Výsledky vyhledávání - "Kristin C. Dempsey"

Abstract 4245: Drug response metrics and pharmacological profiling using the OncoPanel™ cell-based profiling service

Autor: Tracy Lu, Vanessa L. Norman, Lee R. Cavedine, Kayla A. Stehle, Steven M. Garner, Natiya E. Robinson, Alyssa M. Croff, Jesse J. Parry, Victoria V. McBain, Kristin C. Dempsey, Joseph T. Murphy, Charles R. Wageman, Brogan A. Epkins, Alastair J. King

Publikováno v: Cancer Research. 79:4245-4245

High-throughput, cell-based drug screening platforms are essential to guiding drug discovery programs and can rapidly generate large amounts of pharmacological information about a candidate drug. Drug response data combined with genomic and phenotypi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b1877cd935a71a2e4979be6b16ca31b
https://doi.org/10.1158/1538-7445.am2019-4245

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Abstract 2073: Profiling and comparison of breast cancer standard of care agents using the OncoPanel™ cell-based profiling service

Autor: Alastair J. King, Natiya E. Robinson, Kayla A. Stehle, Steven M. Garner, Jesse J. Parry, Vanessa L. Norman, Kristin C. Dempsey, Joseph W. Murphy, Charles R. Wageman, Alyssa M. Croff, Lee R. Cavedine, Tracy Lu, Brogan A. Epkins, Victoria V. McBain

Publikováno v: Cancer Research. 79:2073-2073

Oncology drugs with clinical utility for the treatment of breast cancer span a wide range of different mechanisms and cancer type profiles. Anti-cancer therapies have come a long way from the early use of broad spectrum, cytotoxic agents, with mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65da7b56300a4d0b4d38de7f203443bb
https://doi.org/10.1158/1538-7445.am2019-2073

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Abstract 2260: Exploring drug response metrics for biomarker discovery using the OncoPanel™ cell-based profiling service

Autor: Natiya E. Robinson, Alyssa M. Croff, Vanessa L. Norman, Alastair J. King, Brogan A. Epkins, Lee R. Cavedine, Steven M. Garner, Jesse J. Parry, Kristin C. Dempsey, Charles R. Wageman, Usha Warrior

Publikováno v: Cancer Research. 78:2260-2260

Using drug response data, generated by the OncoPanelTM cell-based profiling service, we investigated the differences between traditional and normalized growth rate inhibition (GR) metrics in drug sensitivity classification and predictive genomic biom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e38cfbfa89a47624d143a3893c53e5d6
https://doi.org/10.1158/1538-7445.am2018-2260

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Abstract 1391: Establishment and validation of a high-content imaging assay with a 14-day incubation for the testing of epigenetic target-based therapeutics

Autor: Usha Warrior, Timothy J. Sindelar, Natiya E. Robinson, Vanessa L. Norman, Kristin C. Dempsey, Brogan A. Epkins, Alastair J. King, Charles R. Wageman, Lee R. Cavedine, Steven M. Garner, Jesse J. Parry, Alyssa M. Croff

Publikováno v: Cancer Research. 78:1391-1391

Given the importance and significance of targeting mutations and epigenetic modification in cancer therapy, we sought to expand on our ability to test drugs with epigenetic modulatory abilities by increasing the exposure time of drugs against cell li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41557ed67d82a04d983a177cb5d99836
https://doi.org/10.1158/1538-7445.am2018-1391

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