Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kristie, Wood"'
Autor:
Giorgio Anselmi, Kristine Vaivode, Charles-Antoine Dutertre, Pierre Bourdely, Yoann Missolo-Koussou, Evan Newell, Oliver Hickman, Kristie Wood, Alka Saxena, Julie Helft, Florent Ginhoux, Pierre Guermonprez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Classical human dendritic cells (cDCs) are rare sentinel cells specialized in regulating adaptive immunity. Here, the authors show that expression of membrane bound FLT3L, along with stem cell factor (SCF) and CXCL12 in stromal cells induces specific
Externí odkaz:
https://doaj.org/article/063014aa8c3746a095f182dc864bceda
Autor:
Christos Tziotzios, Christos Petridis, Nick Dand, Chrysanthi Ainali, Jake R. Saklatvala, Venu Pullabhatla, Alexandros Onoufriadis, Rashida Pramanik, David Baudry, Sang Hyuck Lee, Kristie Wood, Lu Liu, Seth Seegobin, Gregory A. Michelotti, Su M. Lwin, Evangelos A. A. Christou, Charles J. Curtis, Emanuele de Rinaldis, Alka Saxena, Susan Holmes, Matthew Harries, Ioulios Palamaras, Fiona Cunningham, Gregory Parkins, Manjit Kaur, Paul Farrant, Andrew McDonagh, Andrew Messenger, Jennifer Jones, Victoria Jolliffe, Iaisha Ali, Michael Ardern-Jones, Charles Mitchell, Nigel Burrows, Ravinder Atkar, Cedric Banfield, Anton Alexandroff, Caroline Champagne, Hywel L. Cooper, Sergio Vañó-Galván, Ana Maria Molina-Ruiz, Nerea Ormaechea Perez, Girish K. Patel, Abby Macbeth, Melanie Page, Alyson Bryden, Megan Mowbray, Shyamal Wahie, Keith Armstrong, Nicola Cooke, Mark Goodfield, Irene Man, David de Berker, Giles Dunnill, Anita Takwale, Archana Rao, Tee-Wei Siah, Rodney Sinclair, Martin S. Wade, Ncoza C. Dlova, Jane Setterfield, Fiona Lewis, Kapil Bhargava, Niall Kirkpatrick, Xavier Estivill, Catherine M. Stefanato, Carsten Flohr, Timothy Spector, Fiona M. Watt, Catherine H. Smith, Jonathan N. Barker, David A. Fenton, Michael A. Simpson, John A. McGrath
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Frontal fibrosing alopecia (FFA) features lichenoid cutaneous inflammation and scarring hair loss. Here, Tziotzios et al. identify four genetic loci associated with FFA by GWAS followed by Bayesian fine-mapping, co-localisation and HLA imputation whi
Externí odkaz:
https://doaj.org/article/2a42af5d272646528b4002af71d71088
Autor:
Michael J. O'Neill, David A. Collier, Alan Hodgkinson, Richard Dobson, Guillermo Carbajosa, Eva Wozniak, Hong Wang, Nathan Lawless, Angela Hodges, Stephen Newhouse, John W. Ryder, Kristie Wood, Karim Malki, Charles A. Mein
A microglia response to pathogenic signals in diseases such as Alzheimer’s disease (AD) has long been recognised, but recent genetic findings have cemented their direct causal contribution to AD and thus the potential to target them or their effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae8f3b1fabf1d01baebb27a64970fc96
https://doi.org/10.1101/2021.07.16.452732
https://doi.org/10.1101/2021.07.16.452732
Autor:
Paul Farrant, Mark Goodfield, Catherine H. Smith, V. Jolliffe, Gregory Parkins, Caroline Champagne, Lu Liu, Nigel Burrows, A. S. Bryden, Kristie Wood, Anton B. Alexandroff, Irene Man, Alka Saxena, Su M. Lwin, Iaisha Ali, Catherine M. Stefanato, Kapil Bhargava, Sang Hyuck Lee, Melanie Page, Xavier Estivill, Tim D. Spector, Carsten Flohr, Susan Holmes, David de Berker, A. E. Macbeth, Ncoza C. Dlova, David Baudry, Jake Saklatvala, Nerea Ormaechea Perez, Archana Rao, David A. Fenton, Martin S Wade, Cedric Charles Banfield, Jennifer Jones, Evangelos A A Christou, Ravinder Atkar, Gregory A Michelotti, Sergio Vano-Galvan, Seth D. Seegobin, Jane