Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models

Autor: Somshuvra Bhattacharya, Kristin Calar, Pilar de la Puente

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-16 (2020)

Abstract The heterogeneous tumor microenvironment (TME) is highly complex and not entirely understood. These complex configurations lead to the generation of oxygen-deprived conditions within the tumor niche, which modulate several intrinsic TME elem

Externí odkaz: https://doaj.org/article/8d851f5aa384425d9eb589cfae3edb00

Reduction of Metastasis via Epigenetic Modulation in a Murine Model of Metastatic Triple Negative Breast Cancer (TNBC)

Autor: Jessica L. S. Zylla, Mariah M. Hoffman, Simona Plesselova, Somshuvra Bhattacharya, Kristin Calar, Yohannes Afeworki, Pilar de la Puente, Etienne Z. Gnimpieba, W. Keith Miskimins, Shanta M. Messerli

Publikováno v: Cancers; Volume 14; Issue 7; Pages: 1753

This study investigates the effects of a dual selective Class I histone deacetylase (HDAC)/lysine-specific histone demethylase 1A (LSD1) inhibitor known as 4SC-202 (Domatinostat) on tumor growth and metastasis in a highly metastatic murine model of T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f40f65ffdf1daeab566f21480d0e545
https://pubmed.ncbi.nlm.nih.gov/35406526

Human Plasma-Derived 3D Cultures Model Breast Cancer Treatment Responses and Predict Clinically Effective Drug Treatment Concentrations

Autor: Pilar de la Puente, Simona Plesselova, Kristin Calar, Megan Jorgensen, Somshuvra Bhattacharya

Publikováno v: Cancers
Cancers, Vol 12, Iss 1722, p 1722 (2020)
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Volume 12
Issue 7

Lack of efficacy and a low overall success rate of phase I-II clinical trials are the most common failures when it comes to advancing cancer treatment. Current drug sensitivity screenings present several challenges including differences in cell growt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf276d2fd9b82da6a34c9d67eba6c37
https://pubmed.ncbi.nlm.nih.gov/32610529

Bioengineering a novel 3D in-vitro model to recreate physiological oxygen levels and tumor-immune interactions

Autor: Kristin Calar, Somshuvra Bhattacharya, Claire Evans, Mark Petrasko, Pilar de la Puente

Oxygen deprivation within tumors is one of the most prevalent causes of resilient cancer cell survival and increased immune evasion in breast cancer (BCa). Current in vitro models do not adequately mimic physiological oxygen levels relevant to breast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d522ca989921ce84d3b6ba066d27f9e2
https://doi.org/10.1101/828145

Abstract B29: Modeling the oxygen-deprived breast cancer tumor microenvironment within a three-dimensional bioengineered platform that exhibits hypoxia-driven immune evasion

Autor: Pilar de la Puente, Kristin Calar, Somshuvra Bhattacharya, Claire Evans

Publikováno v: Cancer Research. 80:B29-B29

Introduction: Oxygen deprivation within tumors has been associated with enhanced cancer cell survival, altered extracellular matrix (ECM) production, and increased immune evasion in breast cancer (BCa). These outcomes collectively contribute to chemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f367763de503b4fef0c7c4ac0c955730
https://doi.org/10.1158/1538-7445.camodels2020-b29