Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kristin, Mentz"'
Autor:
Paolo Ghia, Heiko Bruns, Martin Böttcher, Junyan Lu, Elisavet Chartomatsidou, Nikos Papakonstantinou, Kristin Mentz, Thorsten Zenz, Marco Herling, Wolfgang Huber
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Emerging data suggest that CLL-cells efficiently evade immunosurveillance. T-cell deficiencies in CLL include immuno(metabolic) exhaustion that is achieved by inhibitory molecu
Externí odkaz:
https://doaj.org/article/c1073d8c7aa847948c61b875fa60cc2d
Autor:
Lukas, Häselbarth, Axel, Karow, Kristin, Mentz, Martin, Böttcher, Oisin, Roche-Lancaster, Manuela, Krumbholz, Regina, Jitschin, Dimitrios, Mougiakakos, Markus, Metzler
Publikováno v:
Cancer Immunology, Immunotherapy. 72:1661-1672
T cell function is central to immune reconstitution and control of residual chronic myeloid leukemia (CML) cells after treatment initiation and is associated with achieving deep molecular response as a prerequisite for treatment-free remission, the u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df2e14101a09e455e48fbac5177b84a
https://doi.org/10.1007/s00262-022-03361-8
https://doi.org/10.1007/s00262-022-03361-8
Autor:
Martin Böttcher, Kathrin Renner, Raffaela Berger, Kristin Mentz, Simone Thomas, Zugey Elizabeth Cardenas-Conejo, Katja Dettmer, Peter J. Oefner, Andreas Mackensen, Marina Kreutz, Dimitrios Mougiakakos
Publikováno v:
OncoImmunology, Vol 7, Iss 7 (2018)
D-2-hydroxyglutarate (D-2HG) is released by various types of malignant cells including acute myeloid leukemia (AML) blasts carrying isocitrate dehydrogenase (IDH) gain-of-function mutations. D-2HG acting as an oncometabolite promotes proliferation, a
Externí odkaz:
https://doaj.org/article/ab18e32d083c474ca4a2ca6973dc1763
Autor:
Wolfgang Huber, Andreas Mackensen, Martin Böttcher, Heiko Bruns, Junyan Lu, Dimitrios Mougiakakos, Thorsten Zenz, Elisavet Chartomatsidou, Maike Büttner-Herold, Kostas Stamatopoulos, Marco Herling, Simon Völkl, Kristin Mentz, Nikos Papakonstantinou, Paolo Ghia
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Emerging data suggest that CLL-cells efficiently evade immunosurveillance. T-cell deficiencies in CLL include immuno(metabolic) exhaustion that is achieved by inhibitory molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd35b50fedbdc830b49291192a2c104
https://jitc.bmj.com/content/9/4/e001889.full
https://jitc.bmj.com/content/9/4/e001889.full
Autor:
Dimitrios Mougiakakos, Marina Kreutz, Peter J. Oefner, Simone Thomas, Martin Böttcher, Kathrin Renner, Zugey Elizabeth Cardenas-Conejo, Andreas Mackensen, Raffaela S. Berger, Katja Dettmer, Kristin Mentz
Publikováno v:
OncoImmunology, Vol 7, Iss 7 (2018)
Oncoimmunology
Oncoimmunology
D-2-hydroxyglutarate (D-2HG) is released by various types of malignant cells including acute myeloid leukemia (AML) blasts carrying isocitrate dehydrogenase (IDH) gain-of-function mutations. D-2HG acting as an oncometabolite promotes proliferation, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732ed7b8d4d70b75a6000e1927d41e83
Autor:
Simon Voelkl, Dimitrios Mougiakakos, Andreas Mackensen, Kristin Mentz, Martin Boettcher, Robert K. Slany, Konstantinos Panagiotidis, Heiko Bruns
Publikováno v:
Blood. 134:2714-2714
Introduction: The bone marrow stromal niche can serve as a protective environment in hematological malignancies such as AML. Intensive research of the bidirectional interactions between leukemic blasts and stromal cells already highlighted numerous m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3776c3bffeaf97830e7db5215d2e06c5
https://doi.org/10.1182/blood-2019-129689
https://doi.org/10.1182/blood-2019-129689
Autor:
Joerg Bruenke, Matthias Peipp, Bernhard Stockmeyer, Christoph Stein, Georg H. Fey, Kristin Mentz, Heike Horner, Joerg Schubert, Michael Schwenkert, Karin Barbin, Christian Kellner
Publikováno v:
Cancer Letters. 303:128-139
Bispecific scFv antibody-derivatives (bsscFvs) recruiting natural killer (NK) cells for the lysis of malignant cells have therapeutic potential. However, a bsscFv specific for the B-lymphoid tumor antigen CD19 and the trigger molecule CD16 on NK cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920624cec7c9e2df3f59b1372b63dd67
https://doi.org/10.1016/j.canlet.2011.01.020
https://doi.org/10.1016/j.canlet.2011.01.020
Autor:
Michael Schwenkert, Christoph Stein, Georg H. Fey, Andreas Mackensen, Fuat Oduncu, Markus Kügler, Kristin Mentz, Bernhard Stockmeyer, Ingo Schubert, Christian Kellner, Heiko Singer, Domenica Saul
Publikováno v:
British Journal of Haematology. 150:574-586
Two trivalent constructs consisting of single-chain Fv antibody fragments (scFvs) specific for the interleukin-3 receptor alpha chain (CD123), CD33 and the Fcgamma-receptor III (CD16) were designed and characterized for the elimination of acute myelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::508f4f01b614ad3fa0197800eb643ee6
https://doi.org/10.1111/j.1365-2141.2010.08300.x
https://doi.org/10.1111/j.1365-2141.2010.08300.x
Autor:
Georg H. Fey, Kristin Mentz, Christian Kellner, Michael Schwemmlein, Christoph Stein, Andreas Mackensen, Bernhard Stockmeyer, Harald Lanig, Heiko Singer, Michael Aigner, Fuat Oduncu
Publikováno v:
Journal of Immunotherapy. 33:599-608
Single-chain Fv triplebodies (sctb), consisting of a single polypeptide chain with 3 single-chain antibody variable fragments connected in tandem, were generated as antileukemic agents. A CD19-specific sctb of this format has previously been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed40a273f994245bfd9ccd9161a417c6
https://doi.org/10.1097/cji.0b013e3181dda225
https://doi.org/10.1097/cji.0b013e3181dda225
Autor:
Christian Kellner, Julia Stieglmaier, Georg H. Fey, Kristin Mentz, Peter Lang, Michael Schwenkert, Michael Schwemmlein, Matthias Peipp, Bernhard Stockmeyer, Fuat Oduncu, Joerg Bruenke, Heiko Singer
Publikováno v:
Journal of Immunotherapy. 31:871-884
A novel bispecific antibody-derived recombinant protein targeting leukemias and lymphomas was designed, a single-chain Fv triple body (sctb) consisting of 1 polypeptide chain with 3 scFvs connected in tandem. The distal scFvs were specific for the tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9d7ae63359bbe4f87b7b5e409e79ed
https://doi.org/10.1097/cji.0b013e318186c8b4
https://doi.org/10.1097/cji.0b013e318186c8b4