Setterfield, Jonathan Barker, Chrysanthi Ainali, Christos Tziotzios, Charles Curtis, Rashida Pramanik, Matthew Harries, Girish K Patel, Niall Kirkpatrick, Venu Pullabhatla, Fiona Cunningham, Nick Dand, Hywel L Cooper, Rodney Sinclair, Keith Armstrong, Emanuele de Rinaldis, Andrew J. G. McDonagh, M R Kaur, Fiona Lewis, Michael A. Simpson, John A. McGrath, Charles E. Mitchell, Nicola Cooke, Fiona M. Watt, Alexandros Onoufriadis, Michael R. Ardern-Jones, Tee-Wei Siah, Ioulios Palamaras, Ana María Molina-Ruiz, Megan Mowbray, A. Takwale, Andrew G. Messenger, Giles Dunnill, Christos Petridis, Shyamal Wahie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Tziotzios, C, Petridis, C, Dand, N, Ainali, C, Saklatvala, J R, Pullabhatla, V, Onoufriadis, A, Pramanik, R, Baudry, D, Lee, S H, Wood, K, Liu, L, Seegobin, S, Michelotti, G A, Lwin, S M, Christou, E A A, Curtis, C J, de Rinaldis, E, Saxena, A, Holmes, S, Harries, M, Palamaras, I, Cunningham, F, Parkins, G, Kaur, M, Farrant, P, McDonagh, A, Messenger, A, Jones, J, Jolliffe, V, Ali, I, Ardern-Jones, M, Mitchell, C, Burrows, N, Atkar, R, Banfield, C, Alexandroff, A, Champagne, C, Cooper, H L, Vañó-Galván, S, Molina-Ruiz, A M, Perez, N O, Patel, G K, Macbeth, A, Page, M, Bryden, A, Mowbray, M, Wahie, S, Armstrong, K, Cooke, N, Goodfield, M, Man, I, de Berker, D, Dunnill, G, Takwale, A, Rao, A, Siah, T-W, Sinclair, R, Wade, M S, Dlova, N C, Setterfield, J, Lewis, F, Bhargava, K, Kirkpatrick, N, Estivill, X, Stefanato, C M, Flohr, C, Spector, T, Watt, F M, Smith, C H, Barker, J N, Fenton, D A, Simpson, M A & McGrath, J A 2019, ' Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 ', Nature Communications, vol. 10, no. 1, 1150 . https://doi.org/10.1038/s41467-019-09117-w
Tziotzios, C, Petridis, C, Dand, N, Ainali, C, Saklatvala, J R, Pullabhatla, V, Onoufriadis, A, Pramanik, R, Baudry, D, Lee, S H, Wood, K, Liu, L, Seegobin, S, Michelotti, G A, Lwin, S M, Christou, E A A, Curtis, C J, de Rinaldis, E, Saxena, A, Holmes, S, Harries, M, Palamaras, I, Cunningham, F, Parkins, G, Kaur, M, Farrant, P, McDonagh, A, Messenger, A, Jones, J, Jolliffe, V, Ali, I, Ardern-Jones, M, Mitchell, C, Burrows, N, Atkar, R, Banfield, C, Alexandroff, A, Champagne, C, Cooper, H L, Vañó-Galván, S, Molina-Ruiz, A M, Perez, N O, Patel, G K, Macbeth, A, Page, M, Bryden, A, Mowbray, M, Wahie, S, Armstrong, K, Cooke, N, Goodfield, M, Man, I, de Berker, D, Dunnill, G, Takwale, A, Rao, A, Siah, T W, Sinclair, R, Wade, M S, Dlova, N C, Setterfield, J, Lewis, F, Bhargava, K, Kirkpatrick, N, Estivill, X, Stefanato, C M, Flohr, C, Spector, T, Watt, F M, Smith, C H, Barker, J N, Fenton, D A, Simpson, M A & McGrath, J A 2019, ' Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 ', Nature Communications, vol. 10, no. 1, 1150 . https://doi.org/10.1038/s41467-019-09117-w
Nature Communications
Tziotzios, C, Petridis, C, Dand, N, Ainali, C, Saklatvala, J R, Pullabhatla, V, Onoufriadis, A, Pramanik, R, Baudry, D, Lee, S H, Wood, K, Liu, L, Seegobin, S, Michelotti, G A, Lwin, S M, Christou, E A A, Curtis, C J, de Rinaldis, E, Saxena, A, Holmes, S, Harries, M, Palamaras, I, Cunningham, F, Parkins, G, Kaur, M, Farrant, P, McDonagh, A, Messenger, A, Jones, J, Jolliffe, V, Ali, I, Ardern-Jones, M, Mitchell, C, Burrows, N, Atkar, R, Banfield, C, Alexandroff, A, Champagne, C, Cooper, H L, Vañó-Galván, S, Molina-Ruiz, A M, Perez, N O, Patel, G K, Macbeth, A, Page, M, Bryden, A, Mowbray, M, Wahie, S, Armstrong, K, Cooke, N, Goodfield, M, Man, I, de Berker, D, Dunnill, G, Takwale, A, Rao, A, Siah, T-W, Sinclair, R, Wade, M S, Dlova, N C, Setterfield, J, Lewis, F, Bhargava, K, Kirkpatrick, N, Estivill, X, Stefanato, C M, Flohr, C, Spector, T, Watt, F M, Smith, C H, Barker, J N, Fenton, D A, Simpson, M A & McGrath, J A 2019, ' Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 ', Nature Communications, vol. 10, no. 1, 1150 . https://doi.org/10.1038/s41467-019-09117-w
