Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kristin C. Hicks"'
Autor:
Kristin C. Hicks, Paul L. Chariou, Yohei Ozawa, Christine M. Minnar, Karin M. Knudson, Thomas J. Meyer, Jing Bian, Margaret Cam, Jeffrey Schlom, Sofia R. Gameiro
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The immunocytokine NHS-IL12 is targeted to necrotic tumour areas to prompt an immune response. Authors show here in mouse colon and breast models that the combination of histone deacetylase inhibitor, Entinostat, and NHS-IL12 generates a tumour micro
Externí odkaz:
https://doaj.org/article/9ae4f4dff32d41159c913dd23783fab3
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Background Immunotherapy targeting PD-1/PD-L1 fails to induce clinical responses in most patients with solid cancers. N-803, formerly ALT-803, is an IL-15 superagonist mutant and dimeric IL-15RαSushi-Fc fusion protein complex that enhances
Externí odkaz:
https://doaj.org/article/01c44dbd09c141fa93bc655b4604641d
Autor:
Margaret E. Gatti-Mays, Sofia R. Gameiro, Yohei Ozawa, Karin M. Knudson, Kristin C. Hicks, Claudia Palena, Lisa M. Cordes, Seth M. Steinberg, Deneise Francis, Fatima Karzai, Stanley Lipkowitz, Renee N. Donahue, Caroline Jochems, Jeffrey Schlom, James L. Gulley
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Breast tumors commonly harbor low mutational burden, low PD-L1 expression, defective antigen processing/presentation, and an immunosuppressive tumor microenvironment (TME). In a malignancy mostly refractory to checkpoint blockade, there is an unmet c
Externí odkaz:
https://doaj.org/article/3b635c718c7d46879728beddc14329cb
Autor:
Yohei Ozawa, Kristin C. Hicks, Christine M. Minnar, Karin M. Knudson, Jeffrey Schlom, Sofia R. Gameiro
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Most monoclonal antibodies (MAbs), including immune checkpoint inhibitor MAbs, are delivered intravenously (i.v.) to patients. Recent clinical studies have demonstrated that some anti-PD1 MAbs may also be delivered subcutaneously (s.c.), with clinica
Externí odkaz:
https://doaj.org/article/50767b5a22ba444eb449605c918b8780
Autor:
Kristin C. Hicks, Massimo Fantini, Renee N. Donahue, Angie Schwab, Karin M. Knudson, Sarah R. Tritsch, Caroline Jochems, Paul E. Clavijo, Clint T. Allen, James W. Hodge, Kwong Y. Tsang, Jeffrey Schlom, Sofia R. Gameiro
Publikováno v:
OncoImmunology, Vol 7, Iss 11 (2018)
Checkpoint inhibitors targeting the PD-1/PD-L1 axis are promising immunotherapies shown to elicit objective responses against multiple tumor types, yet these agents fail to benefit most patients with carcinomas. This highlights the need to develop ef
Externí odkaz:
https://doaj.org/article/969459ae66554e98b6f7f3e909e56f34
Autor:
Karin M. Knudson, Kristin C. Hicks, Xiaoling Luo, Jin-Qiu Chen, Jeffrey Schlom, Sofia R. Gameiro
Publikováno v:
OncoImmunology, Vol 7, Iss 5 (2018)
Tumors evade host immune surveillance through multiple mechanisms, including the generation of a tumor microenvironment that suppresses immune effector function. Secretion of TGFβ and upregulation of immune checkpoint programmed cell death ligand-1
Externí odkaz:
https://doaj.org/article/af53615042e34956bc1760a99c159220
Autor:
Duane H. Hamilton, Jeffrey Schlom, Kayvan Niazi, Patrick Soon-Shiong, Shahrooz Rabizadeh, John H. Lee, Lars Rohlin, Peter Ordentlich, Zhen Su, John Z. Sanborn, Claudia Palena, Sofia R. Gameiro, Andrew Nguyen, Kristin C. Hicks, Stephen C. Benz, Karin L. Lee
Supplementary figures and tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76402d3621e33d3448c35be905e61c29
https://doi.org/10.1158/2326-6066.22542444
https://doi.org/10.1158/2326-6066.22542444
Autor:
Duane H. Hamilton, Jeffrey Schlom, Kayvan Niazi, Patrick Soon-Shiong, Shahrooz Rabizadeh, John H. Lee, Lars Rohlin, Peter Ordentlich, Zhen Su, John Z. Sanborn, Claudia Palena, Sofia R. Gameiro, Andrew Nguyen, Kristin C. Hicks, Stephen C. Benz, Karin L. Lee
Progressive tumor growth is associated with deficits in the immunity generated against tumor antigens. Vaccines targeting tumor neoepitopes have the potential to address qualitative defects; however, additional mechanisms of immune failure may underl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3729fdc3b7646646a9bd407d7f4fe26d
https://doi.org/10.1158/2326-6066.c.6549930.v1
https://doi.org/10.1158/2326-6066.c.6549930.v1
Autor:
Sofia R. Gameiro, Jeffrey Schlom, Patrick Soon-Shiong, Shahrooz Rabizadeh, Frank R. Jones, Peter Ordentlich, William D. Figg, James W. Hodge, Duane H. Hamilton, Karin L. Lee, Karin M. Knudson, Kristin C. Hicks
Purpose:Immunotherapy has demonstrated clinical efficacy in subsets of patients with solid carcinomas. Multimodal therapies using agents that can affect different arms of the immune system and/or tumor microenvironment (TME) might increase clinical r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257ac866c6a46a82c5d0490c769eeba2
https://doi.org/10.1158/1078-0432.c.6528504.v1
https://doi.org/10.1158/1078-0432.c.6528504.v1
Autor:
Sofia R. Gameiro, Jeffrey Schlom, Patrick Soon-Shiong, Shahrooz Rabizadeh, Frank R. Jones, Peter Ordentlich, William D. Figg, James W. Hodge, Duane H. Hamilton, Karin L. Lee, Karin M. Knudson, Kristin C. Hicks
Methods: depletion studies, immunofluorescence, assays, serum cytokines and plasma TGFbeta, RNA extraction and NanoString analysis, Human HD PBMCs. Figures: effects of entinostat and combination therapy. Tables: antibodies used for flow cytometry sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37708f337fa8068b72923db5a65d3556
https://doi.org/10.1158/1078-0432.22473414
https://doi.org/10.1158/1078-0432.22473414