Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Kristie L. Rose"'
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
IntroductionProtein post-translational modifications (PTMs) have been associated with aging and age-related diseases. PTMs are particularly impactful in long-lived proteins, such as those found in the ocular lens, because they accumulate with age. Tw
Externí odkaz:
https://doaj.org/article/accaec59125a4e678ff099cf32133487
Autor:
Eloy Bejarano, Elizabeth A. Whitcomb, Rebecca L. Pfeiffer, Kristie L. Rose, Maria José Asensio, José Antonio Rodríguez-Navarro, Alejandro Ponce-Mora, Antolín Canto, Inma Almansa, Kevin L. Schey, Bryan W. Jones, Allen Taylor, Sheldon Rowan
Publikováno v:
Redox Biology, Vol 66, Iss , Pp 102869- (2023)
The lens proteome undergoes dramatic composition changes during development and maturation. A defective developmental process leads to congenital cataracts that account for about 30% of cases of childhood blindness. Gene mutations are associated with
Externí odkaz:
https://doaj.org/article/c11db368416d4869b614ebeb6daca586
Publikováno v:
BBA Advances, Vol 3, Iss , Pp 100079- (2023)
Accumulation of advanced glycation end products (AGEs), particularly in long-lived extracellular matrix proteins, has been implicated in pathogenesis of diabetic complications and in aging. Knowledge about specific locations of AGEs and their precurs
Externí odkaz:
https://doaj.org/article/a1a76c6c18c242e9b7106fb87f251d94
Autor:
Yvonne L. Latour, Johanna C. Sierra, Jordan L. Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Thaddeus M. Smith, Kara M. McNamara, Paula B. Luis, Claus Schneider, Justin Jacobse, Jeremy A. Goettel, M. Wade Calcutt, Kristie L. Rose, Kevin L. Schey, Ginger L. Milne, Alberto G. Delgado, M. Blanca Piazuelo, Bindu D. Paul, Solomon H. Snyder, Alain P. Gobert, Keith T. Wilson
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world’s population and causes gastric cancer. Recent studies have highlighted the importance of macrophage imm
Externí odkaz:
https://doaj.org/article/19c8a2f445654133870ff2cc83d6103c
Publikováno v:
Cells, Vol 11, Iss 24, p 4042 (2022)
Age-related protein truncation is a common process in long-lived proteins such as proteins found in the ocular lens. Major truncation products have been reported for soluble and membrane proteins of the lens, including small peptides that can acceler
Externí odkaz:
https://doaj.org/article/c46b74946ace4d03beb30e20a7bc6873
Autor:
Alain P. Gobert, Jordan L. Finley, Yvonne L. Latour, Mohammad Asim, Thaddeus M. Smith, Thomas G. Verriere, Daniel P. Barry, Margaret M. Allaman, Alberto G. Delagado, Kristie L. Rose, M. Wade Calcutt, Kevin L. Schey, Johanna C. Sierra, M. Blanca Piazuelo, Raghavendra G. Mirmira, Keith T. Wilson
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108510- (2020)
Summary: Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation fa
Externí odkaz:
https://doaj.org/article/c676099b79ac40018987909502fd92db
Autor:
Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Altered serotonin (5-HT) signaling is associated with multiple brain disorders, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and autism spectrum disorder (ASD). The presynaptic, high-affinity 5-HT transporter (SERT)
Externí odkaz:
https://doaj.org/article/229a00d78e494ae49ab6705f21b72c23
Autor:
Clara Chivasso, Carl Johan Hagströmer, Kristie L. Rose, Florent Lhotellerie, Lionel Leblanc, Zhen Wang, Stefania Moscato, Clément Chevalier, Egor Zindy, Maud Martin, Benoit Vanhollebeke, Françoise Gregoire, Nargis Bolaky, Jason Perret, Chiara Baldini, Muhammad Shahnawaz Soyfoo, Letizia Mattii, Kevin L. Schey, Susanna Törnroth-Horsefield, Christine Delporte
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9213 (2021)
Sjögren’s syndrome (SS) is an exocrinopathy characterized by the hypofunction of salivary glands (SGs). Aquaporin-5 (AQP5); a water channel involved in saliva formation; is aberrantly distributed in SS SG acini and contributes to glandular dysfunc
Externí odkaz:
https://doaj.org/article/ca70385e45674e72b09e281d174bd38f
Autor:
Andrew C. Hiday, Michael C. Edler, Asma B. Salek, Cameron W. Morris, Morrent Thang, Tyler J. Rentz, Kristie L. Rose, Lisa M. Jones, Anthony J. Baucum
Publikováno v:
Neural Plasticity, Vol 2017 (2017)
Signaling changes that occur in the striatum following the loss of dopamine neurons in the Parkinson disease (PD) are poorly understood. While increases in the activity of kinases and decreases in the activity of phosphatases have been observed, the
Externí odkaz:
https://doaj.org/article/0595cece42914d5e8f3e7147b23346a2
Autor:
Yahua Zhang, Fabian Bock, Mohammed Ferdaus, Juan Pablo Arroyo, Kristie L Rose, Purvi Patel, Jerod S. Denton, Eric Delpire, Alan M. Weinstein, Ming-Zhi Zhang, Raymond C. Harris, Andrew S. Terker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The renal epithelium is sensitive to changes in blood potassium (K+). We identify the basolateral K+ channel, Kir4.2, as a mediator of the proximal tubule response to K+ deficiency. Mice lacking Kir4.2 have a compensated baseline phenotype w
Externí odkaz:
https://doaj.org/article/466eefddbfcf433986c90e461a6b9ab4