Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kristin A. Krukenberg"'
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1808-1818 (2014)
Poly(ADP-ribose) polymerases (PARPs) catalyze poly(ADP-ribose) addition onto proteins, an important posttranslational modification involved in transcription, DNA damage repair, and stem cell identity. Previous studies established the activation of PA
Externí odkaz:
https://doaj.org/article/9a74eeeafbc34a3989a4ce63c759f033
Autor:
Gary S. McDowell, Kearney T. W. Gunsalus, Drew C. MacKellar, Sarah A. Mazzilli, Vaibhav P. Pai, Patricia R. Goodwin, Erica M. Walsh, Avi Robinson-Mosher, Thomas A. Bowman, James Kraemer, Marcella L. Erb, Eldi Schoenfeld, Leila Shokri, Jonathan D. Jackson, Ayesha Islam, Matthew D. Mattozzi, Kristin A. Krukenberg, Jessica K. Polka
Publikováno v:
F1000Research, Vol 3 (2015)
The landscape of scientific research and funding is in flux as a result of tight budgets, evolving models of both publishing and evaluation, and questions about training and workforce stability. As future leaders, junior scientists are uniquely poise
Externí odkaz:
https://doaj.org/article/5e9ec38a40ce47f2a9983bea42a6cce8
Autor:
David W. Frederick, Joseph A. Baur, Sheng Hui, Karthikeyani Chellappa, Joshua D. Rabinowitz, William J. Quinn, Timothy J. Mitchison, Le Zhan, Kristin A. Krukenberg, Xiaoyang Su, Ling Liu, Philip Redpath, Marie E. Migaud, Eileen White
The redox cofactor nicotinamide adenine dinucleotide (NAD) plays a central role in metabolism and is a substrate for signaling enzymes including poly-ADP-ribose-polymerases (PARPs) and sirtuins. NAD concentration falls during aging, which has trigger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40aee0c901e93dbe5c0801a3154280e8
https://europepmc.org/articles/PMC5932087/
https://europepmc.org/articles/PMC5932087/
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1808-1818 (2014)
Poly(ADP-ribose) polymerases (PARPs) catalyze poly(ADP-ribose) addition onto proteins, an important post-translational modification involved in transcription, DNA damage repair, and stem cell identity. Previous studies established the activation of P
Publikováno v:
Molecular Biology of the Cell
There is a common misconception that the United States is suffering from a “STEM shortage,” a dearth of graduates with scientific, technological, engineering, and mathematical backgrounds. In biomedical science, however, we are likely suffering f
Publikováno v:
Protein Science. 21:1162-1171
Hsp90, a dimeric ATP-dependent molecular chaperone, is required for the folding and activation of numerous essential substrate “client” proteins including nuclear receptors, cell cycle kinases, and telomerase. Fundamental to its mechanism is an e
Publikováno v:
Journal of Molecular Biology. 390:278-291
The molecular chaperone Hsp90 depends upon large conformational rearrangements for its function. One driving force for these rearrangements is the intrinsic ATPase activity of Hsp90, as seen with other chaperones. However, unlike other chaperones, st
Publikováno v:
Protein Science. 18:1815-1827
The molecular chaperone, Hsp90, is an essential eukaryotic protein that assists in the maturation and activation of client proteins. Hsp90 function depends upon the binding and hydrolysis of ATP, which causes large conformational rearrangements in th
Publikováno v:
Science.
Most scientists (ourselves included) headed off to graduate school eager to discover new things, test crazy ideas, and hopefully change the world, or at least explain a piece of it. Sadly, these days such aspirations are overshadowed by fierce compet
Publikováno v:
Chemistrybiology. 22(4)
SummaryPoly(ADP-ribose) polymerase 1 (PARP1) synthesizes poly(ADP-ribose) (PAR), an essential post-translational modification whose function is important in many cellular processes including DNA damage signaling, cell death, and inflammation. All kno