Tziotzios, C, Petridis, C, Dand, N, Ainali, C, Saklatvala, J R, Pullabhatla, V, Onoufriadis, A, Pramanik, R, Baudry, D, Lee, S H, Wood, K, Liu, L, Seegobin, S, Michelotti, G A, Lwin, S M, Christou, E A A, Curtis, C J, de Rinaldis, E, Saxena, A, Holmes, S, Harries, M, Palamaras, I, Cunningham, F, Parkins, G, Kaur, M, Farrant, P, McDonagh, A, Messenger, A, Jones, J, Jolliffe, V, Ali, I, Ardern-Jones, M, Mitchell, C, Burrows, N, Atkar, R, Banfield, C, Alexandroff, A, Champagne, C, Cooper, H L, Vañó-Galván, S, Molina-Ruiz, A M, Perez, N O, Patel, G K, Macbeth, A, Page, M, Bryden, A, Mowbray, M, Wahie, S, Armstrong, K, Cooke, N, Goodfield, M, Man, I, de Berker, D, Dunnill, G, Takwale, A, Rao, A, Siah, T W, Sinclair, R, Wade, M S, Dlova, N C, Setterfield, J, Lewis, F, Bhargava, K, Kirkpatrick, N, Estivill, X, Stefanato, C M, Flohr, C, Spector, T, Watt, F M, Smith, C H, Barker, J N, Fenton, D A, Simpson, M A & McGrath, J A 2019, ' Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 ', Nature Communications, vol. 10, no. 1, 1150 . https://doi.org/10.1038/s41467-019-09117-w
Frontal fibrosing alopecia (FFA) is a recently described inflammatory and scarring type of hair loss affecting almost exclusively women. Despite a dramatic recent increase in incidence the aetiopathogenesis of FFA remains unknown. We undertake genome
Autor:
Kristie Wood, Marie-Anne Suizzo
Publikováno v:
Innovation in Aging
It is unclear how ambiguous loss in dementia caregiving is impacted by conditions of the Covid-19 pandemic. Ambiguous loss describes situations in which closure is impossible and ambiguities within a family system ensue. Two situations of ambiguous l
Autor:
Kristie Wood, Kulvinder Lall, Alison M. Thomas, Malcolm Finlay, Muriel Nobles, Andrew Tinker, Charles A. Mein, Michael R. Barnes, Richard J. Schilling, Patricia B. Munroe, Claudia P. Cabrera
Publikováno v:
Physiol Genomics
Atrial fibrillation is a significant worldwide contributor to cardiovascular morbidity and mortality. Few studies have investigated the differences in gene expression between the left and right atrial appendages, leaving their characterization largel
Autor:
Pierre Guermonprez, Sofia Hidalgo, Julie Helft, Giorgio Anselmi, Eliane Piaggio, Anne Vincent-Salomon, Pierre Bourdely, Kristie Wood, Nicolás Gonzalo Núñez, Rodrigo Nalio Ramos, Yoann Missolo-Koussou, Jimena Tosselo, Wilfrid Richer, Kristine Vaivode, Alvaro Lladser, Alka Saxena
Publikováno v:
Immunity
Immunity, Elsevier, 2020, 53 (2), pp.335-352.e8. ⟨10.1016/j.immuni.2020.06.002⟩
Bourdely, P, Anselmi, G, Vaivode, K, Ramos, R N, Missolo-Koussou, Y, Hidalgo, S, Tosselo, J, Nuñez, N, Richer, W, Vincent-Salomon, A, Saxena, A, Wood, K, Lladser, A, Piaggio, E, Helft, J & Guermonprez, P 2020, ' Transcriptional and Functional Analysis of CD1c + Human Dendritic Cells Identifies a CD163+ Subset Priming CD8 + CD103 + T Cells ', Immunity, vol. 53, no. 2, pp. 335-352.e8 . https://doi.org/10.1016/j.immuni.2020.06.002
Immunity, Elsevier, 2020, 53, pp.335-352.e8. ⟨10.1016/j.immuni.2020.06.002⟩
Immunity, Elsevier, 2020, 53 (2), pp.335-352.e8. ⟨10.1016/j.immuni.2020.06.002⟩
