Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Kristiina M, Huttunen"'
Autor:
Agathe Hugele, Susanne Löffler, Belén Hernández Molina, Melina Guillon, Ahmed B. Montaser, Seppo Auriola, Kristiina M. Huttunen
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
A prodrug approach is a powerful method to temporarily change the physicochemical and thus, pharmacokinetic properties of drugs. However, in site-selective targeted prodrug delivery, tissue or cell-specific bioconverting enzyme is needed to be utiliz
Externí odkaz:
https://doaj.org/article/cce3d5a18df2438abe6395b679fabb6b
Publikováno v:
CHIMIA, Vol 76, Iss 5 (2022)
The expression of membrane transporter is often altered in cancer cells compared to their corresponding healthy cells. Since these proteins, classified into solute carriers (SLCs) and ATP-binding cassettes (ABCs), can carry not only endogenous compou
Externí odkaz:
https://doaj.org/article/5d6a9c538d0c483a9bad69c86e3becf7
Autor:
Arun Kumar Tonduru, Santosh Kumar Adla, Kristiina M. Huttunen, Thales Kronenberger, Antti Poso
Publikováno v:
Molecules, Vol 27, Iss 23, p 8531 (2022)
To better understand the functionality of organic anion transporting polypeptides (OATPs) and to design new ligands, reliable structural data of each OATP is needed. In this work, we used a combination of homology model with molecular dynamics simula
Externí odkaz:
https://doaj.org/article/b5627aceaa3e45db95d73e319836e7d6
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1234 (2022)
Membrane transporters have a crucial role in compounds’ brain drug delivery. They allow not only the penetration of a wide variety of different compounds to cross the endothelial cells of the blood–brain barrier (BBB), but also the accumulation o
Externí odkaz:
https://doaj.org/article/2d786106ae254fe3805260edccb678c3
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4132 (2022)
Due to its high efficiency, good safety profile, and potential cardio-protective properties, metformin, a dimethyl biguanide, is the first-line medication in antihyperglycemic treatment for type 2 diabetic patients. The aim of our present study was t
Externí odkaz:
https://doaj.org/article/785e3e91f77f4adca4469ce07d198138
Autor:
Johanna Huttunen, Thales Kronenberger, Ahmed B. Montaser, Adéla Králová, Tetsuya Terasaki, Antti Poso, Kristiina M. Huttunen
Publikováno v:
Molecular Pharmaceutics. 20:1331-1346
Autor:
Katayun Bahrami, Juulia Järvinen, Tuomo Laitinen, Mika Reinisalo, Paavo Honkakoski, Antti Poso, Kristiina M. Huttunen, Jarkko Rautio
Publikováno v:
Molecular Pharmaceutics. 20:206-218
L-type amino acid transporter 1 (LAT1) transfers essential amino acids across cell membranes. Owing to its predominant expression in the blood-brain barrier and tumor cells, LAT1 has been exploited for drug delivery and targeting to the central nervo
Autor:
Julie A. Spicer, Kristiina M. Huttunen, Jiney Jose, Ivo Dimitrov, Hedieh Akhlaghi, Vivien R. Sutton, Ilia Voskoboinik, Joseph Trapani
Publikováno v:
Journal of Medicinal Chemistry. 65:14305-14325
New drugs that precisely target the immune mechanisms critical for cytotoxic T lymphocyte (CTL) and natural killer (NK) cell driven pathologies are desperately needed. In this perspective, we explore the cytolytic protein perforin as a target for the
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1309-1322 (2018)
The aim of this study was to assess in vitro the effects of sulphenamide and sulphonamide derivatives of metformin on the activity of human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), establish the type of inhibition, and assess th
Externí odkaz:
https://doaj.org/article/6621bf7a7b6547f18d1d1f19b4ce9b86
Publikováno v:
Molecules, Vol 27, Iss 1, p 37 (2021)
l-Type amino acid transporter 1 (LAT1), expressed abundantly in the brain and placenta and overexpressed in several cancer cell types, has gained a lot of interest in drug research and development, as it can be utilized for brain-targeted drug delive
Externí odkaz:
https://doaj.org/article/473ae7aa14484bb48954d43639de5632