Výsledky vyhledávání - "Kristie Gehlhaus"

Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening

Autor: Kristie Gehlhaus, Natasha J. Caplen, Jason J. Pitt, Jennifer L Dine, Magdalena Grandin, Sirisha Chakka, Stanley Lipkowitz, Sireesha V. Garimella, Marion M. Nau

Publikováno v: Breast Cancer Research : BCR

Introduction Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to its receptors, TRAIL-receptor 1 (TRAIL-R1) and TRAIL-receptor 2 (TRAIL-R2), leading to apoptosis by activation of caspase-8 and the downstream executioner caspases,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c85854459a48eefb0a5f879f1a7e9e8
https://doi.org/10.1186/bcr3645

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Abstract 15: gp78 is a negative regulator of TRAIL-induced apoptosis in breast cancer cells

Autor: Kristie Gehlhaus, Jennifer L Dine, Natasha J. Caplen, Magda Grandin, Daniel Letwin, Sireesha V. Garimella, Stanley Lipkowitz

Publikováno v: Cancer Research. 75:15-15

TNF-related apoptosis inducing ligand (TRAIL) selectively induces apoptosis in transformed cells by activating the extrinsic apoptotic pathway via its cognate receptors on the cell surface, TRAIL receptor 1 and TRAIL receptor 2. Triple negative breas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2791fd39b7b4d0a1c752da3297d45e21
https://doi.org/10.1158/1538-7445.am2015-15

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Abstract 5124: Identification and characterization of novel regulators of TRAIL-induced apoptosis in breast cancer cells

Autor: Natasha J. Caplen, Magda Grandin, Stanley Lipkowitz, Sireesha V. Garimella, Jennifer L Dine, Kristie Gehlhaus

Publikováno v: Cancer Research. 74:5124-5124

TNF-related apoptosis inducing ligand (TRAIL) is a member of the tumor necrosis factor super family and can induce apoptotic cell death upon binding to its cognate receptors, TRAIL Receptor 1 (TRAIL-R1) and TRAIL Receptor 2 (TRAIL-R2). TRAIL has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9f0a1d515c366f00537583d70dfa4bb
https://doi.org/10.1158/1538-7445.am2014-5124

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Abstract 4106: A functional genomic approach to identify novel molecular regulators of the TRAIL pathway in breast cancer

Autor: Stanley Lipkowitz, Sireesha V. Garimella, Natasha J. Caplen, Magda Grandin, Kristie Gehlhaus

Publikováno v: Cancer Research. 71:4106-4106

Tumor Necrosis Factor (TNF)-Related Apoptosis Inducing Ligand (TRAIL) is a member of the TNF family. The ligand binds to its receptors TRAIL-R1 or TRAIL-R2 leading to formation of the death-inducing signaling complex (DISC) which cleaves the initiato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27de041ed0985bca96da48d44d552486
https://doi.org/10.1158/1538-7445.am2011-4106

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