Bourdely, P, Anselmi, G, Vaivode, K, Ramos, R N, Missolo-Koussou, Y, Hidalgo, S, Tosselo, J, Nuñez, N, Richer, W, Vincent-Salomon, A, Saxena, A, Wood, K, Lladser, A, Piaggio, E, Helft, J & Guermonprez, P 2020, ' Transcriptional and Functional Analysis of CD1c + Human Dendritic Cells Identifies a CD163+ Subset Priming CD8 + CD103 + T Cells ', Immunity, vol. 53, no. 2, pp. 335-352.e8 . https://doi.org/10.1016/j.immuni.2020.06.002
Immunity, Elsevier, 2020, 53, pp.335-352.e8. ⟨10.1016/j.immuni.2020.06.002⟩
Summary Dendritic cells (DCs) are antigen-presenting cells controlling T cell activation. In humans, the diversity, ontogeny, and functional capabilities of DC subsets are not fully understood. Here, we identified circulating CD88−CD1c+CD163+ DCs (
Autor:
Pierre Bourdely, Kristine Vaivode, Giorgio Anselmi, Rodrigo Nalio Ramos, Yoann Missolo-Koussou, Sofia Hidalgo, Jimena Tosselo, Nicolas Nuñez, Wilfrid Richer, Anne Vincent-Salomon, Alka Saxena, Kristie Wood, Alvaro Lladser, Eliane Piaggio, Julie Helft, Pierre Guermonprez
Publikováno v:
SSRN Electronic Journal.
Autor:
Pierre Bourdely, Pierre Guermonprez, Alka Saxena, Giorgio Anselmi, Julie Helft, Kristie Wood, Florent Ginhoux, Kristine Vaivode, Oliver Hickman, Yoann Missolo-Koussou, Charles-Antoine Dutertre, Evan W. Newell
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2054. ⟨10.1038/s41467-020-15937-y⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-15937-y⟩
Nature Communications, 2020, 11 (1), pp.2054. ⟨10.1038/s41467-020-15937-y⟩
Anselmi, G, Vaivode, K, Dutertre, C A, Bourdely, P, Missolo-Koussou, Y, Newell, E, Hickman, O, Wood, K, Saxena, A, Helft, J, Ginhoux, F & Guermonprez, P 2020, ' Engineered niches support the development of human dendritic cells in humanized mice ', Nature Communications, vol. 11, 2054 . https://doi.org/10.1038/s41467-020-15937-y
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2054. ⟨10.1038/s41467-020-15937-y⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-15937-y⟩
Nature Communications, 2020, 11 (1), pp.2054. ⟨10.1038/s41467-020-15937-y⟩
Anselmi, G, Vaivode, K, Dutertre, C A, Bourdely, P, Missolo-Koussou, Y, Newell, E, Hickman, O, Wood, K, Saxena, A, Helft, J, Ginhoux, F & Guermonprez, P 2020, ' Engineered niches support the development of human dendritic cells in humanized mice ', Nature Communications, vol. 11, 2054 . https://doi.org/10.1038/s41467-020-15937-y
Classical dendritic cells (cDCs) are rare sentinel cells specialized in the regulation of adaptive immunity. Modeling cDC development is crucial to study cDCs and harness their therapeutic potential. Here we address whether cDCs could differentiate i
Autor:
Guillermo Carbajosa, Nathan Lawless, Eva Wozniak, Karim Malki, Angela Hodges, Richard Dobson, Kristie Wood, Stephen Newhouse, Hong Wang, John W. Ryder, Michael J. O'Neill, David A. Collier, Charles A. Mein
Publikováno v:
Carbajosa, G, Malki, K, Lawless, N, Wang, H, Ryder, J W, Wozniak, E, Wood, K, Mein, C A, Dobson, R J B, Collier, D A, O'Neill, M J, Hodges, A K & Newhouse, S J 2018, ' Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain ', Neurobiology of Aging, vol. 69, pp. 151-166 . https://doi.org/10.1016/j.neurobiolaging.2018.04.019
Rare heterozygous coding variants in the Triggering Receptor Expressed in Myeloid cells 2 (TREM2) gene, conferring increased risk of developing late-onset Alzheimer's disease, have been identified. We examined the transcriptional consequences of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ee80debee5a3d95c02ee277c9de126
https://kclpure.kcl.ac.uk/ws/files/101828997/Loss_of_Trem2_in_Carbajosa_2018_GOLD_VoR.pdf
https://kclpure.kcl.ac.uk/ws/files/101828997/Loss_of_Trem2_in_Carbajosa_2018_GOLD_VoR.pdf