Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kristie, Darrah"'
Autor:
Kristie Darrah, Alexander Deiters
Publikováno v:
ACS Central Science, Vol 7, Iss 1, Pp 11-13 (2020)
Externí odkaz:
https://doaj.org/article/0b4b91d5888f4ed58d123cd2b80f1d4e
Publikováno v:
Journal of the American Chemical Society. 144:16819-16826
MicroRNAs play crucial and dynamic roles in vertebrate development and diseases. Some, like miR-430, are highly expressed during early embryo development and regulate hundreds of transcripts, which can make it difficult to study their role in the tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b6b5a244e66e206ad28b4f851460c7
https://doi.org/10.1021/jacs.2c04479
https://doi.org/10.1021/jacs.2c04479
Autor:
Rohit, Prakash, Yashpal, Rawal, Meghan R, Sullivan, McKenzie K, Grundy, Hélène, Bret, Michael J, Mihalevic, Hayley L, Rein, Jared M, Baird, Kristie, Darrah, Fang, Zhang, Raymond, Wang, Tiffany A, Traina, Marc R, Radke, Scott H, Kaufmann, Elizabeth M, Swisher, Raphaël, Guérois, Mauro, Modesti, Patrick, Sung, Maria, Jasin, Kara A, Bernstein
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(38)
Mutations in homologous recombination (HR) genes, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8433367abc41045a4885b006fd0d02b
https://pubmed.ncbi.nlm.nih.gov/36099300
https://pubmed.ncbi.nlm.nih.gov/36099300
Publikováno v:
ACS Chemical Biology. 16:2434-2443
Rapamycin-induced dimerization of FKBP and FRB is the most commonly utilized chemically induced protein dimerization system. It has been extensively used to conditionally control protein localization, split-enzyme activity, and protein-protein intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1438b466a40e92aaaca9ed6d454cd0
https://doi.org/10.1021/acschembio.1c00547
https://doi.org/10.1021/acschembio.1c00547
Autor:
Kristie Darrah, Alexander Deiters
Publikováno v:
Chem Soc Rev
Translation of mRNA into protein is one of the most fundamental processes within biological systems. Gene expression is tightly regulated both in space and time, often involving complex signaling or gene regulatory networks, as most prominently obser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ac79c27f7644c3891b83187961d0ac
https://pubmed.ncbi.nlm.nih.gov/34739027
https://pubmed.ncbi.nlm.nih.gov/34739027
Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction
Autor:
Alexander Deiters, Joshua S. Wesalo, Bradley Lukasak, Kristie Darrah, James K. Chen, Michael Tsang
Publikováno v:
J Am Chem Soc
Conditionally activated, caged morpholino antisense agents (cMOs) are tools that enable the temporal and spatial investigation of gene expression, regulation, and function during embryonic development. Cyclic MOs are conformationally gated oligonucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc631c0deb08044174aa4156949c8c9
https://europepmc.org/articles/PMC9014490/
https://europepmc.org/articles/PMC9014490/
Publikováno v:
Journal of Biological Chemistry. 294:2293-2301
Catecholamine neurotransmitter levels in the synapses of the brain shape human disposition—cognitive flexibility, aggression, depression, and reward seeking—and manipulating these levels is a major objective of the pharmaceutical industry. Certai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c91529634fada0e899d30f27fad4c62
https://doi.org/10.1074/jbc.ra118.006511
https://doi.org/10.1074/jbc.ra118.006511
Publikováno v:
The Journal of Biological Chemistry
Controlling unmodified serotonin levels in brain synapses is a primary objective when treating major depressive disorder - a disease that afflicts ~20% of the world's population. Roughly 60% of patients respond poorly to first-line treatments and thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cad720d003b48d451231b4b31986a0c
http://europepmc.org/articles/PMC7948405
http://europepmc.org/articles/PMC7948405
Publikováno v:
J Am Chem Soc
As an emerging approach to protein perturbation, small molecule-induced protein degradation has gained significant attention as both a chemical tool and a potential therapeutic. To enable discrete control over its function, we have developed a broadl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aadbb483df54bb46f09af5aa3614dc12
https://doi.org/10.26434/chemrxiv.8216714.v1
https://doi.org/10.26434/chemrxiv.8216714.v1