Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kristin E. Burns"'
Autor:
Susan Zhang, Kristin E. Burns-Huang, Guido V. Janssen, Huilin Li, Huib Ovaa, Lizbeth Hedstrom, K. Heran Darwin
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT The protein degradation machinery of Mycobacterium tuberculosis includes a proteasome and a ubiquitin-like protein (Pup). Proteasome accessory factor A (PafA) attaches Pup to proteins to target them for degradation by the proteasome. Free Pu
Externí odkaz:
https://doaj.org/article/d2b74ebe65b244948a736ea43510d1c5
Autor:
Richard A. Festa, Fiona McAllister, Michael J. Pearce, Julian Mintseris, Kristin E. Burns, Steven P. Gygi, K. Heran Darwin
Publikováno v:
PLoS ONE, Vol 5, Iss 7 (2010)
Externí odkaz:
https://doaj.org/article/ad10e9dfb35c4d41b83285b2584d5760
Autor:
Francisca A. Cerda-Maira, Huib Ovaa, Stevan R. Hubbard, Julian Mintseris, Kristin E. Burns, K. Heran Darwin, Fiona E. McAllister, Steven P. Gygi, Elke E. Noens, Francesco D. Melandri, Matthias Wilmanns, Carsten Schwerdtfeger
Publikováno v:
Journal of Biological Chemistry. 287:37522-37529
Deamidase of Pup (Dop), the prokaryotic ubiquitin-like protein (Pup)-deconjugating enzyme, is critical for the full virulence of Mycobacterium tuberculosis and is unique to bacteria, providing an ideal target for the development of selective chemothe
Autor:
Kristin E. Burns, Dris El Atmioui, Remco Merkx, K. Heran Darwin, Farid El Oualid, Huib Ovaa, Paul Slobbe
Publikováno v:
Chembiochem
A litter of pups: The synthesis and in vitro evaluation of new Pup-based fluorogenic substrates for Dop, the mycobacterial depupylase, are described. A full-length Pup-amidomethylcoumarin conjugate as well as an amino-terminus-truncated analogue exhi
Autor:
Francisca A. Cerda-Maira, William R. Bishai, Kristin E. Burns, Huilin Li, K. Heran Darwin, Tao Wang
Publikováno v:
Molecular Cell. 39(5):821-827
Ubiquitin (Ub) provides the recognition and specificity required to deliver proteins to the eukaryotic proteasome for destruction. Prokaryotic ubiquitin-like protein (Pup) is functionally analogous to Ub in Mycobacterium tuberculosis (Mtb) as it doom
Publikováno v:
Journal of Biological Chemistry. 284:3069-3075
The striking identification of an apparent proteasome core in Mycobacteria and allied actinomycetes suggested that additional elements of this otherwise strictly eukaryotic system for regulated protein degradation might be conserved. The genes encodi
Autor:
Abhishek Chatterjee, Pieter C. Dorrestein, Kristin E. Burns, Jeremiah Hanes, Tadhg P. Begley, David G. Hilmey
Publikováno v:
Journal of the American Chemical Society. 130:3043-3052
Two routes for the de novo biosynthesis of pyridoxal-5'-phosphate (PLP) have been discovered and reconstituted in vitro. The most common pathway that organisms use is dependent upon the activity of just two enzymes, known as Pdx1 (YaaD) and Pdx2 (Yaa
Publikováno v:
Biochemistry. 45:14609-14620
Pyridoxal 5'-phosphate (PLP) is the biologically active form of vitamin B6 and is an important cofactor for several of the enzymes involved in the metabolism of amine-containing natural products such as amino acids and amino sugars. The PLP synthase
Autor:
Olaf S. Andersen, Xiuju Jiang, Nan Zhao, Crystal M. Darby, J. David Warren, Steven J. Brickner, Chun Shen, Sabine Ehrt, Helgi I. Ingólfsson, Carl Nathan, Kristin E. Burns, Mingna Sun, Gang Liu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 8 (2013)
PLoS ONE, Vol 8, Iss 8 (2013)
Autor:
Jennifer Garbarini, Dianne Gallagher, Meghan K Mac Neal, Michelle Olive, Josée Dupuis, Emma Marquez, Jessica Tusi, Bruce D. Gelb, Mike Italia, Laura E. Mitchell, Roger E. Breitbart, Elaine Mardis, Lynn A. Sleeper, Gail D. Pearson, Nhu Tran, Cassie Mintz, Elizabeth Goldmuntz, Rosalind Korsin, Kristin E. Burns, Joel H. Saltz, Inga Peter, Denise Guevara, Stacy Woyciechowski, Howard S. Seiden, Hakon Hakonarson, Christine Beiswanger, Hector R. Wong, Steven D. Colan, Kimberly Dandreo, James Bristow, Davina Etwaru, Ellen Rosenberg, Ariel Julian, Jeffrey Botkin, George A. Porter, Richard B. Kim, Jennie Kline, Peter White, Christina Kendziorski, Barbara McDonough, Ismee A. Williams, Nancy Stellato, Ravi Sachidanandam, Clinical Sites, Vidu Garg, Minmin Lu, Katrina Celia, John E. Deanfield, Charlene Schramm, Dorothy Warburton, Juan Pablo Kaski, Amy E. Roberts, Maria M. Brooks, Abigail Wilpers, Martina Brueckner, Christine E. Seidman, Alyssa Lanz, Jeffrey C. Murray, Dorit Berlin, Jonathan R. Kaltman, Todd Evans, Judith Geva, Karen Flack, Sharon Edman, Angela Monafo, Jane Newburger, Jonathan G. Seidman, Angela Romano-Adesman, Eileen Taillie, Laura Mercer-Rosa, Janice Stryker, Jaswinder Kaur Sond, Nancy Cross, Sharon Tennstedt, Roslyn Yee, Michael S. Watson, Danielle Awad, Dorota Gruber, Richard P. Lifton, Alessandro Giardini, Wendy K. Chung
Publikováno v:
Circulation research. 112(4)
Congenital heart defects (CHD) are the leading cause of infant mortality among birth defects, and later morbidities and premature mortality remain problematic. Although genetic factors contribute significantly to cause CHD, specific genetic lesions a