Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kristin D. Lane"'
Autor:
Sean T. Windle, Kristin D. Lane, Nahla B. Gadalla, Anna Liu, Jianbing Mu, Ramoncito L. Caleon, Rifat S. Rahman, Juliana M. Sá, Thomas E. Wellems
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 14, Iss , Pp 208-217 (2020)
Background: Lumefantrine and mefloquine are used worldwide in artemisinin-based combination therapy (ACT) of malaria. Better understanding of drug susceptibility and resistance is needed and can be obtained from studies of genetic crosses. Methods: D
Externí odkaz:
https://doaj.org/article/03ffa978d77c4154a1e5c0ec24f5c94f
Autor:
Brajesh K. Singh, Cui Zhang, Jian Wu, Yu-Chih Peng, Xiao He, Keyla C. Tumas, Juliana M. Sá, Kristin D. Lane, Richard T. Eastman, David L. Narum, Thomas E. Wellems, Xin-zhuan Su
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Protein ubiquitination is an important posttranslational regulation mechanism that mediates Plasmodium development and modifies parasite responses to antimalarial drugs. Although mutations in several parasite ubiquitination enzymes have been linked t
Autor:
Thomas E. Wellems, Sean T. Windle, Jianbing Mu, Rifat S. Rahman, Juliana M. Sá, Nahla B Gadalla, Ramoncito L. Caleon, Kristin D. Lane, Anna Liu
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 14, Iss, Pp 208-217 (2020)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
Background Lumefantrine and mefloquine are used worldwide in artemisinin-based combination therapy (ACT) of malaria. Better understanding of drug susceptibility and resistance is needed and can be obtained from studies of genetic crosses. Methods Dru
Autor:
T. Parks Remcho, Carole A. Bewley, Phillip Cruz, Gavin D. Heffernan, Thomas E. Wellems, Glenn Nardone, Kristin D. Lane, Robert D. O’Connor, Sravanthi D. Guggilapu
Publikováno v:
Antimicrob Agents Chemother
WR99210, a former antimalarial drug candidate now widely used for the selection of Plasmodium transfectants, selectively targets the parasite’s dihydrofolate reductase thymidine synthase bifunctional enzyme (DHFR-TS) but not human DHFR, which is no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498883b055d4c053f6031ce91b69584a
https://europepmc.org/articles/PMC7927815/
https://europepmc.org/articles/PMC7927815/
Autor:
Sravanthi D. Guggilapu, Thomas E. Wellems, Glenn Nardone, Robert D. O’Connor, T. Parks Remcho, Carole A. Bewley, Kristin D. Lane, Phillip Cruz, Gavin D. Heffernan
WR99210, a former antimalarial drug candidate now widely used for the selection of Plasmodium transfectants, selectively targets the parasite dihydrofolate reductase thymidine synthase bifunctional enzyme (DHFR-TS) but not human DHFR, which is not fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4d95d855f60ba83b0c529e075fdb197
https://doi.org/10.1101/2020.07.01.182402
https://doi.org/10.1101/2020.07.01.182402
Autor:
Jianbing Mu, Kristin D. Lane, Anna Liu, Thomas E. Wellems, Jinghua Lu, Peter D. Sun, Sean T. Windle
Publikováno v:
Proceedings of the National Academy of Sciences. 115:6285-6290
Malaria control is threatened by a limited pipeline of effective pharmaceuticals against drug-resistant strains of Plasmodium falciparum. Components of the mitochondrial electron transport chain (ETC) are attractive targets for drug development, owin
Publikováno v:
Clin Microbiol Rev
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that continues to afflict hundreds of millions of people every year. Infections with malaria parasites can be asymptomatic, with mild or severe symptoms, or fatal, d
Autor:
Kristin D. Lane, Gail E. Christie, José R. Penadés, Richard P. Novick, Krishan Kumar, Geeta Ram, John Chen, Hope F. Ross, Carles Ubeda, Priyadarshan K. Damle
Publikováno v:
Proceedings of the National Academy of Sciences. 109:16300-16305
Staphylococcal pathogenicity islands (SaPIs) carry superantigen and resistance genes and are extremely widespread in Staphylococcus aureus and in other Gram-positive bacteria. SaPIs represent a major source of intrageneric horizontal gene transfer an
Autor:
Martin J. Smilkstein, Rolf W. Winter, Roland A. Cooper, Aaron Janowsky, Jane X. Kelly, Michael K. Riscoe, David J. Hinrichs, Sergio Wittlin, Reto Brun, Robert A. Johnson, Kristin D. Lane, Rozalia Dodean
Publikováno v:
Nature
Preventing and delaying the emergence of drug resistance is an essential goal of antimalarial drug development. Monotherapy and highly mutable drug targets have each facilitated resistance, and both are undesirable in effective long-term strategies a
a Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, PO Box 980678, Richmond, VA 23298-0678, USA b Centre of Biological Engineering, IBB – Institute for Biotechnology and Bioengineering, University of Mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45094dfe299c88a0859b2652128e9ce
https://hdl.handle.net/1822/35266
https://hdl.handle.net/1822/35266