Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kristin Fathe"'
Publikováno v:
Open Forum Infectious Diseases. 9
Background In December of 2019, an outbreak of pneumonia was reported to the World Health Organization. The etiology of this outbreak was identified as novel coronavirus (SARS-CoV-2), which has resulted in a global pandemic. The persistence of circul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4918d129ecb5e3251f85d68c22f92e1d
https://doi.org/10.1093/ofid/ofac492.452
https://doi.org/10.1093/ofid/ofac492.452
Autor:
Chris MacDonald, Scott E. Fraser, Dominic Yurk, Aditya Rajagopal, Lucien Jacky, Kristin Fathe, Paul Belitz, John Alvarado
The gold standard of molecular pathogen detection is the quantitative polymerase chain reaction (qPCR). Modern qPCR instruments are capable of detecting 4-6 analytes in a single sample: one per optical detection channel. However, many clinical applic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0e701a7a8a0bfb3c4430e80fc64d14
https://resolver.caltech.edu/CaltechAUTHORS:20210301-100548631
https://resolver.caltech.edu/CaltechAUTHORS:20210301-100548631
Autor:
Ashley Solmonson, Fang G, Shohei Kohno, X.L. Yang, Katsuya Hirasaka, Edward M. Mills, Kristin Fathe, Christopher L. Riley, Christine K. Dao, Matthew Pfeiffer, Takeshi Nikawa, Kenaston A, Sara M. Nowinski
SummarySkeletal muscle mitochondrial fatty acid (FA) overload in response to chronic overnutrition is a prominent pathophysiological mechanism in obesity-induced metabolic disease. Increased disposal of FAs is therefore an attractive strategy for int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1814721598d0c0798add286e494876f7
https://doi.org/10.1101/821637
https://doi.org/10.1101/821637
Publikováno v:
Current Pharmaceutical Design. 22:2501-2521
Background: Delivery of pharmacologically active compounds to the lung for systemic effects is well known and recently has entered a new era with several products achieving regulatory approval. This review focuses on the barriers to pulmonary deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f9a79126e3446b1c3dd6bbb29fd60f
https://doi.org/10.2174/1381612822666160210142910
https://doi.org/10.2174/1381612822666160210142910
Publikováno v:
Current Pharmaceutical Design. 21:5789-5801
This review is intended to provide a critical account of the current goals and technologies of particle engineering regarding the production of crystalline and amorphous particles. The technologies discussed here cover traditional crystallization tec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8989e6635ea44b1c83086b0620c9797a
https://doi.org/10.2174/1381612821666151008150457
https://doi.org/10.2174/1381612821666151008150457
Publikováno v:
The Journal of Nutritional Biochemistry. 26:312-318
Elevated homocysteine levels have long been associated with various disease states, including cardiovascular disease and birth defects, including neural tube defects (NTDs). One hypothesis regarding the strong correlation between these various disord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663d9644527ce64a77c1146277d9f8c4
https://doi.org/10.1016/j.jnutbio.2014.10.004
https://doi.org/10.1016/j.jnutbio.2014.10.004
Publikováno v:
Birth Defects Research Part A: Clinical and Molecular Teratology. 100:592-597
Background Valproic acid (VPA) is a commonly prescribed drug for those affected by epilepsy and bipolar disorders. VPA has a well known teratogenic potential, causing a variety of birth defects including neural tube defects (NTDs) and other congenita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7cfb4c5507dfc4a1dbf90371d2ea779
https://doi.org/10.1002/bdra.23277
https://doi.org/10.1002/bdra.23277
Autor:
Kristin Fathe, Angela Jeanes, Trent M. Woodruff, Richard H. Finnell, Stephen M. Taylor, Kerina J. Denny
Publikováno v:
Birth Defects Research Part A: Clinical and Molecular Teratology. 97:602-609
Periconceptional supplementation with folic acid has led to a significant worldwide reduction in the incidence of neural tube defects (NTDs). However, despite increasing awareness of the benefits of folic acid supplementation and the implementation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa0890521566b44c62c1cf10081e6a69
https://doi.org/10.1002/bdra.23177
https://doi.org/10.1002/bdra.23177
Autor:
Siilvia Ferrati, Ashlee D. Brunaugh, Kristin Fathe, Jason T. McConville, Miguel Montenegro-Nicolini, Song Li, Hugh D. C. Smyth, Mark R. Prausnitz, Zeynab Mousavikhamene, Javier O. Morales
Publikováno v:
The AAPS journal. 19(3)
Biologic products are large molecules such as proteins, peptides, nucleic acids, etc., which have already produced many new drugs for clinical use in the last decades. Due to the inherent challenges faced by biologics after oral administration (e.g.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62caab267f92117a28d21627828b6cd
https://pubmed.ncbi.nlm.nih.gov/28194704
https://pubmed.ncbi.nlm.nih.gov/28194704
Publikováno v:
International journal of pharmaceutics. 494(1)
In recent years, several new genome editing technologies have been developed. Of these the zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the CRISPR/Cas9 RNA-guided endonuclease system are the most widely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffced1c3ac4d5f838ea950a6672840f0
https://pubmed.ncbi.nlm.nih.gov/26278489
https://pubmed.ncbi.nlm.nih.gov/26278489