Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kristin E. Noack Watt"'
Publikováno v:
PLoS Genetics, Vol 12, Iss 7, p e1006187 (2016)
Ribosome biogenesis is a global process required for growth and proliferation of all cells, yet perturbation of ribosome biogenesis during human development often leads to tissue-specific defects termed ribosomopathies. Transcription of the ribosomal
Externí odkaz:
https://doaj.org/article/ee91939c13c04448964b73e21c1fa893
Autor:
George Bugarinovic, Michael J. Dixon, Paul A. Trainor, Mihaela E. Sardiu, Sharien Fitriasari, Jill Dixon, Dai Tsuchiya, Kristin E. Noack Watt, Melissa Childers, Rita Shiang, Daisuke Sakai, Jay R. Unruh, Emma L. Moore, Soma Dash, Annita Achilleos, Ruonan Zhao, Karla T. Falcon, Lin Li, Selene K. Swanson
Ribosomal RNA (rRNA) transcription by RNA Polymerase I (Pol I) is a critical rate-limiting step in ribosome biogenesis, which is essential for cell survival. Despite its global function, disruptions in ribosome biogenesis cause tissue-specific birth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b6c9dfd9a88a819f1745ea01dfdb29e
https://doi.org/10.1101/2021.09.22.461379
https://doi.org/10.1101/2021.09.22.461379
Autor:
Maura McGrail, Julia M Hatler, Xianyan Kuang, Hsin-Kai Liao, Kishore Nannapaneni, Kristin E Noack Watt, Juli D Uhl, David A Largaespada, Erik Vollbrecht, Todd E Scheetz, Adam J Dupuy, Jesse M Hostetter, Jeffrey J Essner
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18826 (2011)
Large-scale sequencing of human cancer genomes and mouse transposon-induced tumors has identified a vast number of genes mutated in different cancers. One of the outstanding challenges in this field is to determine which genes, when mutated, contribu
Externí odkaz:
https://doaj.org/article/2527c50033bc4acc9c059bfb44b5c54e
Ribosome biogenesis is a global process required for growth and proliferation in all cells, but disruptions in this process surprisingly lead to tissue-specific phenotypic disorders termed ribosomopathies. Pathogenic variants in the RNA Polymerase (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed2334b98b7a894ecb6d5f25d884fa1
https://europepmc.org/articles/PMC6927876/
https://europepmc.org/articles/PMC6927876/
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 12, Iss 7, p e1006187 (2016)
PLoS Genetics, Vol 12, Iss 7, p e1006187 (2016)
Ribosome biogenesis is a global process required for growth and proliferation of all cells, yet perturbation of ribosome biogenesis during human development often leads to tissue-specific defects termed ribosomopathies. Transcription of the ribosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1623b073ef9c4a3acdc04e284c71dca8
http://europepmc.org/articles/PMC4957770
http://europepmc.org/articles/PMC4957770
Autor:
Jeffrey J. Essner, Maura McGrail, Chelsy K. Kemmet, Qin Wen, Ying Wang, Justin Breitbach, Kristin E. Noack Watt, Hsin Kai Liao, Karl J. Clark, Stephen C. Ekker
Publikováno v:
Developmental Dynamics. 241:415-425
Background: The single spanning transmembrane amyloid precursor protein (APP) and its proteolytic product, amyloid-beta (Ab) peptide, have been intensely studied due to their role in the pathogenesis of Alzheimer’s disease. However, the biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3f5cfb97e210f322dea5b232fa748e
https://doi.org/10.1002/dvdy.23725
https://doi.org/10.1002/dvdy.23725
Autor:
Naomi E. Butler Tjaden, Brian L. Black, Paul A. Trainor, Kazushi Aoto, Lisa L. Sandell, Kristin E. Noack Watt, Michael Durnin, Kobe C. Yuen
Publikováno v:
Developmental biology, vol 402, iss 1
Neural crest cells (NCC) comprise a multipotent, migratory stem cell and progenitor population that gives rise to numerous cell and tissue types within a developing embryo, including craniofacial bone and cartilage, neurons and glia of the peripheral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f13b024f9e0afb0e66f7064e1636db39
https://escholarship.org/uc/item/2rb9262n
https://escholarship.org/uc/item/2rb9262n
Autor:
Joaquin Navajas Acedo, Patricia L. Bender, Robert J. Hopkin, Charles Marques Lourenço, Robert B. Hufnagel, Rainer König, Luke L. Linscott, K. Nicole Weaver, Dagmar Wieczorek, Paul A. Trainor, Kristin E. Noack Watt, Dietmar R. Lohmann, Howard M. Saal, Ute Hehr, Kristen L. Sund
We report three individuals with a cranioskeletal malformation syndrome that we define as acrofacial dysostosis, Cincinnati type. Each individual has a heterozygous mutation in POLR1A, which encodes a core component of RNA polymerase 1. All three ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e2483159730aaf3f51070877e5c596
https://www.ncbi.nlm.nih.gov/pubmed/25913037
https://www.ncbi.nlm.nih.gov/pubmed/25913037
Autor:
Paul A. Trainor, Kristin E. Noack Watt
Neural crest cells (NCC) are a migratory stem and progenitor cell population established early in development from the time of gastrulation through to organogenesis. As discussed in previous chapters, NCC are induced at the neural plate border, the j
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75985d6a3136d725e55c37aa8d4496d5
https://doi.org/10.1016/b978-0-12-401730-6.00018-1
https://doi.org/10.1016/b978-0-12-401730-6.00018-1
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab3ad40dffffd0c5b2c677d731198d19
https://doi.org/10.1096/fasebj.27.1_supplement.21.3
https://doi.org/10.1096/fasebj.27.1_supplement.21.3