/10.1074/jbc.m008073200
Autor:
Deane F. Mosher, Kristin G. Huwiler
Publikováno v:
Japanese Journal of Thrombosis and Hemostasis. 11:315-346
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21bc0f62bac4d9441c25886a712d4093
https://doi.org/10.2491/jjsth.11.315
https://doi.org/10.2491/jjsth.11.315
Publikováno v:
Assay and drug development technologies. 8(3)
In the search for new chemical entities that interact with G-proteincoupled receptors (GPCRs), assays that quantify efficacy and affinity are employed. Traditional methods for measuring affinity involve radiolabeled ligands. To address the need for h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed04170204e4115a414f3e925de691b
https://pubmed.ncbi.nlm.nih.gov/20233092
https://pubmed.ncbi.nlm.nih.gov/20233092
Publikováno v:
Analytical biochemistry. 393(1)
The activation of G-protein-coupled receptors (GPCRs) can result in the stimulation of numerous signaling networks that extend beyond canonical secondary messenger-dependent pathways. It is well-established that many of these diverse networks converg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a4843cd3f5beb1870e19e6d28804b7
https://pubmed.ncbi.nlm.nih.gov/19539597
https://pubmed.ncbi.nlm.nih.gov/19539597
Publikováno v:
Proceedings of the National Academy of Sciences. 88:7615-7619
Alteration of DNA ligase I activity is a consistent biochemical feature of Bloom's syndrome (BS) cells. DNA ligase I activity in BS cells either is reduced and abnormally thermolabile or is present in an anomalously dimeric form. To assess the role o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faaef9debedc52c32775cb50f861c40f
https://doi.org/10.1073/pnas.88.17.7615
https://doi.org/10.1073/pnas.88.17.7615
Autor:
David A. Lasky, Tammy Turek-Etienne, Kristin G Huwiler, Kevin R. Kupcho, Kurt W. Vogel, Tina M. Hallis, Richard Somberg, Rica Bruinsma
Publikováno v:
Current Chemical Genomics
RAF kinases are part of a conserved signaling pathway that impacts cell growth, differentiation, and survival, and RAF pathway dysregulation is an attractive target for therapeutic intervention. We describe two homogeneous fluorescent formats that di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27eae279fdb387c629d030a91defd5e
https://pubmed.ncbi.nlm.nih.gov/20161827
https://pubmed.ncbi.nlm.nih.gov/20161827