Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kristie A. Faust"'
Autor:
Stephen E. de Laszlo, Raymond S. Chang, Tsing-Bau Chen, Kristie A. Faust, William J. Greenlee, Salah D. Kivlighn, Victor J. Lotti, Stacey S. O'Malley, Terry W. Schorn, Peter K. Siegl, Jennifer Tran, Gloria J. Zingaro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1359-1364
Modification of the 6-N-alkyl-N-acyl groups of L-159,689, 6 6-(N-benzoyl-N-pentyl)-amino-2-propyl-3-[(2′-(tetrazol-5-yl)biphen-4-yl)methyl]quinazolin-4-(3H)one led to the identification of the 6-(N-benzoyl-N-(3-pyridylmethyl)) analog (L-162,537). L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0a634555cb07627e9316d3c58e22ecc
https://doi.org/10.1016/0960-894x(95)00224-h
https://doi.org/10.1016/0960-894x(95)00224-h
Autor:
Peter K. S. Siegl, Salah D. Kivlighn, Gloria J. Zingaro, Tsing-Bau Chen, Kristie A. Faust, Victor J. Lotti, William J. Greenlee, Arthur A. Patchett, Thomas F. Walsh, Kenneth J. Fitch, Raymond S.L. Chang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1151-1154
Directed synthesis and pharmacological evaluation in a recently described class of α-phenoxyphenylacetic acid bearing angiotensin II (AII) receptor antagonists has afforded further potent AT 1 -selective AII antagonists. Substitution in the central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ac6208c532d72a61e408771fa3545d7
https://doi.org/10.1016/0960-894x(95)00185-v
https://doi.org/10.1016/0960-894x(95)00185-v
Autor:
Salah D. Kivlighn, Kenneth J. Fitch, W.J. Greenlee, T. F. Walsh, Peter K. S. Siegl, R. S. L. Chang, Kristie A. Faust, Arthur A. Patchett, Tsing-Bau Chen, Victor J. Lotti, Gloria J. Zingaro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:155-158
A series of nonpeptidic AT1 selective angiotensin II (AII) antagonists containing a phenoxyphenylacetic acid element as a biphenyl tetrazole replacement have been identified. This series yielded compound 20 which exhibited binding affinities of AT1 =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fdc507efde0eace8587fa3c1b7d5d9e
https://doi.org/10.1016/0960-894x(94)00476-v
https://doi.org/10.1016/0960-894x(94)00476-v
Autor:
William J. Greenlee, Terry S. Schorn, Kristie A. Faust, Peter K. S. Siegl, Salah D. Kivlighn, Tsing-Bau Chen, Stephen E. de Laszlo, Gloria J. Zingaro, Victor J. Lotti, Tomasz W. Glinka, Raymond S.L. Chang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2337-2342
The quinazoline sulfonylcarbamate L-163,579 (9) is a potent, balanced antagonist of the binding of angiotensin II (Ang II) to human AT 1 and AT 2 receptors. This antagonist produces a long-lasting blockade of Ang II-induced pressor response in both r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96faf37f446e5b44223383aee9e35010
https://doi.org/10.1016/0960-894x(94)85036-4
https://doi.org/10.1016/0960-894x(94)85036-4
Autor:
Tsing-B. Chen, Kristie A. Faust, Elizabeth M. Naylor, Bradley V. Clineschmidt, Prasun K. Chakravarty, Victor J. Lotti, Robert J. Bendesky, Stacey A. O'Malley, Paul J. Kling, Raymond S.L. Chang, Arthur A. Patchett, William J. Greenlee
Publikováno v:
Drug Development Research. 32:161-171
MK-996 (N-((4′-((5,7-Dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl) (1,1′-biphenyl)-2-yl) sulfonylbenzamide) interacted in a competitive manner with rabbit aortic angiotensin II (All) receptors as determined by Scatchard analysis of speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68303a85da0e134d25fe0d985f25b245
https://doi.org/10.1002/ddr.430320306
https://doi.org/10.1002/ddr.430320306
Autor:
