CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

Autor: Amanda H. Chan, Nathaniel Huebsch, Mohammad A. Mandegar, Annie Truong, Yuichiro Miyaoka, Ekaterina B. Frolov, Po-Lin So, Tilde Eskildsen, David E. Gordon, Lei S. Qi, Luke A. Gilbert, Kristin Holmes, Søren P. Sheikh, Bruce R. Conklin, Jacqueline E. Villalta, Edward Shin, Luke M. Judge, Jonathan S. Weissman, Nevan J. Krogan, Michael P. Olvera, Max A. Horlbeck, C. Ian Spencer

Publikováno v: Cell stem cell, vol 18, iss 4
Mandegar, M A, Huebsch, N, Frolov, E B, Shin, E, Truong, A, Olvera, M P, Chan, A H, Miyaoka, Y, Holmes, K, Spencer, C I, Judge, L M, Gordon, D E, Eskildsen, T, Villalta, J E, Horlbeck, M A, Gilbert, L A, Krogan, N J, Sheikh, S P, Weissman, J S, Qi, L S, So, P-L & Conklin, B R 2016, ' CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs ', Cell Stem Cell, vol. 18, no. 4, pp. 541-553 . https://doi.org/10.1016/j.stem.2016.01.022

Developing technologies for efficient and scalable disruption of gene expression will provide powerful tools for studying gene function, developmental pathways, and disease mechanisms. Here, we develop clustered regularly interspaced short palindromi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46dc91a30078b38e3cb997fe0327819a
https://doi.org/10.1016/j.stem.2016.01.022

Differences in Physicians’ and Nurses’ Recent Suicide Attempts: An Exploratory Study

Autor: Leo Sher, María Dolores Braquehais, Marta Casanovas, Tània Pujol, Maria Bravo, Pilar Lusilla, Xulián Mozo, Kristin Holmes, Marcela Mezzatesta, Francisco José Eiroa-Orosa

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona

The aim of this study was to examine the characteristics of physicians' and nurses' suicide attempts (SA). A retrospective review of 493 medical records of physicians and nurses admitted to an inpatient unit for health professionals; 36 patients had

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c7bed1b2eb69bfbc1e4c179452c869
https://doi.org/10.1080/13811118.2014.996693

Oscillatory Shear Stress Induces Mitochondrial Superoxide Production: Implication of NADPH Oxidase and c-Jun NH2-Terminal Kinase Signaling

Autor: Tzung K. Hsiai, Rongsong Li, Lisong Ai, Mark L. Barr, Farhad Dharbandi, Nelson Jen, Ryan T. Hamilton, Wakako Takabe, Kristin Holmes, Sky Wang, Bhavraj Khalsa, Steven Bressler

Publikováno v: Antioxidants & Redox Signaling. 15:1379-1388

Fluid shear stress is intimately linked with vascular oxidative stress and atherosclerosis. We posited that atherogenic oscillatory shear stress (OSS) induced mitochondrial superoxide (mtO2•−) production via NADPH oxidase and c-Jun NH2-terminal k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37835c53f781e4820e4aaa38b8bcb665
https://doi.org/10.1089/ars.2010.3645