Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kristie L. Connolly"'
Autor:
Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, Kristie L. Connolly, Pooja Srinivas, Matthew C. Torhan, John N. Alumasa, Mynthia Cabrera, Divya Hosangadi, Jay S. Barbor, Steven C. Cardinale, Steven M. Kwasny, Lucas R. Morin, Michelle M. Butler, Timothy J. Opperman, Terry L. Bowlin, Ann Jerse, Scott M. Stagg, Christine M. Dunham, Kenneth C. Keiler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Antibiotic-resistant bacterial pathogens pose a substantial threat to human health. Here, aided by structural analyses, the authors describe the molecular mechanism behind the activity of a series of compounds that inhibit trans-translation and are e
Externí odkaz:
https://doaj.org/article/65f0e506e42e4cd09c551a4db2d7e630
Autor:
Shaochun Chen, Kristie L. Connolly, Corinne Rouquette-Loughlin, Alexander D’Andrea, Ann E. Jerse, William M. Shafer
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Neisseria gonorrhoeae has developed resistance to every antibiotic introduced for treatment of gonorrhea since 1938, and concern now exists that gonorrheal infections may become refractory to all available antibiotics approved for therapy. T
Externí odkaz:
https://doaj.org/article/9ae04b887f90467b992a0deffeba228d
Autor:
Andrew N. Macintyre, Gregory D. Sempowski, Kristie L. Connolly, Ann E. Jerse, Allison C Costenoble-Caherty, Michelle Pilligua-Lucas, Knashka Underwood, Anthony Soc, Carolina Gomez
Publikováno v:
J Infect Dis
Murine models of Neisseria gonorrhoeae lower reproductive tract infection are valuable systems for studying N. gonorrhoeae adaptation to the female host and immune responses to infection. These models have also accelerated preclinical testing of cand
Autor:
Steven Park, Riccardo Russo, Landon Westfall, Riju Shrestha, Matthew Zimmerman, Veronique Dartois, Natalia Kurepina, Barry Kreiswirth, Eric Singleton, Shao-Gang Li, Nisha Mittal, Yong-Mo Ahn, Joseph Bilotta, Kristie L. Connolly, Ann E. Jerse, Joel S. Freundlich, David S. Perlin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
Drug-resistant Neisseria gonorrhoeae is a serious global health concern. New drugs are needed that can overcome existing drug resistance and limit the development of new resistances.
Autor:
Jonathan M. Turner, Ann E. Jerse, Avinash Singh, Robert A. Nicholas, Kate E. Aberman, Christopher Davies, Joseph C. Fonseca, Kristie L. Connolly
Publikováno v:
ACS Infect Dis
The increasing prevalence of Neisseria gonorrhoeae strains exhibiting decreased susceptibility to extended-spectrum cephalosporins (ESCs) presents a challenge for the successful treatment of gonorrhea infections. To address this challenge, we evaluat
Autor:
John O'Donnell, Peter Warn, Ann E. Jerse, Emilie Alirol, George L. Drusano, Francois Franceschi, Brian J. Werth, Brian VanScoy, Françoise Van Bambeke, Magnus Unemo, Prabha Fernandes, Kristie L. Connolly, Edward W. Hook, Lindley A. Barbee, Ursula Theuretzbacher
Publikováno v:
Clinical Microbiology and Infection, Vol. 26, no.12, p. 1630-1635 (2020)
Background Increasing multidrug resistance rates in Neisseria gonorrhoeae have raised concerns and an urgent call for new antibiotics for treatment of gonorrhoea. Several decades of subdued drug development in this field and the recent failures of tw
Autor:
Andrew N. Macintyre, Kristie L. Connolly, Gregory D. Sempowski, Afrin A. Begum, Ann E. Jerse, Kathryn A. Matthias, Margaret C. Bash
Publikováno v:
J Infect Dis
Background Despite decades of research efforts, development of a gonorrhea vaccine has remained elusive. Epidemiological studies suggest that detoxified outer membrane vesicle (dOMV) vaccines from Neisseria meningitidis (Nm) may protect against infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b20942ab78bfd400f97c70de2118d8
https://europepmc.org/articles/PMC8844591/
https://europepmc.org/articles/PMC8844591/
Autor:
Atousa Mehrani, Mynthia Cabrera, Kenneth C. Keiler, Michelle M. Butler, Steven M. Kwasny, Pooja Srinivas, Lucas R. Morin, Divya Hosangadi, John N. Alumasa, Jay S. Barbor, Steven C. Cardinale, Scott M. Stagg, Zachary D. Aron, Christine M. Dunham, Ann E. Jerse, Matthew C. Torhan, Timothy J. Opperman, Eric D. Hoffer, Terry L. Bowlin, Kristie L. Connolly
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Bacterial ribosome rescue pathways that remove ribosomes stalled on mRNAs during translation have been proposed as novel antibiotic targets because they are essential in bacteria and are not conserved in humans. We previously reported the discovery o
Autor:
Divya Hosangadi, Lucas R. Morin, Kristie L. Connolly, Terry L. Bowlin, Michelle M. Butler, Christine M. Dunham, Atousa Mehrani, Zachary D. Aron, Jay S. Barbor, John N. Alumasa, Pooja Srinivas, Kenneth C. Keiler, Eric D. Hoffer, Mynthia Cabrera, Matthew C. Torhan, Scott M. Stagg, Steven M. Kwasny, Timothy J. Opperman, Ann E. Jerse, Steven C. Cardinale
The trans-translation pathway for rescuing stalled ribosomes is conserved and essential in bacterial pathogens but has no mammalian homolog, making it an ideal target for new antibiotics. We previously reported the discovery of a family of acylaminoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c60f516b4139e9bac172634fa60d14b
https://doi.org/10.1101/2020.06.04.132530
https://doi.org/10.1101/2020.06.04.132530
Autor:
Jacqueline T. Balthazar, Kristie L. Connolly, Isabelle Leduc, Nazia Rahman, Stephen C. Darnell, Gregory D. Sempowski, Andrew N. Macintyre, William M. Shafer, Knashka Underwood, Afrin A. Begum, Ann E. Jerse
There is a pressing need for a gonorrhea vaccine due to the high disease burden associated with gonococcal infections globally and the rapid evolution of antibiotic resistance in Neisseria gonorrhoeae (Ng). Current gonorrhea vaccine research is in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6620d11bac03912c0a99a133e6aa4624
https://doi.org/10.1101/2020.05.13.094177
https://doi.org/10.1101/2020.05.13.094177