Výsledky vyhledávání - "Kristin A Eckert"

Akademický článek

Overexpression of oncogenic H-Ras in hTERT-immortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion.

Autor: Wei-Chung Tsao, Raquel Buj, Katherine M Aird, Julia M Sidorova, Kristin A Eckert

Publikováno v: PLoS ONE, Vol 16, Iss 5, p e0251188 (2021)

DNA polymerases play essential functions in replication fork progression and genome maintenance. DNA lesions and drug-induced replication stress result in up-regulation and re-localization of specialized DNA polymerases η and κ. Although oncogene a

Externí odkaz: https://doaj.org/article/a9cdf275d3554c9b928c3764329a67ce

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Data from DNA Polymerase Eta Prevents Tumor Cell-Cycle Arrest and Cell Death during Recovery from Replication Stress

Autor: Kristin A. Eckert, George-Lucian Moldovan, Wei-Chung Tsao, Ryan P. Barnes

Neoplastic transformation and genome instability are enhanced by replication stress, conditions that slow or stall DNA replication forks. Consequently, cancer cells require multiple enzymes and checkpoint signaling pathways to mitigate replication st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::506647b5f65dd103b501d89edb9f0e26
https://doi.org/10.1158/0008-5472.c.6510099.v1

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Data from Human Postmeiotic Segregation 2 Exhibits Biased Repair at Tetranucleotide Microsatellite Sequences

Autor: Kristin A. Eckert, Sandeep N. Shah

The mismatch repair (MMR) system plays a major role in removing DNA polymerization errors, and loss of this pathway results in hereditary cancers characterized by microsatellite instability. We investigated microsatellite stability during DNA replica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8aa439d583bfe80c6842e590f3ca966e
https://doi.org/10.1158/0008-5472.c.6499356.v1

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Variation in G-quadruplex Sequence and Topology Differentially Impacts Human DNA Polymerase Fidelity

Autor: MaryElizabeth Stein, Suzanne E. Hile, Matthias H. Weissensteiner, Marietta Lee, Sufang Zhang, Eduard Kejnovský, Iva Kejnovská, Kateryna D. Makova, Kristin A. Eckert

Publikováno v: DNA Repair (Amst)

G-quadruplexes (G4s), a type of non-B DNA, play important roles in a wide range of molecular processes, including replication, transcription, and translation. Genome integrity relies on efficient and accurate DNA synthesis, and is compromised by vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a3d1669381473755166e400d871c4e
https://europepmc.org/articles/PMC9798401/

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Distinct sequencing success at non-B-DNA motifs

Autor: Matthias H. Weissensteiner, Marzia A. Cremona, Wilfried Guiblet, Nicholas Stoler, Robert S. Harris, Monika Cechova, Kristin A. Eckert, Francesca Chiaromonte, Yi-Fei Huang, Kateryna D. Makova

Modern sequencing technologies are not error-free, and might have elevated error rates at some locations of the genome. A potential cause for such elevated error rates is the formation of alternative DNA structures (non-B DNA), such as G-quadruplexes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::840e50932a97cad2f3dee5b0659bed7b
https://doi.org/10.1101/2022.06.13.495922

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Special Issue 'DNA Replication/Repair, and the DNA Damage Response in Human Disease'

Autor: Dong Zhang, Kristin A. Eckert, Marietta Y. W. T. Lee

Publikováno v: Genes. 14:893

Mutations of numerous genes involved in DNA replication, DNA repair, and DNA damage response (DDR) pathways lead to a variety of human diseases, including aging and cancer [...]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c025b4029a96250bf88c6b46d0d6636
https://doi.org/10.3390/genes14040893

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Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome

Autor: Kateryna D. Makova, Kristin A. Eckert, Francesca Chiaromonte, Yi-Fei Huang, Wilfried Guiblet, Di Chen, Robert S. Harris, Marzia A. Cremona

Publikováno v: Nucleic Acids Research

Approximately 13% of the human genome can fold into non-canonical (non-B) DNA structures (e.g. G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular processes. Non-B DNA also hinders replication, increasing errors and facilitatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9c29e74579ff0758e313b47ac07527
https://doi.org/10.1093/nar/gkaa1269

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Akademický článek

Microsatellite interruptions stabilize primate genomes and exist as population-specific single nucleotide polymorphisms within individual human genomes.

Autor: Guruprasad Ananda, Suzanne E Hile, Amanda Breski, Yanli Wang, Yogeshwar Kelkar, Kateryna D Makova, Kristin A Eckert

Publikováno v: PLoS Genetics, Vol 10, Iss 7, p e1004498 (2014)

Interruptions of microsatellite sequences impact genome evolution and can alter disease manifestation. However, human polymorphism levels at interrupted microsatellites (iMSs) are not known at a genome-wide scale, and the pathways for gaining interru

Externí odkaz: https://doaj.org/article/a2f12fa98803456895ba38bb9bbebe23

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