Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kristie D. Goughenour"'
Autor:
Jintao Xu, Rylan Hissong, Rachel Bareis, Arianna Creech, Kristie D. Goughenour, Christine M. Freeman, Michal A. Olszewski
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT While type I conventional dendritic cells (cDC1s) are vital for generating adaptive immunity against intracellular pathogens and tumors, their role in defense against fungal pathogen Cryptococcus neoformans remains unclear. We investigated t
Externí odkaz:
https://doaj.org/article/6261ad061a554032a966cbdabd266d27
Publikováno v:
Journal of Fungi, Vol 9, Iss 11, p 1050 (2023)
Fungal infections are an increasingly growing public health concern, and Cryptococcus is one of the most problematic fungal organisms causing substantial mortality and morbidity worldwide. Clinically, this high incidence of cryptococcosis is most com
Externí odkaz:
https://doaj.org/article/2c2882b8a75048399f32d1ca551a4e44
Autor:
Piotr R. Stempinski, Kristie D. Goughenour, Lukas M. du Plooy, J. Andrew Alspaugh, Michal A. Olszewski, Lukasz Kozubowski
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Cryptococcus neoformans, an opportunistic yeast pathogen, relies on a complex network of stress response pathways that allow for proliferation in the host. In Saccharomyces cerevisiae, stress responses are regulated by integral membrane prot
Externí odkaz:
https://doaj.org/article/fd20021cafc74f399d55030b8075a0b0
Autor:
Andrew L. Garfoot, Kristie D. Goughenour, Marcel Wüthrich, Murugesan V. S. Rajaram, Larry S. Schlesinger, Bruce S. Klein, Chad A. Rappleye
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT The ability to grow at mammalian body temperatures is critical for pathogen infection of humans. For the thermally dimorphic fungal pathogen Histoplasma capsulatum, elevated temperature is required for differentiation of mycelia or conidia i
Externí odkaz:
https://doaj.org/article/5c09d23e88e94f35870097fd644ba235
Autor:
Ziyin P Zhao, Kristie D Goughenour, Anutosh Ganguly, Michal A. Olszewski, Christine M. Freeman, Jintao Xu, Jessica Zhao
Publikováno v:
The Journal of Immunology. 207:2096-2106
Disseminated cryptococcosis has a nearly 70% mortality, mostly attributed to CNS infection, with lesser-known effects on other organs. Immune protection against Cryptococcus relies on Th1 immunity with M1 polarization, rendering macrophages fungicida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad4dbbcc8da5842634c91ea3d6253883
https://doi.org/10.4049/jimmunol.2100386
https://doi.org/10.4049/jimmunol.2100386
Publikováno v:
Molecular Biology and Evolution
Chitinases enzymatically hydrolyze chitin, a highly abundant and utilized polymer of N-acetyl-glucosamine. Fungi are a rich source of chitinases; however, the phylogenetic and functional diversity of fungal chitinases are not well understood. We surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca076e46254365f8b4e64ebdabce98ec
https://doi.org/10.1093/molbev/msaa293
https://doi.org/10.1093/molbev/msaa293
Chitinases enzymatically hydrolyze chitin, a highly abundant biomolecule with many potential industrial and medical uses in addition to their natural biological roles. Fungi are a rich source of chitinases, however the phylogenetic and functional div
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b0578212dac43d33a14e43999a3d992
https://doi.org/10.1101/2020.06.09.137125
https://doi.org/10.1101/2020.06.09.137125
Autor:
Choon Yong Tan, Chad A. Rappleye, Gerardo D. Anaya-Eugenio, A. Douglas Kinghorn, Richard W. Spjut, Judith C. Gallucci, Fengrui Wang, L. Harinantenaina Rakotondraibe, Esperanza J. Carcache de Blanco, Kristie D. Goughenour
Publikováno v:
J Nat Prod
Four new metabolites, 4-epi-citreoviridin (1), auransterol (3), and two analogues (2 and 4) of paxisterol (6), together with two known metabolites (15R*,20S*)-dihydroxyepisterol (5) and (6), were isolated from cultures of the fungal associate, Penici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83736711390a9be601bf0e8a5b452a3d
https://europepmc.org/articles/PMC6858793/
https://europepmc.org/articles/PMC6858793/
Autor:
Kristie D Goughenour, Jessica Zhao, Jintao Xu, Peter Zhao, Christine Freeman, Anutosh Ganguly, Michal A Olszewski
Publikováno v:
The Journal of Immunology. 206:16.30-16.30
C. neoformans, is one of the top 3 fungal pathogens, causing disseminated disease with high mortality in the absence of immunoprotecion. The protective Th1 immune response leads to M1 macrophage polarization that upregulates inducible nitric oxide sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97fe7d4dd7f31d76e6f4b16ef98a9c81
https://doi.org/10.4049/jimmunol.206.supp.16.30
https://doi.org/10.4049/jimmunol.206.supp.16.30
Autor:
Jacob William Shelton Martens, Jintao Xu, Kristie D Goughenour, Harini Subbiah, Doyun L. Kwak, Brian L. Parkin, Michal A Olszewski
Publikováno v:
The Journal of Immunology. 206:99.31-99.31
Cryptococcal meningoencephalitis (CM) is the major cause of infectious neurological death worldwide, mainly affecting immunocompromised patients. CNS damage is often linked to aberrant inflammatory responses following infection. Deletion of CXCR3 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::482a46c1d8c323d7da5c020fc16008e4
https://doi.org/10.4049/jimmunol.206.supp.99.31
https://doi.org/10.4049/jimmunol.206.supp.99.31