Výsledky vyhledávání - "Kristien J M Zaal"

Akademický článek

Who needs microtubules? Myogenic reorganization of MTOC, Golgi complex and ER exit sites persists despite lack of normal microtubule tracks.

Autor: Kristien J M Zaal, Ericka Reid, Kambiz Mousavi, Tan Zhang, Amisha Mehta, Elisabeth Bugnard, Vittorio Sartorelli, Evelyn Ralston

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e29057 (2011)

A wave of structural reorganization involving centrosomes, microtubules, Golgi complex and ER exit sites takes place early during skeletal muscle differentiation and completely remodels the secretory pathway. The mechanism of these changes and their

Externí odkaz: https://doaj.org/article/7db8bde66d874ac5a42f5c01bfc7f9f2

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Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Autor: Natasha Silke, Manfred Boehm, Amanda K. Ombrello, Ivona Aksentijevich, Deborah L. Stone, Tina Romeo, Marco J Herold, Laurens Wachsmuth, Christine Biben, Beverly K. Barham, Lin Liu, Andrew J. Gross, Sergio D. Rosenzweig, Patrycja Hoffmann, Natalia Sampaio Moura, Gustavo Gutierrez-Cruz, Daniel L. Kastner, Steven E. Boyden, Kristien J. M. Zaal, Anne K. Voss, Holly Anderton, Anne Jones, Hongying Wang, Tobias Kratina, John Silke, Michael J. Lenardo, James C. Mullikin, Kate E. Lawlor, David B. Beck, Mark D. McKenzie, Amanda Light, Anthony K. Shum, Jae Jin Chae, Massimo Gadina, Qing Zhou, Diep Chau, Gineth Pinto-Patarroyo, Hirotsugu Oda, Geryl Wood, Mary Blake, Nima Etemadi, Kristy Shield-Artin, Edwin D. Hawkins, Monique Stoffels, Cathrine Hall, Dan Yang, Wanxia Li Tsai, Hye Sun Kuehn, Natalia I. Dmitrieva, Seth L. Masters, Lixin Zheng, Andrew J. Kueh, Manolis Pasparakis, Najoua Lalaoui

Publikováno v: Nature
Nature, vol 577, iss 7788

Receptor Interacting Protein Kinase 1 (RIPK1) is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is post-translationally regulated by well characterised ubiquitylation and phosphorylation events

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a3bb64e2ed7e5ed42a46b65bfc0fb6
https://doi.org/10.1038/s41586-019-1828-5

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β-Actin shows limited mobility and is required only for supraphysiological insulin-stimulated glucose transport in young adult soleus muscle

Autor: Peter Schjerling, Thomas E. Jensen, Jonas R. Knudsen, Evelyn Ralston, Agnete B. Madsen, Lykke Sylow, Carlos Henríquez-Olguín, Yeliz Angin, Kristien J. M. Zaal

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 315:E110-E125

Studies in skeletal muscle cell cultures suggest that the cortical actin cytoskeleton is a major requirement for insulin-stimulated glucose transport, implicating the β-actin isoform, which in many cell types is the main actin isoform. However, it i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b90392268cb0a605c93e93bfe977ed
https://doi.org/10.1152/ajpendo.00392.2017

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mGluR5 mediates post-radiotherapy fatigue development in cancer patients

Autor: Enrique J. deAndrés-Galiana, Brian S. Wolff, Leorey N. Saligan, Kristien J. M. Zaal, Li Rebekah Feng, Juan Luis Fernández-Martínez

Publikováno v: Translational Psychiatry, Vol 8, Iss 1, Pp 1-11 (2018)
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Translational Psychiatry

Cancer-related fatigue (CRF) is a common burden in cancer patients and little is known about its underlying mechanism. The primary aim of this study was to identify gene signatures predictive of post-radiotherapy fatigue in prostate cancer patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f980ed80cc57751181a9ee3414f3cce9
http://link.springer.com/article/10.1038/s41398-018-0161-3

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Misplaced Golgi Elements Produce Randomly Oriented Microtubules and Aberrant Cortical Arrays of Microtubules in Dystrophic Skeletal Muscle Fibers

Autor: Evelyn Ralston, Davide Randazzo, Aster Kenea, Bruno Alonso, Kristien J. M. Zaal, Sarah Oddoux

Publikováno v: Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 7 (2019)

Differentiated mammalian cells and tissues, such as skeletal muscle fibers, acquire an organization of Golgi complex and microtubules profoundly different from that in proliferating cells and still poorly understood. In adult rodent skeletal muscle,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6712c77bd96caedda20a297d1b8a4206
https://doi.org/10.3389/fcell.2019.00176

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Persistent upregulation of the β-tubulin tubb6, linked to muscle regeneration, is a source of microtubule disorganization in dystrophic muscle

Autor: John T. Olthoff, Aster Kenea, Andrew L. Mammen, Umara Khalique, Davide Randazzo, Michelle D Tran, Katherine Pak, Dan L. Sackett, James M. Ervasti, Evelyn Ralston, Joseph J. Belanto, Dana M Talsness, Iago Pinal-Fernandez, Kristien J. M. Zaal

Publikováno v: Human molecular genetics. 28(7)

In healthy adult skeletal muscle fibers microtubules form a three-dimensional grid-like network. In the mdx mouse, a model of Duchenne muscular dystrophy (DMD), microtubules are mostly disordered, without periodicity. These microtubule defects have b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88aa20817f31765b6c6b73c727c89a1d
https://pubmed.ncbi.nlm.nih.gov/30753428

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AB0024 A novel real-time imaging technique to characterize mechanisms of cell death in neutrophils

Autor: E Ralston, Kristien J. M. Zaal, Mariana J. Kaplan, DW Chan, Sarthak Gupta

Publikováno v: Abstracts Accepted for Publication.

Background Neutrophils play a key role in the pathogenesis of autoimmune diseases through various mechanisms including the formation of neutrophil extracellular traps (NETs). NETosis, a recently described distinct form of program neutrophil cell deat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e68bd1b903185508626d707bd2696af
https://doi.org/10.1136/annrheumdis-2017-eular.3593

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Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model

Autor: Michael W. McBurney, Xiao Hong He, Kristien J. M. Zaal, Mona Dvir-Ginzberg, Christelle Sanchez, Viktoria Gagarina, Odile Gabay, Yingjie Song

Publikováno v: Arthritis & Rheumatism. 65:159-166

Osteoarthritis (OA) is a multifactorial and complex degenerative disease of the cartilage. Different mechanisms are involved in cartilage degradation, including inflammation, apoptosis, and breakdown of major extracellular matrix (ECM) components, su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea308558260122b853b338a3f5f68e1
https://doi.org/10.1002/art.37750

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Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice

Autor: Christelle Sanchez, Kristien J. M. Zaal, Mona Dvir-Ginzberg, H. Meir, Hanna Oppenhiemer, Odile Gabay

Publikováno v: Annals of the Rheumatic Diseases. 71:613-616

Objective A growing body of evidence indicates that the protein deacetylase, SirT1, affects chondrocyte biology and survival. This report aims to evaluate in vivo attributes of SirT1 in cartilage biology of 129/J murine strains. Methods Heterozygous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3103b3a906c9621116644215e7d4c895
https://doi.org/10.1136/ard.2011.200504

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