A T-cell engaging bispecific antibody with a tumor-selective bivalent folate receptor alpha binding arm for the treatment of ovarian cancer

Autor: Brian C. Avanzino, Kirthana Prabhakar, Pranjali Dalvi, Sharon Hartstein, Hannes Kehm, Aarti Balasubramani, Andrew A. Boudreau, Ben Buelow, Karen Chang, Laura M. Davison, Suhasini Iyer, Vidyut Kalwit, Kristin Lewis Wilson, Harbani K. Malik-Chaudhry, Will Pierson, Geovanni Pineda, Udaya S. Rangaswamy, Sowmya Saiganesh, Ute Schellenberger, Harshad S. Ugamraj, Rodolfovan D. Yabut, Roland Buelow, Jocelyn Chapman, Nathan D. Trinklein, Katherine E. Harris

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

The use of T-cell engagers (TCEs) to treat solid tumors is challenging, and several have been limited by narrow therapeutic windows due to substantial on-target, off-tumor toxicities due to the expression of low levels of target antigens on healthy t

Externí odkaz: https://doaj.org/article/9e96f15bb0a54d7bb137adf3be604c3c

Contributors

Autor: Rick Adler, Famke Aeffner, Laura E. Armstrong, Dmitri Artemov, Adam D. Aulbach, Bindu M. Bennet, Eric A. Blomme, Brad Bolon, Christopher J. Bowman, Molly Boyle, Alys Bradley, Dino Bradley, Danielle Brown, Pierre R. Bushel, Ellen Cannady, Mark F. Cesta, Curtis Chan, Jennifer A. Chilton, Peter J.M. Clements, Torrie A. Crabbs, Myrtle A. Davis, Sandy Eldridge, Daniela Ennulat, Jeffrey Everitt, Isabel Figueroa, James D. Fikes, Thomas Forest, Catherine A. Foss, John R. Foster, Kathleen Gabrielson, Shayne C. Gad, Kapil Gadkar, Jinping Gan, David Garcia-Tapia, Frank J. Geoly, Wendy G. Halpern, Jerry F. Hardisty, Wanda M. Haschek, Kathleen Marie Heinz-Taheny, Kristi Helke, Lauren E. Himmel, Mark J. Hoenerhoff, Jennifer L. Ingram–Ross, Armando R. Irizarry Rovira, Evan B. Janovitz, Kishore Katyayan, Charlotte M. Keenan, Angela King-Herbert, Steven T. Laing, Lois D. Lehman-McKeeman, Na Li, Calvert Louden, Claire Lyons, Kevin McDorman, Elizabeth McInnes, Lyn Miller Wancket, Sheroy Minocherhomji, Sébastien Monette, James Morrison, Vasanthi Mowat, Sydney Mukaratirwa, Keith Nelson, Arun R. Pandiri, Tracey Papenfuss, Nita Patel, Daniel J. Patrick, Shari A. Price, Deepa B. Rao, James T. Raymond, Jennifer Rojko, Colin G. Rousseaux, Sara F. Santagostino, Aaron Sargeant, Christina Satterwhite, A. Eric Schultze, Vanessa Schumacher, Cheryl Scudamore, Keith R. Shockley, Bhanu P. Singh, David M. Stresser, Polina Sysa-Shah, Debra A. Tokarz, Terry Van Vleet, Matthew A. Wallig, Jin Wang, Cynthia J. Willson, Kristin Lewis Wilson, Christopher T. Winkelmann, Jeffrey C. Wolf, Charles Wood, Daniela Bumbaca Yadav, Mark Zarella

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3831ed61c4599a4d47034bfb7e19d99
https://doi.org/10.1016/b978-0-12-821044-4.01002-5

Liver-specific mitochondrial amidoxime-reducing component 1 (Mtarc1) knockdown protects the liver from diet-induced MASH in multiple mouse models.

Autor: Guo Y; Research Biomarkers, Amgen Research, South San Francisco, California, USA., Gao Z; Cardiometabolic Disorders, Amgen Research, South San Francisco, California, USA., LaGory EL; Pharmacokinetics and Drug Metabolism, Amgen Research, South San Francisco, California, USA., Kristin LW; Translational Safety and Bioanalytical Sciences, Amgen Research, South San Francisco, California, USA., Gupte J; Cardiometabolic Disorders, Amgen Research, South San Francisco, California, USA., Gong Y; Cardiometabolic Disorders, Amgen Research, South San Francisco, California, USA., Rardin MJ; Discovery Technology Platforms, Amgen Research, South San Francisco, California, USA., Liu T; Center for Research Acceleration by Digital Innovation, Amgen Research, Cambridge, Massachusetts, USA., Nguyen TT; Center for Research Acceleration by Digital Innovation, Amgen Research, Cambridge, Massachusetts, USA., Long J; RNA Therapeutics, Amgen Research, One Amgen Center Drive, Thousand Oaks, California, USA., Hsu YH; Center for Research Acceleration by Digital Innovation, Amgen Research, Cambridge, Massachusetts, USA., Murray JK; RNA Therapeutics, Amgen Research, One Amgen Center Drive, Thousand Oaks, California, USA., Lade J; Pharmacokinetics and Drug Metabolism, Amgen Research, South San Francisco, California, USA., Jackson S; Cardiometabolic Disorders, Amgen Research, South San Francisco, California, USA., Zhang J; Cardiometabolic Disorders, Amgen Research, South San Francisco, California, USA.

Publikováno v: Hepatology communications [Hepatol Commun] 2024 May 02; Vol. 8 (5). Date of Electronic Publication: 2024 May 02 (Print Publication: 2024).