Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Kristin A Eckert"'
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251188 (2021)
DNA polymerases play essential functions in replication fork progression and genome maintenance. DNA lesions and drug-induced replication stress result in up-regulation and re-localization of specialized DNA polymerases η and κ. Although oncogene a
Externí odkaz:
https://doaj.org/article/a9cdf275d3554c9b928c3764329a67ce
Autor:
Guruprasad Ananda, Suzanne E Hile, Amanda Breski, Yanli Wang, Yogeshwar Kelkar, Kateryna D Makova, Kristin A Eckert
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004498 (2014)
Interruptions of microsatellite sequences impact genome evolution and can alter disease manifestation. However, human polymorphism levels at interrupted microsatellites (iMSs) are not known at a genome-wide scale, and the pathways for gaining interru
Externí odkaz:
https://doaj.org/article/a2f12fa98803456895ba38bb9bbebe23
Autor:
Ning Wang, Kristin A Eckert, Ali R Zomorrodi, Ping Xin, Weihua Pan, Debra A Shearer, Judith Weisz, Costas D Maranus, Gary A Clawson
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39446 (2012)
Expression of the serine protease HtrA1 is decreased or abrogated in a variety of human primary cancers, and higher levels of HtrA1 expression are directly related to better response to chemotherapeutics. However, the precise mechanisms leading to Ht
Externí odkaz:
https://doaj.org/article/a9961bde03c94bccb03f60e1ddc45556
Neoplastic transformation and genome instability are enhanced by replication stress, conditions that slow or stall DNA replication forks. Consequently, cancer cells require multiple enzymes and checkpoint signaling pathways to mitigate replication st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::506647b5f65dd103b501d89edb9f0e26
https://doi.org/10.1158/0008-5472.c.6510099.v1
https://doi.org/10.1158/0008-5472.c.6510099.v1
Supplementary Table 1 and Figures S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3671c7e24fa238f430468812995a8db2
https://doi.org/10.1158/0008-5472.22418322.v1
https://doi.org/10.1158/0008-5472.22418322.v1
Autor:
Kristin A. Eckert, Sandeep N. Shah
The mismatch repair (MMR) system plays a major role in removing DNA polymerization errors, and loss of this pathway results in hereditary cancers characterized by microsatellite instability. We investigated microsatellite stability during DNA replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aa439d583bfe80c6842e590f3ca966e
https://doi.org/10.1158/0008-5472.c.6499356.v1
https://doi.org/10.1158/0008-5472.c.6499356.v1
Variation in G-quadruplex Sequence and Topology Differentially Impacts Human DNA Polymerase Fidelity
Autor:
MaryElizabeth Stein, Suzanne E. Hile, Matthias H. Weissensteiner, Marietta Lee, Sufang Zhang, Eduard Kejnovský, Iva Kejnovská, Kateryna D. Makova, Kristin A. Eckert
Publikováno v:
DNA Repair (Amst)
G-quadruplexes (G4s), a type of non-B DNA, play important roles in a wide range of molecular processes, including replication, transcription, and translation. Genome integrity relies on efficient and accurate DNA synthesis, and is compromised by vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a3d1669381473755166e400d871c4e
https://europepmc.org/articles/PMC9798401/
https://europepmc.org/articles/PMC9798401/
Autor:
Matthias H. Weissensteiner, Marzia A. Cremona, Wilfried Guiblet, Nicholas Stoler, Robert S. Harris, Monika Cechova, Kristin A. Eckert, Francesca Chiaromonte, Yi-Fei Huang, Kateryna D. Makova
Modern sequencing technologies are not error-free, and might have elevated error rates at some locations of the genome. A potential cause for such elevated error rates is the formation of alternative DNA structures (non-B DNA), such as G-quadruplexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::840e50932a97cad2f3dee5b0659bed7b
https://doi.org/10.1101/2022.06.13.495922
https://doi.org/10.1101/2022.06.13.495922
Publikováno v:
Genes. 14:893
Mutations of numerous genes involved in DNA replication, DNA repair, and DNA damage response (DDR) pathways lead to a variety of human diseases, including aging and cancer [...]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c025b4029a96250bf88c6b46d0d6636
https://doi.org/10.3390/genes14040893
https://doi.org/10.3390/genes14040893
Autor:
Kateryna D. Makova, Kristin A. Eckert, Francesca Chiaromonte, Yi-Fei Huang, Wilfried Guiblet, Di Chen, Robert S. Harris, Marzia A. Cremona
Publikováno v:
Nucleic Acids Research
Approximately 13% of the human genome can fold into non-canonical (non-B) DNA structures (e.g. G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular processes. Non-B DNA also hinders replication, increasing errors and facilitatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9c29e74579ff0758e313b47ac07527
https://doi.org/10.1093/nar/gkaa1269
https://doi.org/10.1093/nar/gkaa1269