Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kristin Abrams"'
Autor:
John B. Cheng, Ajith V. Kamath, Douglas A. Fisher, Kelvin Lam, R. J. Chambers, Joann D. Pillar, Tessa A. Castleberry, Kristin Abrams, David Nettleton, John P. Umland, J.T. Shirley, C R Turner, Anthony Marfat, Alissa L. Sheils, E. D. Salter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:718-721
Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d23e0f0dd362554a78f820bb3c0f7b6
https://doi.org/10.1016/j.bmcl.2005.10.026
https://doi.org/10.1016/j.bmcl.2005.10.026
Autor:
Kristin Abrams, Lawrence F. Brown, Shu-Ching Shih, Andrew Mullen, Martin P. Keough, Kevin P. Claffey
Publikováno v:
Laboratory Investigation. 81:61-75
Angiogenesis is a key component of human cancer progression and metastasis. In an effort to recapitulate early events in tumor-induced angiogenesis, we have employed a subcutaneous Matrigel implant model using immunodeficient mice as hosts. Matrigel-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30afc651f4195e45d208ad380c12ebc
https://doi.org/10.1038/labinvest.3780212
https://doi.org/10.1038/labinvest.3780212
Autor:
A. Samuel Vellekoop, Douglas A. Otte, R. J. Chambers, Norman Y. Garceau, David A. Tess, Ajith V. Kamath, Christopher M. Manley, Alissa L. Sheils, Susan C. Lilley, Kelvin Lam, Dennis O. Scott, Kristin Abrams, Yan Zhang
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(2)
Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd92f67fa405782ff8ca80f9872d12b
https://pubmed.ncbi.nlm.nih.gov/16275071
https://pubmed.ncbi.nlm.nih.gov/16275071
Publikováno v:
The Journal of biological chemistry. 274(22)
Aberrant expression of the potent angiogenic cytokine, vascular endothelial growth factor (VEGF), has been demonstrated to be associated with most human solid tumors. Both transcriptional and post-transcriptional mechanisms have been shown to modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171c28abf805bb34b2a77341a04a6c81
https://pubmed.ncbi.nlm.nih.gov/10336429
https://pubmed.ncbi.nlm.nih.gov/10336429
Autor:
Sam W. Lee, Michael Detmar, Jennifer L. Cusick, Andrew Mullen, Kevin P. Claffey, Shu-Ching Shih, Kristin Abrams, Suzan Dziennis
Publikováno v:
Molecular biology of the cell. 9(2)
Hypoxia is a prominent feature of malignant tumors that are characterized by angiogenesis and vascular hyperpermeability. Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) has been shown to be up-regulated in the vicinity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf38de8d5acc761663b23053b07195ab
https://pubmed.ncbi.nlm.nih.gov/9450968
https://pubmed.ncbi.nlm.nih.gov/9450968
Autor:
Cantin, Greg1 (AUTHOR) gcantin@amgen.com, Liu, Qian1 (AUTHOR), Shah, Bhavana1 (AUTHOR), Kuhns, Scott1 (AUTHOR), Wikström, Mats1 (AUTHOR), Cao, Shawn1 (AUTHOR), Liu, Jennifer1 (AUTHOR)
Publikováno v:
Drugs in R&D. Dec2023, Vol. 23 Issue 4, p421-438. 18p.
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