William J. Greenlee, Salah D. Kivlighn, Victor J. Lotti, Terry S. Schorn, Peter K. S. Siegl, Stephen E. de Laszlo, Raymond S.L. Chang, Gloria J. Zingaro, Tomasz W. Glinka, Tsing-Bau Chen, Kristie A. Faust
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:81-86
The structure activity relationships of a series of 2-alkyl-6-(acylamino)-3-[((2′-acylaminosulfonyl)biphenyl-4-yl)methyl]quinazolin-4-(3H)-ones were studied in order to identify balanced angiotensin II antagonists capable of potent binding to both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22b08df6995c9ff8a242546b0a89ed6c
https://doi.org/10.1016/s0960-894x(01)81126-4
https://doi.org/10.1016/s0960-894x(01)81126-4
Autor:
L.W. Schaffer, Victor J. Lotti, Prasun K. Chakravarty, Wallace T. Ashton, Arthur A. Patchett, Tsing-Bau Chen, K. L. Flanagan, Salah D. Kivlighn, Elizabeth M. Naylor, W.J. Greenlee, Robert J. Bendesky, Linda L. Chang, Peter K. S. Siegl, R. S. L. Chang, Terry W. Schorn, Kristie A. Faust, Gloria J. Zingaro, Paul J. Kling
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:115-120
A series of trisubstituted triazolinones with a [2′-(N-acylsulfamoy)biphenyl-4-yl]methyl side chain at N4 has been prepared. The inhibition of AII pressor responses by these potent AT1-selective AII antagonists indicated some of them to be superior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::720a97dfb54ac5c0536c2b9ce2534228
https://doi.org/10.1016/s0960-894x(01)81132-x
https://doi.org/10.1016/s0960-894x(01)81132-x
Autor:
Gloria J. Zingaro, William J. Greenlee, Tsing-Bau Chen, Kristie A. Faust, Pancras C. Wong, Ruth R. Wexler, Victor J. Lotti, Peter K. S. Siegl, Raymond S.L. Chang, Prasun K. Chakravarty, Elizabeth M. Naylor, Salah D. Kivlighn, Colleen A. Costello, Arthur A. Patchett, David J. Carini
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:69-74
Acyl sulfonamides and acyl sulfamides were synthesized and their in vitro and in vivo biological properties evaluated. AT1 binding affinities for these potent AII antagonists were similar to their tetrazole analogs. An enhancement in AT2 potencies wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f1bd5f8936506268fac7d94f6e8eea2
https://doi.org/10.1016/s0960-894x(01)81124-0
https://doi.org/10.1016/s0960-894x(01)81124-0
Autor:
Victor J. Lotti, Wallace T. Ashton, Flanagan Kl, R. S. L. Chang, William J. Greenlee, M. Maccoss, Tsing-Bau Chen, Robert A. Strelitz, Linda L. Chang, Kristie A. Faust
Publikováno v:
Journal of Medicinal Chemistry. 36:2558-2568
A series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones was prepared via several synthetic routes and evaluated as AII receptor antagonists in vitro and in vivo. The preferred compounds contained a [2'-(5-tetrazolyl)biphenyl-4-yl]methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4587c2676c854fde8b9b1e9de11ae78
https://doi.org/10.1021/jm00069a015
https://doi.org/10.1021/jm00069a015
Autor:
William J. Greenlee, Tsing-Bau Chen, Kristie A. Faust, Stephen E. de Laszlo, Carol S. Quagliato, Victor J. Lotti, Raymond S.L. Chang, Song X. Huang, Eric E. Allen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1293-1298
We present the design, syntheses, and in vitro biological data of a series of substituted quinazolinone containing, AT1 selective, Angiotensin II (AII) receptor antagonists. Substituents at the 6-position of the quinazolin-4(3H)-ones 3 have pronounce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9fa95ce519c3e320b671e481eae2bca
https://doi.org/10.1016/s0960-894x(00)80334-0
https://doi.org/10.1016/s0960-894x(00)80334-0