Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Kristijan, Ramadan"'
Autor:
Samuel Hume, Claudia P. Grou, Pauline Lascaux, Vincenzo D’Angiolella, Arnaud J. Legrand, Kristijan Ramadan, Grigory L. Dianov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Entry into S phase of the cell cycle is regulated positively by mitogens and negatively by DNA damage; however, how balance of these signals is achieved is not well known. Here the authors show that the NUCKS1-SKP2- p21/p27 axis integrates this infor
Externí odkaz:
https://doaj.org/article/bb543b94e36042c6a1671243251e6cf4
Autor:
Juri Na, Joseph A. Newman, Chee Kin Then, Junetha Syed, Iolanda Vendrell, Ignacio Torrecilla, Sophie Ellermann, Kristijan Ramadan, Roman Fischer, Anne E. Kiltie
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-17 (2021)
Abstract The human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses dual 3′−5′ exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously ident
Externí odkaz:
https://doaj.org/article/3103fd513d43413eb4a4915b79d69200
Autor:
Annamaria Ruggiano, Kristijan Ramadan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
DNA–protein crosslink (DPC) proteases digest the protein component of crosslinks that otherwise can cause genomic instability and disease. Ruggiano and Ramadan discuss recent insights into the roles of DPC proteases in the repair of DPCs and beyond
Externí odkaz:
https://doaj.org/article/9bee877057934c8eb531024e1fe21fbc
Autor:
John Fielden, Katherine Wiseman, Ignacio Torrecilla, Shudong Li, Samuel Hume, Shih-Chieh Chiang, Annamaria Ruggiano, Abhay Narayan Singh, Raimundo Freire, Sylvana Hassanieh, Enric Domingo, Iolanda Vendrell, Roman Fischer, Benedikt M. Kessler, Timothy S. Maughan, Sherif F. El-Khamisy, Kristijan Ramadan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. Here, the authors reveal insights into the molecular resolution of topoisomerase 1-DNA adducts by TEX264, p97 and SPRTN.
Externí odkaz:
https://doaj.org/article/8eb6f2f6a3d047b7b8052b86b27f7725
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100978- (2021)
Summary: DNA end resection converts broken ends of double-stranded DNA (dsDNA) to 3′-single-stranded DNA (3′-ssDNA). The extent of resection regulates DNA double-strand break (DSB) repair pathway choice and thereby genomic stability. Here, we cha
Externí odkaz:
https://doaj.org/article/df88efb6bb6f41ffabbd89d98ecc3a22
Autor:
Swagata Halder, Ignacio Torrecilla, Martin D. Burkhalter, Marta Popović, John Fielden, Bruno Vaz, Judith Oehler, Domenic Pilger, Davor Lessel, Katherine Wiseman, Abhay Narayan Singh, Iolanda Vendrell, Roman Fischer, Melanie Philipp, Kristijan Ramadan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Cells deficient in SPRTN protease activity exhibit severe DNA-protein crosslink induced replication stress and genome instability. Here the author reveal a functional link between the SPRTN protease and the CHK1 kinase during physiological DNA replic
Externí odkaz:
https://doaj.org/article/21ed31bb8358406db2dcfaaf5eadcf04
Autor:
Susan Kilgas, Kristijan Ramadan
Publikováno v:
Cell Chemical Biology. 30:3-21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83eeaa0639640ecd2e4e9ac0ad0fd020
https://doi.org/10.1016/j.chembiol.2022.12.007
https://doi.org/10.1016/j.chembiol.2022.12.007
Autor:
Esperanza Hernández-Carralero, Elisa Cabrera, Gara Rodríguez-Torres, Yeray Hernández-Reyes, Abhay N Singh, Cristina Santa-María, José Miguel Fernández-Justel, Roel C Janssens, Jurgen A Marteijn, Bernd O Evert, Niels Mailand, María Gómez, Kristijan Ramadan, Veronique A J Smits, Raimundo Freire
Publikováno v:
Hernández-Carralero, E, Cabrera, E, Rodríguez-Torres, G, Hernández-Reyes, Y, Singh, A N, Santa-María, C, Fernández-Justel, J M, Janssens, R C, Marteijn, J A, Evert, B O, Mailand, N, Gómez, M, Ramadan, K, Smits, V A J & Freire, R 2023, ' ATXN3 controls DNA replication and transcription by regulating chromatin structure ', Nucleic Acids Research, vol. 51, no. 11, pp. 5396–5413 . https://doi.org/10.1093/nar/gkad212
The deubiquitinating enzyme Ataxin-3 (ATXN3) contains a polyglutamine (PolyQ) region, the expansion of which causes spinocerebellar ataxia type-3 (SCA3). ATXN3 has multiple functions, such as regulating transcription or controlling genomic stability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5aa7d5c4a33687a0e2797bef5f2c754
https://doi.org/10.1093/nar/gkad212
https://doi.org/10.1093/nar/gkad212
Autor:
André Franz, Paul A. Pirson, Domenic Pilger, Swagata Halder, Divya Achuthankutty, Hamid Kashkar, Kristijan Ramadan, Thorsten Hoppe
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Cdc48/p97 is a key component of the ubiquitin-proteasome system, acting as a ubiquitin-directed segregase to regulate multiple cellular functions. Here the authors identify UBXN-3/FAF1 as a crucial regulator of chromatin-associated protein degradatio
Externí odkaz:
https://doaj.org/article/686b5c06127b4ab8a306f8fad9fed186
Autor:
James Chettle, Zinaida Dedeic, Roman Fischer, Iolanda Vendrell, Leticia Campo, Alistair Easton, Molly Browne, Josephine Morris, Hagen Schwenzer, Pauline Lascaux, Rik Gijsbers, Elisabete Pires, Daniel J. Royston, David J. P. Ferguson, An Coosemans, Benedikt Kessler, James McCullagh, Ahmed A. Ahmed, Kristijan Ramadan, Martin Bushell, Adrian L. Harris, Colin R. Goding, Sarah P. Blagden
The protein mammalian target of rapamycin (mTOR) is a master regulator of cell homeostasis. Although mTOR is aberrantly overactivated in 70% ovarian cancers, mTOR cascade inhibitors (such as those blocking the kinase activity of mTOR itself or upstre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d8462c75f390518b2b821ba0393ad55
https://doi.org/10.1101/2022.09.04.506559
https://doi.org/10.1101/2022.09.04.506559
